The Quantum Socket: Three-Dimensional Wiring for Extensible Quantum Computing

Quantum computing architectures are on the verge of scalability, a key requirement for the implementation of a universal quantum computer. The next stage in this quest is the realization of quantum error correction codes, which will mitigate the impact of faulty quantum information on a quantum computer. Architectures with ten or more quantum bits (qubits) have been realized using trapped ions and superconducting circuits. While these implementations are potentially scalable, true scalability will require systems engineering to combine quantum and classical hardware. One technology demanding imminent efforts is the realization of a suitable wiring method for the control and measurement of a large number of qubits. In this work, we introduce an interconnect solution for solid-state qubits: The quantum socket. The quantum socket fully exploits the third dimension to connect classical electronics to qubits with higher density and better performance than two-dimensional methods based on wire bonding. The quantum socket is based on spring-mounted micro wires the three-dimensional wires that push directly on a micro-fabricated chip, making electrical contact. A small wire cross section (~1 mmm), nearly non-magnetic components, and functionality at low temperatures make the quantum socket ideal to operate solid-state qubits. The wires have a coaxial geometry and operate over a frequency range from DC to 8 GHz, with a contact resistance of ~150 mohm, an impedance mismatch of ~10 ohm, and minimal crosstalk. As a proof of principle, we fabricated and used a quantum socket to measure superconducting resonators at a temperature of ~10 mK.Comment: Main: 31 pages, 19 figs., 8 tables, 8 apps.; suppl.: 4 pages, 5 figs. (HiRes figs. and movies on request). Submitte

What next for Shared Lives? Family-based support as a potential option for older people

With an ageing population and limited resources the challenge for policy makers and practitioners is how best to provide for the care and support needs of older people. This article draws on findings from two studies, a scoping study of the personalisation of care services and another which aimed to generate evidence about the potential use of family-based support schemes (Shared Lives, SL) for certain groups of older people. Forty-three schemes participated in a survey to gather information about services provided and the extent to which this included older people and their carers, and six staffs were interviewed across two schemes about issues for expanding provision for older people in their local areas. It was evident that SL schemes were already supporting a number of older people and there was support for expansion from both schemes and local authorities. Adequate resources, awareness raising, management commitment, and a pool of suitable carers would be needed to support any expansion effort. There is also still a need for SL to be more widely known and understood by care managers if it is to be considered part of mainstream provision for older people

Prevalence and risk of Down syndrome in monozygotic and dizygotic multiple pregnancies in Europe: implications for prenatal screening.

OBJECTIVE: To determine risk of Down syndrome (DS) in multiple relative to singleton pregnancies, and compare prenatal diagnosis rates and pregnancy outcome. DESIGN: Population-based prevalence study based on EUROCAT congenital anomaly registries. SETTING: Eight European countries. POPULATION: 14.8 million births 1990-2009; 2.89% multiple births. METHODS: DS cases included livebirths, fetal deaths from 20 weeks, and terminations of pregnancy for fetal anomaly (TOPFA). Zygosity is inferred from like/unlike sex for birth denominators, and from concordance for DS cases. MAIN OUTCOME MEASURES: Relative risk (RR) of DS per fetus/baby from multiple versus singleton pregnancies and per pregnancy in monozygotic/dizygotic versus singleton pregnancies. Proportion of prenatally diagnosed and pregnancy outcome. STATISTICAL ANALYSIS: Poisson and logistic regression stratified for maternal age, country and time. RESULTS: Overall, the adjusted (adj) RR of DS for fetus/babies from multiple versus singleton pregnancies was 0.58 (95% CI 0.53-0.62), similar for all maternal ages except for mothers over 44, for whom it was considerably lower. In 8.7% of twin pairs affected by DS, both co-twins were diagnosed with the condition. The adjRR of DS for monozygotic versus singleton pregnancies was 0.34 (95% CI 0.25-0.44) and for dizygotic versus singleton pregnancies 1.34 (95% CI 1.23-1.46). DS fetuses from multiple births were less likely to be prenatally diagnosed than singletons (adjOR 0.62 [95% CI 0.50-0.78]) and following diagnosis less likely to be TOPFA (adjOR 0.40 [95% CI 0.27-0.59]). CONCLUSIONS: The risk of DS per fetus/baby is lower in multiple than singleton pregnancies. These estimates can be used for genetic counselling and prenatal screening

Knowledge-based energy functions for computational studies of proteins

This chapter discusses theoretical framework and methods for developing knowledge-based potential functions essential for protein structure prediction, protein-protein interaction, and protein sequence design. We discuss in some details about the Miyazawa-Jernigan contact statistical potential, distance-dependent statistical potentials, as well as geometric statistical potentials. We also describe a geometric model for developing both linear and non-linear potential functions by optimization. Applications of knowledge-based potential functions in protein-decoy discrimination, in protein-protein interactions, and in protein design are then described. Several issues of knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

Canola yield formation under different population and water use levels

Non-Peer ReviewedOptimum population is the foundation for high yields under rain-fed agriculture and the optimum population depends on the water availability. However, establishing a good canola stand in the Canadian semiarid Prairie, where low temperature, water stress and soil crusting result in poor seed bed conditions, is difficult. A field study was conducted during 2000, a year with moderate soil moisture and good canola growing conditions, and 2001, a year with severe water and heat stress, to understand the plasticity of canola yield parameters at different (80 to 5 plants per square meter) plant populations. The primary response of canola to lower plant population was increased branching, although it did not compensate completely for the decreasing population. Increased branching was accompanied by increased production and increased distribution of pods on the primary and secondary branches. Canola exhibited plasticity in yield adjustment over a wide range of plant populations. Environmental conditions played a significant role in expressing canola plasticity. For example, in a normal year like 2000 canola maintained similar yield levels over a wider range of populations (80 to 20 pl m-2), while in a dry year like 2001 seed yield started declining with populations below 40 pl m-2. Ability to produce more pods, especially at lower population densities, was responsible for the environmental influence on yield formation

Stubble height and fertilizer N requirements for maximizing canola yield in the semiarid Canadian prairie

Non-Peer ReviewedCanola is becoming a viable crop when grown under fallow in the semiarid prairie, but is also grown in longer rotations, most often direct seeded into standing stubble. Taller standing stubble provides the canola seedlings with a more favorable micro-climate promoting more efficient use of water and increased yields compared to canola grown without the protection of standing stubble. When grown under the more limited moisture conditions of extended rotations but in the moisture conserving characteristics of taller standing stubble, we found canola yielded best with fertilizer N rates similar to those of the moister Black soil zone. Canola yields were consistently highest when fertilized with > 100 kg N ha-1

Analyzing color infrared aerial photographs for the delineation of management units in site-specific agricultural management

Non-Peer ReviewedThis poster addresses the potential of a color infrared aerial photograph to provide spatially distributed information for site specific management. In this process digitized color infrared aerial photographs were used to extract vegetation index information. Crop and soil information were obtained through field sampling. Most important factors for affecting crop productivity were determined using principal component analysis. Point information were interpolated using kriging to create grid surface of the study area. Centroid of each grid cell was used to collect crop and soil information, and vegetation index at a regular interval throughout the study area. Fuzzy k-means with extra-grades algorithms were used to delineate potential within-field management units based on soil and crop information and vegetation index separately. Within-zone grain yield variation were calculated and used to evaluate management zones. The methodology is fast, can be easily automated in commercially available GIS software and has considerable advantages when comparing to other methods for delineating within-field management zones