11,974 research outputs found
The Dark Matter equation of state through cosmic history
Cold Dark Matter (CDM) is a crucial constituent of the current concordance
cosmological model. Having a vanishing equation of state (EoS), its energy
density scales with the inverse cosmic volume and is thus uniquely described by
a single number, its present abundance. We test the inverse cosmic volume law
for Dark Matter (DM) by allowing its EoS to vary independently in eight
redshift bins in the range and . We use the latest measurements
of the Cosmic Microwave Background radiation from the Planck satellite and
supplement them with Baryon Acoustic Oscillation (BAO) data from the 6dF and
SDSS-III BOSS surveys, and with the Hubble Space Telescope (HST) key project
data. We find no evidence for nonzero EoS in any of the eight redshift bins.
With Planck data alone, the DM abundance is most strongly constrained around
matter-radiation equality (95%
c.l.), whereas its present day value is more weakly constrained (95% c.l.). Adding BAO or HST data does not
significantly change the constraint, while
tightens to (95% c.l.) and
(95% c.l.) respectively. Our results constrain for the first time the level of
"coldness" required of the DM across various cosmological epochs and show that
the DM abundance is strictly positive at all times.Comment: 6 pages, 4 figures, changed color scheme for figure
Efficient numerical diagonalization of hermitian 3x3 matrices
A very common problem in science is the numerical diagonalization of
symmetric or hermitian 3x3 matrices. Since standard "black box" packages may be
too inefficient if the number of matrices is large, we study several
alternatives. We consider optimized implementations of the Jacobi, QL, and
Cuppen algorithms and compare them with an analytical method relying on
Cardano's formula for the eigenvalues and on vector cross products for the
eigenvectors. Jacobi is the most accurate, but also the slowest method, while
QL and Cuppen are good general purpose algorithms. The analytical algorithm
outperforms the others by more than a factor of 2, but becomes inaccurate or
may even fail completely if the matrix entries differ greatly in magnitude.
This can mostly be circumvented by using a hybrid method, which falls back to
QL if conditions are such that the analytical calculation might become too
inaccurate. For all algorithms, we give an overview of the underlying
mathematical ideas, and present detailed benchmark results. C and Fortran
implementations of our code are available for download from
http://www.mpi-hd.mpg.de/~globes/3x3/ .Comment: 13 pages, no figures, new hybrid algorithm added, matches published
version, typo in Eq. (39) corrected; software library available at
http://www.mpi-hd.mpg.de/~globes/3x3
Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators?
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription ( STAT) 3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone ( ACTH) secretion were determined. Results: Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor ( CNTF) and novel neurotrophin1/B-cell stimulating factor-3 (CNTFRalpha/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. Conclusion: (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIFR/gp130 (OSMR type I) but not OSMR/gp130 (OSMR type II) are involved in corticotroph signaling. (iv) CT-1 has the hitherto unknown ability to stimulate corticotroph function, and (v) despite redundant immuno-neuroendocrine effects of different gp130 cytokines, corticotroph cells are preferably activated through the LIFR and CNTFR complexes. Copyright (C) 2004 S. Karger AG, Basel
Real-Time Operating System/360
RTOS has a cost savings advantage for real-time applications, such as those with random inputs requiring a flexible data routing facility, display systems simplified by a device independent interface language, and complex applications needing added storage protection and data queuing
Aktuelle theoretische Ansätze und empirische Befunde im Bereich der Lehr-Lern-Forschung:Schwerpunkt Erwachsenenbildung
Das Gutachten dient dem im Jahr 2004 vom DIE ins Leben gerufenen „Expertenkreis Lehre in der Weiterbildung“ als Arbeitsgrundlage. Es stellt die aktuellen Ansätze und Befunde im Bereich des Lehrens und Lernens mit Schwerpunkt auf der Erwachsenenbildung dar. Neuere Ansätze zum Lehren und Lernen aus der Empirischen Pädagogik und Pädagogischen Psychologie werden vorgestellt und auf spezifische Aspekte der Weiterbildung wie Communities, berufliche Weiterbildung und Blended Learning eingegangen. Die verschiedenen Ebenen, Aufgabenfelder und Phasen des Bildungsmanagements werden beleuchtet und das Bildungscontrolling näher erläutert. Danach folgen Ausführungen zu einem mitarbeiterorientierten Implementationsmodell innovativer Lehr-Lern-Ansätze in Organisationen. Anhand der vorgestellten Ansätze und Befunde des Lehrens und Lernens werden Folgerungen für die Forschung und für die Ausund Weiterbildung der Lehrenden im Bereich der Erwachsenenbildung gezogen
Beam-Based Alignment of the NuMI Target Station Components at FNAL
The Neutrinos at the Main Injector (NuMI) facility is a conventional
horn-focused neutrino beam which produces muon neutrinos from a beam of mesons
directed into a long evacuated decay volume. The relative alignment of the
primary proton beam, target, and focusing horns affects the neutrino energy
spectrum delivered to experiments. This paper describes a check of the
alignment of these components using the proton beam.Comment: higher resolution figures available on Fermilab Preprint Server (see
SPIRES entry), accepted for publication in Nucl. Instr. and Meth.
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