299 research outputs found
Spectroscopic Target Selection in the Sloan Digital Sky Survey: The Quasar Sample
We describe the algorithm for selecting quasar candidates for optical
spectroscopy in the Sloan Digital Sky Survey. Quasar candidates are selected
via their non-stellar colors in "ugriz" broad-band photometry, and by matching
unresolved sources to the FIRST radio catalogs. The automated algorithm is
sensitive to quasars at all redshifts lower than z=5.8. Extended sources are
also targeted as low-redshift quasar candidates in order to investigate the
evolution of Active Galactic Nuclei (AGN) at the faint end of the luminosity
function. Nearly 95% of previously known quasars are recovered (based on 1540
quasars in 446 square degrees). The overall completeness, estimated from
simulated quasars, is expected to be over 90%, whereas the overall efficiency
(quasars:quasar candidates) is better than 65%. The selection algorithm targets
ultraviolet excess quasars to i^*=19.1 and higher-redshift (z>3) quasars to
i^*=20.2, yielding approximately 18 candidates per square degree. In addition
to selecting ``normal'' quasars, the design of the algorithm makes it sensitive
to atypical AGN such as Broad Absorption Line quasars and heavily reddened
quasars.Comment: 62 pages, 15 figures (8 color), 8 tables. Accepted by AJ. For a
version with higher quality color figures, see
http://archive.stsci.edu/sdss/quasartarget/RichardsGT_qsotarget.preprint.p
Physical and dynamical properties of the main belt triple asteroid (87) Sylvia
We present the analysis of high angular resolution observations of the triple
Asteroid (87) Sylvia collected with three 8-10 m class telescopes (Keck, VLT,
Gemini North) and the Hubble Space Telescope. The moons' mutual orbits were
derived individually using a purely Keplerian model. We computed the position
of Romulus, the outer moon of the system, at the epoch of a recent stellar
occultation which was successfully observed at less than 15 km from our
predicted position, within the uncertainty of our model. The occultation data
revealed that the Moon, with a surface-area equivalent diameter
Ds=23.10.7km, is strongly elongated (axes ratio of
2.70.32.70.3), significantly more than single asteroids of similar
size in the main-belt. We concluded that its shape is probably affected by the
tides from the primary. A new shape model of the primary was calculated
combining adaptive-optics observations with this occultation and 40 archived
light-curves recorded since 1978. The difference between the
J2=0.024-0.009+0.016 derived from the 3-D shape model assuming an homogeneous
distribution of mass for the volume equivalent diameter Dv=27310km primary
and the null J2 implied by the Keplerian orbits suggests a non-homogeneous mass
distribution in the asteroid's interior
Photometric Calibration of the Swift Ultraviolet/Optical Telescope
We present the photometric calibration of the Swift UltraViolet/Optical
Telescope (UVOT) which includes: optimum photometric and background apertures,
effective area curves, colour transformations, conversion factors for count
rates to flux, and the photometric zero points (which are accurate to better
than 4 per cent) for each of the seven UVOT broadband filters. The calibration
was performed with observations of standard stars and standard star fields that
represent a wide range of spectral star types. The calibration results include
the position dependent uniformity, and instrument response over the 1600-8000A
operational range. Because the UVOT is a photon counting instrument, we also
discuss the effect of coincidence loss on the calibration results. We provide
practical guidelines for using the calibration in UVOT data analysis. The
results presented here supersede previous calibration results.Comment: Minor improvements after referees report. Accepted for publication in
MNRA
Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock. The VANISH Randomized Clinical Trial
IMPORTANCE: Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative. OBJECTIVE: To compare the effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock. DESIGN, SETTING, AND PARTICIPANTS: A factorial (2Ă2), double-blind, randomized clinical trial conducted in 18 general adult intensive care units in the United Kingdom between February 2013 and May 2015, enrolling adult patients who had septic shock requiring vasopressors despite fluid resuscitation within a maximum of 6 hours after the onset of shock. INTERVENTIONS: Patients were randomly allocated to vasopressin (titrated up to 0.06 U/min) and hydrocortisone (nâ=â101), vasopressin and placebo (nâ=â104), norepinephrine and hydrocortisone (nâ=â101), or norepinephrine and placebo (nâ=â103). MAIN OUTCOMES AND MEASURES: The primary outcome was kidney failure-free days during the 28-day period after randomization, measured as (1) the proportion of patients who never developed kidney failure and (2) median number of days alive and free of kidney failure for patients who did not survive, who experienced kidney failure, or both. Rates of renal replacement therapy, mortality, and serious adverse events were secondary outcomes. RESULTS: A total of 409 patients (median age, 66 years; men, 58.2%) were included in the study, with a median time to study drug administration of 3.5 hours after diagnosis of shock. The number of survivors who never developed