Experimental Verification of Electromagnetic Simulations of a HIFI Mixer Sub-Assembly

Phase II of the study "Far-Infrared Optics Design & Verification", commissioned by the European Space Agency (ESA), we investigate the ability of several commercial software packages (GRASP, CODEV, GLAD and ASAP) to predict the performance of a representative example of a submillimeter-wave optical system. In this paper, we use the software packages to predict the behaviour of a Mixer Sub-Assembly (MSA) of HIFI, and we compare the simulations with near-field measurements at 480 GHz. In order to be able to distinguish between the predictions of the packages, we move the corrugated horn of the MSA through its nominal focus position. A unique feature of the experimental arrangement is that the measured position of every field point is known absolutely to within fractions of a wavelength. In this paper we present the results of this through-focus experiment, which give a good first-order indication of the agreement between measured and simulated behaviour of a typical submillimeter-wave optical system

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival

MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells of the sympathetic nervous system. We have analyzed a set of neuroblastoma (n = 145) that is broadly representative of the genetic subtypes of this disease for miRNA expression (430 loci by stem-loop RT qPCR) and for DNA copy number alterations (array CGH) to assess miRNA involvement in disease pathogenesis. The tumors were stratified and then randomly split into a training set (n = 96) and a validation set (n = 49) for data analysis. Thirty-seven miRNAs were significantly over-or under-expressed in MYCN amplified tumors relative to MYCN single copy tumors, indicating a potential role for the MYCN transcription factor in either the direct or indirect dysregulation of these loci. In addition, we also determined that there was a highly significant correlation between miRNA expression levels and DNA copy number, indicating a role for large-scale genomic imbalances in the dysregulation of miRNA expression. In order to directly assess whether miRNA expression was predictive of clinical outcome, we used the Random Forest classifier to identify miRNAs that were most significantly associated with poor overall patient survival and developed a 15 miRNA signature that was predictive of overall survival with 72.7% sensitivity and 86.5% specificity in the validation set of tumors. We conclude that there is widespread dysregulation of miRNA expression in neuroblastoma tumors caused by both over-expression of the MYCN transcription factor and by large-scale chromosomal imbalances. MiRNA expression patterns are also predicative of clinical outcome, highlighting the potential for miRNA mediated diagnostics and therapeutics

Creating a community of praxis: integrating global citizenship and development education across campus at University College Cork

The Praxis Project, established at University College Cork (UCC), Ireland, in 2018, seeks to assess possible models of best practice with regard to the integration of global citizenship and development education (GCDE) into a cross-disciplinary, cross-campus, interwoven set of subject area pedagogies, policies and practices. This study – the first part of an eventual three-part framework – asserts that the themes, theories, values, skills, approaches and methodologies relevant to transformative pedagogical work are best underpinned by ongoing staff dialogue in order to build communities of support around such systemic pedagogical change. This article is based on a collaborative study with the first cohort of UCC staff (2020–1), which demonstrates many ways in which staff and students realised that smaller actions and carefully directed attention to specific issues opened doors to transformative thinking and action in surprising ways. From this viewpoint, the striking need emerged for taking a strategic approach to how GCDE is, and should be, integrated into learning across subject areas

Characterization of the Millimeter-Wave Polarization of Centaurus A with QUaD

Centaurus (Cen) A represents one of the best candidates for an isolated, compact, highly polarized source that is bright at typical cosmic microwave background (CMB) experiment frequencies. We present measurements of the 4 degree by 2 degree region centered on Cen A with QUaD, a CMB polarimeter whose absolute polarization angle is known to 0.5 degrees. Simulations are performed to assess the effect of misestimation of the instrumental parameters on the final measurement and systematic errors due to the field's background structure and temporal variability from Cen A's nuclear region are determined. The total (Q, U) of the inner lobe region is (1.00 +/- 0.07 (stat.) +/- 0.04 (sys.), -1.72 +/- 0.06 +/- 0.05) Jy at 100 GHz and (0.80 +/- 0.06 +/- 0.06, -1.40 +/- 0.07 +/- 0.08) Jy at 150 GHz, leading to polarization angles and total errors of -30.0 +/- 1.1 degrees and -29.1 +/- 1.7 degrees. These measurements will allow the use of Cen A as a polarized calibration source for future millimeter experiments.Comment: 9 pages, 8 figures, v2 matches version published in Ap

Neutral organic super electron donors made catalytic

Neutral organic super electron donors (SEDs) display impressive reducing power but, until now, it has not been possible to use them catalytically in radical chain reactions. This is because, following electron transfer, these donors form persistent radical cations that trap substrate-derived radicals. This paper unlocks a conceptually new approach to super electron donors that overcomes this issue, leading to the first catalytic neutral organic super electron donor

First season QUaD CMB temperature and polarization power spectra

QUaD is a bolometric CMB polarimeter sited at the South Pole, operating at frequencies of 100 and 150 GHz. In this paper we report preliminary results from the first season of operation (austral winter 2005). All six CMB power spectra are presented derived as cross spectra between the 100 and 150 GHz maps using 67 days of observation in a low foreground region of approximately 60 deg^2. These data are a small fraction of the data acquired to date. The measured spectra are consistent with the ΛCDM cosmological model. We perform jackknife tests that indicate that the observed signal has negligible contamination from instrumental systematics. In addition, by using a frequency jackknife we find no evidence for foreground contamination

