The patient perspective in research on major depression

Although thousands of studies have examined the genetics, epidemiology, etiology, biology, treatment and prevention of major depressive disorder, we still lack very basic knowledge about what patients with depressive disorders need. Despite the thousands of studies that have been conducted on major depression and the hundreds of randomized trials that have examined the effects of treatments, many patients still do not know how to cope with the daily problems caused by depressive disorders. In this Commentary the need for more research on the perspectives of patients is described. This research should guide treatment studies as well as basic research much more than it currently does. This perpective is especially important to understand and solve the undertreatment of depression, one of the major problems in this area. Up to 50% of depressed patients do not seek treatment, resulting in huge avoidable disease burden and economic costs. In order to solve this problem we need a better understanding of the problems patients encounter in daily life, and what factors contribute to the reasons for seeking treatment or not. Research from the patients' perspective is also necessary to meet the currently unmet information needs of patients, including information about the nature and causes of depression, stigma, medication, treatment and coping with the daily problems of having depression

Greenhouse gas emissions resulting from conversion of peat swamp forest to oil palm plantation.

Conversion of tropical peat swamp forest to drainage-based agriculture alters greenhouse gas (GHG) production, but the magnitude of these changes remains highly uncertain. Current emissions factors for oil palm grown on drained peat do not account for temporal variation over the plantation cycle and only consider CO2 emissions. Here, we present direct measurements of GHGs emitted during the conversion from peat swamp forest to oil palm plantation, accounting for CH4 and N2O as well as CO2. Our results demonstrate that emissions factors for converted peat swamp forest is in the range 70-117 t CO2 eq ha-1 yr-1 (95% confidence interval, CI), with CO2 and N2O responsible for ca. 60 and ca. 40% of this value, respectively. These GHG emissions suggest that conversion of Southeast Asian peat swamp forest is contributing between 16.6 and 27.9% (95% CI) of combined total national GHG emissions from Malaysia and Indonesia or 0.44 and 0.74% (95% CI) of annual global emissions

On-site genetic analysis for species identification using lab-on-a-chip

© 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd This paper presents a microfluidic device capable of performing genetic analysis on dung samples to identify White Rhinoceros (Ceratotherium simum). The development of a microfluidic device, which can be used in the field, offers a portable and cost-effective solution for DNA analysis and species identification to aid conservation efforts. Optimization of the DNA extraction processes produced equivalent yields compared to conventional kit-based methods within just 5 minutes. The use of a color-changing loop-mediated isothermal amplification reaction for simultaneous detection of the cytochrome B sequence of C. simum enabled positive results to be obtained within as little as 30 minutes. Field testing was performed at Knowsley Safari to demonstrate real-world applicability of the microfluidic device for testing of biological samples

Circulation in the vicinity of Mackenzie Canyon from a year-long mooring array

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Lin, P., Pickart, R. S., Fissel, D., Ross, E., Kasper, J., Bahr, F., Torres, D. J., O'Brien, J., Borg, K., Melling, H., & Wiese, F. K. Circulation in the vicinity of Mackenzie Canyon from a year-long mooring array. Progress in Oceanography, 187, (2020): 102396, doi:10.1016/j.pocean.2020.102396.Data from a five-mooring array extending from the inner shelf to the continental slope in the vicinity of Mackenzie Canyon, Beaufort Sea are analyzed to elucidate the components of the boundary current system and their variability. The array, part of the Marine Arctic Ecosystem Study (MARES), was deployed from October 2016 to September 2017. Four distinct currents were identified: an eastward-directed flow adjacent to the coast; a westward-flowing, surface-intensified current centered on the outer-shelf; a bottom-intensified shelfbreak jet flowing to the east; and a recirculation at the base of the continental slope within the canyon. The shelf current transports −0.120.03 Sv in the mean and is primarily wind-driven. The response is modulated by the presence of ice, with little-to-no signal during periods of nearly-immobile ice cover and maximum response when there is partial ice cover. The shelfbreak jet transports 0.030.02 Sv in the mean, compared to 0.080.02 Sv measured upstream in the Alaskan Beaufort Sea over the same time period. The loss of transport is consistent with a previous energetics analysis and the lack of Pacific-origin summer water downstream. The recirculation in the canyon appears to be the result of local dynamics whereby a portion of the westward-flowing southern limb of the Beaufort Gyre is diverted up the canyon across isobaths. This interpretation is supported by the fact that the low-frequency variability of the recirculation is correlated with the wind-stress curl in the Canada Basin, which drives the Beaufort gyre.The authors are indebted to Fisheries and Oceans Canada for building the logistics for MARES into the at-sea missions of the Integrated Beaufort Observatory. We are grateful to the captain and crew of the CCGS Sir Wilfred Laurier for ably deploying and recovering the MARES array. Marshall Swartz assisted with the cruise preparation logistics. We thank the two anonymous reviewers for their input which helped improve the paper. This project was funded by the US Bureau of Ocean Energy Management (BOEM), on behalf of the National Ocean Partnership Program. The Canadian contribution was supported by the Environmental Studies Research Fund (ESRF Project 2014-02N). MARES publication 003