1,423 research outputs found
High-Speed Flow and Fuel Imaging Study of Available Spark Energy in a Spray-Guided Direct-Injection Engine and Implications on Misfires
The spark energy transferred under the highly stratified conditions during late injection in a spray-guided spark-ignition direct-injection (SG-SIDI) engine is not well characterized. The impact of high pressures, temperatures, velocities, and variations in local fuel concentration along with temporal and/or spatial variations on spark performance must be better characterized. Previous spark ignition studies have not addressed the full range of conditions that are present in SG-SIDI engines. Therefore, high-speed particle image velocimetry (PIV) experiments are conducted to characterize the spark energy dependence for a wide range of well-defined homogeneous fuel–air equivalence ratios (W50–2.9) and average air velocities (0–8m/s) in an optical SG-SIDI engine. Amoderate dependence of spark energy on equivalence ratio is shown to exist with average values of spark energy increasing by 21 per cent for the equivalence ratio range of W50–2.3. Air injection into the motored engine is used to prepare well-defined flow conditions without the complications of fuel concentration gradients that are present during fuel injection. This allows the study of the effects of velocity, shear strain rate, and vorticity on spark energy. The spark energy increases with velocity at the spark plug. This observation is consistent with findings reported in the literature for low-pressure conditions. A linear increase is shown between shear strain rate and spark energy, while vorticity and spark energy are only weakly correlated. Simultaneous high-speed PIV, planar laser-induced fluorescence, and spark-discharge electrical measurements are also performed in the optical SG-SIDI engine to measure flow properties and fuel concentrations under late injection. Operating parameters are chosen to be near peak indicated mean effective pressure performance, but they occasionally provide a random misfired or partial burned cycle. Misfired cycles occur under stoichiometric-to-lean mixtures and low velocities near the spark plug. The lower spark energies observed under these conditions are in agreement with the observationsmade under well-controlled mixture and flow conditions reported in this study. All mixture conditions found in misfiring and partially burning cycles are within the ignitability range and fall within the general population of all, predominantly well-burning, cycles. There is no predominant impact of shear strain rate and vorticity under late injection operation on misfires and partial burns.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86771/1/Sick7.pd
Sequence Determinants of a Specific Inactive Protein Kinase Conformation
SummaryOnly a small percentage of protein kinases have been shown to adopt a distinct inactive ATP-binding site conformation, called the Asp-Phe-Gly-out (DFG-out) conformation. Given the high degree of homology within this enzyme family, we sought to understand the basis of this disparity on a sequence level. We identified two residue positions that sensitize mitogen-activated protein kinases (MAPKs) to inhibitors that stabilize the DFG-out inactive conformation. After characterizing the structure and dynamics of an inhibitor-sensitive MAPK mutant, we demonstrated the generality of this strategy by sensitizing a kinase (apoptosis signal-regulating kinase 1) not in the MAPK family to several DFG-out stabilizing ligands, using the same residue positions. The use of specific inactive conformations may aid the study of noncatalytic roles of protein kinases, such as binding partner interactions and scaffolding effects
Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets
T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune response. The killing apparatus can also oscillate next to the cell-cell interface. When two target cells are engaged by the T cell simultaneously, the killing apparatus can oscillate between the two interface areas. This oscillation is one of the most striking examples of cell movements that give the microscopist an unmechanistic impression of the cell's fidgety indecision. We have constructed a three-dimensional, numerical biomechanical model of the molecular-motor-driven microtubule cytoskeleton that positions the killing apparatus. The model demonstrates that the cortical pulling mechanism is indeed capable of orienting the killing apparatus into the functional position under a range of conditions. The model also predicts experimentally testable limitations of this commonly hypothesized mechanism of T-cell polarization. After the reorientation, the numerical solution exhibits complex, multidirectional, multiperiodic, and sustained oscillations in the absence of any external guidance or stochasticity. These computational results demonstrate that the strikingly animate wandering of aim in T-killer cells has a purely mechanical and deterministic explanation. © 2009 Kim, Maly
