Respiratory response to walking training in overweight men

The aim of the study was to follow up changes in physiological responses to incremental exercise after 4 weeks of moderate-intensity training in overweight men. Prior to the training, all subjects underwent 2 identical control tests (C1 and C2). Each test included three treadmill running exercises, starting at the treadmill speed of 4 km/h, and increased by 1 km/h at the end of each 4 min stage. The same protocol was repeated after 4 weeks of training (T1). The subjects’ body mass index was not changed after the training. Heart rate, oxygen uptake and blood pressure were significantly reduced in C2 as compared with C1 test. After 4 weeks of training the respiratory frequency (Rf), was lower than that in the C2 but a significant difference was noted only at the running speeds of 4 and 6kmhr-1 (P<0.04). Tidal volume (TV) increased after training in comparison with C2. A significant difference was found at the running speeds of 5 and 6 km/h (P<0.03 and P<0.04, respectively). Minute ventilation (VE) was not significantly different between the tests. The present study showed that in obese subjects 4 weeks of moderate uncontrolled walking training is advantageous for changes in the respiratory pattern. However, it is too short for the cardiovascular adaptation and body weight loss. Familiarization of the subjects with the experimental procedure diminished activation of the sympathetic nervous system and has a important role for the results interpretation

Intelligent Entity Behavior Within Synthetic Environments

This paper describes some elements in the development of realistic performance and behavior in the synthetic entities (players) which support Modeling and Simulation (M&S) applications, particularly military training. Modern human-in-the-loop (virtual) training systems incorporate sophisticated synthetic environments, which provide: 1. The operational environment, including, for example, terrain databases; 2. Physical entity parameters which define performance in engineered systems, such as aircraft aerodynamics; 3. Platform/system characteristics such as acoustic, IR and radar signatures; 4. Behavioral entity parameters which define interactive performance, including knowledge/reasoning about terrain, tactics; and, 5. Doctrine, which combines knowledge and tactics into behavior rule sets. The resolution and fidelity of these model/database elements can vary substantially, but as synthetic environments are designed to be compose able, attributes may easily be added (e.g., adding a new radar to an aircraft) or enhanced (e.g. Amending or replacing missile seeker head/ Electronic Counter Measures (ECM) models to improve the realism of their interaction). To a human in the loop with synthetic entities, their observed veridicality is assessed via engagement responses (e.g. effect of countermeasures upon a closing missile), as seen on systems displays, and visual (image) behavior. The realism of visual models in a simulation (level of detail as well as motion fidelity) remains a challenge in realistic articulation of elements such as vehicle antennae and turrets, or, with human figures; posture, joint articulation, response to uneven ground. Currently the adequacy of visual representation is more dependant upon the quality and resolution of the physical models driving those entities than graphics processing power per Se. Synthetic entities in M&S applications traditionally have represented engineered systems (e.g. aircraft) with human-in-the-loop performance characteristics (e.g. visual acuity) included in the system behavioral specification. As well, performance affecting human parameters such as experience level, fatigue and stress are coming into wider use (via AI approaches) to incorporate more uncertainty as to response type as well as performance (e.g. Where an opposing entity might go and what it might do, as well as how well it might perform)

Molecular perturbations in cholangiocarcinoma: is it time for precision medicine?

The complexity of cholangiocarcinoma (CCA) cellularity and the molecular perturbation mechanisms that underlie the diversity of growth patterns of this malignancy remain a clinical concern. Tumours of the biliary system display significant intrinsic chemoresistance, caused by significant stromal involvement and genome–wide tumour heterogeneity, hampering disease remission and palliation as well as promoting the metastatic behaviour. It is crucial to advance our present understanding of the risk and molecular pathogenesis of CCA. This will facilitate the delineation of patient subsets based on molecular perturbations and adjust for precision therapies

FUSE observations of hot white dwarfs

We have analyzed FUSE observations of six hot white dwarf stars: four DA white dwarfs with T_eff >= 45000K, the DAO Feige55 (T_eff = 55000K), and the DA CD -38 10980 (T_eff = 24000K). Photospheric lines from SiIV, PV, and SVI can be observed in the majority of the five hotter objects. Feige55 shows also several other heavier elements. The measured abundances agree only partly with the predictions of the radiative levitation theory. We attribute this to current limitations of the models and the probable presence of mass loss. In the spectrum of CD -38 10980, we have observed the quasi-molecular satellites of Lbeta. This confirms theoretical predictions about the visibility range for these features

The FUSE survey of OVI absorption in and near the Galaxy

We present FUSE observations of OVI absorption in a sample of 100 extragalactic targets and 2 distant halo stars. We describe the details of the calibration, alignment in velocity, continuum fitting, and manner in which contaminants were removed (Galactic H2, absorption intrinsic to the background target and intergalactic Ly-beta lines). We searched for OVI absorption in the velocity range -1200 to 1200 km/s. With a few exceptions, we only find OVI between -400 and 400 km/s; the exceptions may be intergalactic OVI. We discuss the separation of the observed OVI absorption into components associated with the Galactic halo and components at high-velocity, which are probably located in the neighborhood of the Galaxy. We describe the measurements of equivalent width and column density, and we analyze the different contributions to the errors. We conclude that low-velocity Galactic OVI absorption occurs along all sightlines - the few non-detections only occur in noisy spectra. We further show that high-velocity OVI is very common, having equivalent width >65 mAA in 50% of the sightlines and >30 mAA in 70% of the high-quality sightlines. The high-velocity OVI absorption has velocities relative to the LSR of +/-(100--330) km/s; there is no correlation between velocity and absorption strength. We present 50 km/s wide OVI channel maps. These show evidence for the imprint of Galactic rotation. They also highlight two known HI high-velocity clouds (complex~C and the Magellanic Stream). The channel maps further show that OVI at velocities <-200 km/s occurs along all sightlines in the region l=20-150, b200 km/s occurs along all sightlines in the region l=180-300, b>20 (abbreviated).Comment: 85 pages, 127 figures, 13 color figures, 3 tables, AASTeX preprint format. All figures are in PNG format due to space concerns. Bound copies of manuscript and two accompanying articles are available upon request. submitted to ApJ