Scientific optimization of a ground-based CMB polarization experiment

We investigate the science goals achievable with the upcoming generation of ground-based Cosmic Microwave Background polarization experiments and calculate the optimal sky coverage for such an experiment including the effects of foregrounds. We find that with current technology an E-mode measurement will be sample-limited, while a B-mode measurement will be detector-noise-limited. We conclude that a 300 sq deg survey is an optimal compromise for a two-year experiment to measure both E and B-modes, and that ground-based polarization experiments can make an important contribution to B-mode surveys. Focusing on one particular experiment, QUaD, a proposed bolometric polarimeter operating from the South Pole, we find that a ground-based experiment can make a high significance measurement of the acoustic peaks in the E-mode spectrum, and will be able to detect the gravitational lensing signal in the B-mode spectrum. Such an experiment could also directly detect the gravitational wave component of the B-mode spectrum if the amplitude of the signal is close to current upper limits. We also investigate how a ground-based experiment can improve constraints on the cosmological parameters. We estimate that by combining two years of QUaD data with the four-year WMAP data, an optimized ground-based polarization experiment can improve constraints on cosmological parameters by a factor of two. If the foreground contamination can be reduced, the measurement of the tensor-to-scalar ratio can be improved by up to a factor of six over that obtainable from WMAP alone.Comment: 17 pages, 11 figures replaced with version accepted by MNRA

Variable Glycemic Responses to Intact and Hydrolyzed Milk Proteins in Overweight and Obese Adults Reveal the Need for Precision Nutrition

peer-reviewedBackground Dietary modifications can contribute to improved pancreatic β cell function and enhance glycemic control. Objectives The objectives of this study were as follows: 1) to investigate the potential of milk protein hydrolysates to modulate postprandial glucose response; 2) to assess individual responses; and 3) to explore the inter- and intraindividual reproducibility of the response. Methods A 14-d randomized crossover study investigated interstitial glucose levels of participants in response to 12% w/v milk protein drinks (intact caseinate and casein hydrolysate A and B) consumed in random order with a 2-d washout between treatments. Milk protein drinks were consumed immediately prior to study breakfast and evening meals. Twenty participants (11 men, 9 women) aged 50 ± 8 y with a body mass index (in kg/m2) of 30.2 ± 3.1 were recruited. Primary outcome was glucose levels assessed at 15-min intervals with the use of glucose monitors. Results Repeated-measures ANOVA revealed that for breakfast there was a significant difference across the 3 treatment groups (P = 0.037). The ability to reduce postprandial glucose was specific to casein hydrolysate B in comparison with intact caseinate (P = 0.039). However, despite this significant difference, further examination revealed that only 3 out of 18 individuals were classified as responders (P < 0.05). High intraclass correlation coefficients were obtained for glucose response to study meals (intraclass correlation coefficient: 0.892 for breakfast with intact caseinate). The interindividual CVs were higher than the intraindividual CVs. Mean inter- and intraindividual CVs were 19.4% and 5.7%, respectively, for breakfast with intact caseinate. Conclusion Ingestion of a specific casein hydrolysate successfully reduced the postprandial glucose response; however, at an individual level only 3 participants were classified as responders, highlighting the need for precision nutrition. Exploration of high interindividual responses to nutrition interventions is needed, in combination with the development of precision nutrition, potentially through an n-of-1 approach. This clinical trial was registered as ISRCTN61079365 (https://www.isrctn.com/).Food for Health Irelan

A pilot study demonstrating the altered gut microbiota functionality in stable adults with Cystic Fibrosis

peer-reviewedCystic Fibrosis (CF) and its treatment result in an altered gut microbiota composition compared to non-CF controls. However, the impact of this on gut microbiota functionality has not been extensively characterised. Our aim was to conduct a proof-of-principle study to investigate if measurable changes in gut microbiota functionality occur in adult CF patients compared to controls. Metagenomic DNA was extracted from faecal samples from six CF patients and six non-CF controls and shotgun metagenomic sequencing was performed on the MiSeq platform. Metabolomic analysis using gas chromatography-mass spectrometry was conducted on faecal water. The gut microbiota of the CF group was significantly different compared to the non-CF controls, with significantly increased Firmicutes and decreased Bacteroidetes. Functionality was altered, with higher pathway abundances and gene families involved in lipid (e.g. PWY 6284 unsaturated fatty acid biosynthesis (p = 0.016)) and xenobiotic metabolism (e.g. PWY-5430 meta-cleavage pathway of aromatic compounds (p = 0.004)) in CF patients compared to the controls. Significant differences in metabolites occurred between the two groups. This proof-of-principle study demonstrates that measurable changes in gut microbiota functionality occur in CF patients compared to controls. Larger studies are thus needed to interrogate this further

Multimode horn antennas for far-infrared astronomy

Multi-mode horns combined with bolometric or incoherent detectors are finding application in astronomical receivers for which partially coherent operation can provide increased throughput and thus sensitivity. This is advantageous when observing faint sources, especially if diffraction limited resolution is not required, or if the horn beam is truncated by a cold stop in the optical train. We discuss how such horns can be simulated and present examples from receiver instrumentation on the Planck and SPICA space telescopes