Local Government Fiscal Burden in Nonmetropolitan America
Rising fiscal pressure on local governments in rural areas of the United States is documented in this study. The level of fiscal burden on taxpayers to support local governments in nonmetropolitan areas is found to be higher than that in metropolitan areas between 1977 and 1987. Using a model from the urban fiscal literature, the level of fiscal burden in nonmetropolitan areas is found to be influenced by a combination of demographic, socioeconomic, intergovernmental, and historical factors. Intergovernmental revenue transfers from the state and federal government play a critical role in determining the level of fiscal burden rural taxpayers bear. These findings have implications for rural economic development and for understanding how rural areas are influenced by the larger society
The pseudogap state in superconductors: Extended Hartree approach to time-dependent Ginzburg-Landau Theory
It is well known that conventional pairing fluctuation theory at the Hartree
level leads to a normal state pseudogap in the fermionic spectrum. Our goal is
to extend this Hartree approximated scheme to arrive at a generalized mean
field theory of pseudogapped superconductors for all temperatures . While an
equivalent approach to the pseudogap has been derived elsewhere using a more
formal Green's function decoupling scheme, in this paper we re-interpret this
mean field theory and BCS theory as well, and demonstrate how they naturally
relate to ideal Bose gas condensation. Here we recast the Hartree approximated
Ginzburg-Landau self consistent equations in a T-matrix form. This recasting
makes it possible to consider arbitrarily strong attractive coupling, where
bosonic degrees of freedom appear at considerably above . The
implications for transport both above and below are discussed. Below
we find two types of contributions. Those associated with fermionic
excitations have the usual BCS functional form. That they depend on the
magnitude of the excitation gap, nevertheless, leads to rather atypical
transport properties in the strong coupling limit, where this gap (as distinct
from the order parameter) is virtually -independent. In addition, there are
bosonic terms arising from non-condensed pairs whose transport properties are
shown here to be reasonably well described by an effective time-dependent
Ginzburg-Landau theory.Comment: 14 pages, 5 figures, REVTeX4, submitted to PRB; clarification of the
diagrammatic technique added, one figure update
Pseudogap effects induced by resonant pair scattering
We demonstrate how resonant pair scattering of correlated electrons above T_c
can give rise to pseudogap behavior. This resonance in the scattering T-matrix
appears for superconducting interactions of intermediate strength, within the
framework of a simple fermionic model. It is associated with a splitting of the
single peak in the spectral function into a pair of peaks separated by an
energy gap. Our physical picture is contrasted with that derived from other
T-matrix schemes, with superconducting fluctuation effects, and with preformed
pair (boson-fermion) models. Implications for photoemission and tunneling
experiments in the cuprates are discussed.Comment: REVTeX3.0; 4 pages, 4 EPS figures (included
Probing superconducting phase fluctuations from the current noise spectrum of pseudogaped metal-superconductor tunnel junctions
We study the current noise spectra of a tunnel junction of a metal with
strong pairing phase fluctuation and a superconductor. It is shown that there
is a characteristic peak in the noise spectrum at the intrinsic Josephson
frequency when is smaller than the pairing gap but
larger than the pairing scattering rate. In the presence of an AC voltage, the
tunnelling current noise shows a series of characteristic peaks with increasing
DC voltage. Experimental observation of these peaks will give direct evidence
of the pair fluctuation in the normal state of high- superconductors and
from the half width of the peaks the pair decay rate can be estimated.Comment: 4 pages, 3 figure
Magnetic Field Effects in the Pseudogap Phase: A Competing Energy Gap Scenario for Precursor Superconductivity
We study the sensitivity of T_c and T^* to low fields, H, within the
pseudogap state using a BCS-based approach extended to arbitrary coupling. We
find that T^* and T_c, which are of the same superconducting origin, have very
different H dependences. This is due to the pseudogap, \Delta_{pg}, which is
present at the latter, but not former temperature. Our results for the
coherence length \xi fit well with existing experiments.We predict that very
near the insulator \xi will rapidly increase.Comment: 4 pages, 4 figures, RevTe
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