kidney failure was 94 of 165 patients (57.0%) in the vasopressin group and 93 of 157 patients (59.2%) in the norepinephrine group (difference, -2.3% [95% CI, -13.0% to 8.5%]). The median number of kidney failure-free days for patients who did not survive, who experienced kidney failure, or both was 9 days (interquartile range [IQR], 1 to -24) in the vasopressin group and 13 days (IQR, 1 to -25) in the norepinephrine group (difference, -4 days [95% CI, -11 to 5]). There was less use of renal replacement therapy in the vasopressin group than in the norepinephrine group (25.4% for vasopressin vs 35.3% for norepinephrine; difference, -9.9% [95% CI, -19.3% to -0.6%]). There was no significant difference in mortality rates between groups. In total, 22 of 205 patients (10.7%) had a serious adverse event in the vasopressin group vs 17 of 204 patients (8.3%) in the norepinephrine group (difference, 2.5% [95% CI, -3.3% to 8.2%]). CONCLUSIONS AND RELEVANCE: Among adults with septic shock, the early use of vasopressin compared with norepinephrine did not improve the number of kidney failure-free days. Although these findings do not support the use of vasopressin to replace norepinephrine as initial treatment in this situation, the confidence interval included a potential clinically important benefit for vasopressin, and larger trials may be warranted to assess this further. TRIAL REGISTRATION: clinicaltrials.gov Identifier: ISRCTN 20769191
Ecological genetics in the North Atlantic: environmental gradients and adaptation at specific loci
The North Atlantic intertidal community provides a rich set of organismal and environmental material for the study of ecological genetics. Clearly defined environmental gradients exist at multiple spatial scales: there are broad latitudinal trends in temperature, meso-scale changes in salinity along estuaries, and smaller scale gradients in desiccation and temperature spanning the intertidal range. The geology and geography of the American and European coasts provide natural replication of these gradients, allowing for population genetic analyses of parallel adaptation to environmental stress and heterogeneity. Statistical methods have been developed that provide genomic neutrality tests of population differentiation and aid in the process of candidate gene identification. In this paper, we review studies of marine organisms that illustrate associations between an environmental gradient and specific genetic markers. Such highly differentiated markers become candidate genes for adaptation to the environmental factors in question, but the functional significance of genetic variants must be comprehensively evaluated. We present a set of predictions about locus-specific selection across latitudinal, estuarine, and intertidal gradients that are likely to exist in the North Atlantic. We further present new data and analyses that support and contradict these simple selection models. Some taxa show pronounced clinal variation at certain loci against a background of mild clinal variation at many loci. These cases illustrate the procedures necessary for distinguishing selection driven by internal genomic vs. external environmental factors. We suggest that the North Atlantic intertidal community provides a model system for identifying genes that matter in ecology due to the clarity of the environmental stresses and an extensive experimental literature on ecological function. While these organisms are typically poor genetic and genomic models, advances in comparative genomics have provided access to molecular tools that can now be applied to taxa with well-defined ecologies. As many of the organisms we discuss have tight physiological limits driven by climatic factors, this synthesis of molecular population genetics with marine ecology could provide a sensitive means of assessing evolutionary responses to climate change
The Sloan Digital Sky Survey Quasar Catalog I. Early Data Release
We present the first edition of the Sloan Digital Sky Survey (SDSS) Quasar
Catalog. The catalog consists of the 3814 objects (3000 discovered by the SDSS)
in the initial SDSS public data release that have at least one emission line
with a full width at half maximum larger than 1000 km/s, luminosities brighter
than M_i^* = -23, and highly reliable redshifts. The area covered by the
catalog is 494 square degrees; the majority of the objects were found in SDSS
commissioning data using a multicolor selection technique. The quasar redshifts
range from 0.15 to 5.03. For each object the catalog presents positions
accurate to better than 0.2" rms per coordinate, five band (ugriz) CCD-based
photometry with typical accuracy of 0.05 mag, radio and X-ray emission
properties, and information on the morphology and selection method. Calibrated
spectra of all objects in the catalog, covering the wavelength region 3800 to
9200 Angstroms at a spectral resolution of 1800-2100, are also available. Since
the quasars were selected during the commissioning period, a time when the
quasar selection algorithm was undergoing frequent revisions, the sample is not
homogeneous and is not intended for statistical analysis.Comment: 27 pages, 4 figures, 4 tables, accepted by A
A GenomeâWide Association Study of NonâPhotochemical Quenching in response to local seasonal climates in Arabidopsis thaliana
Fieldâgrown plants have variable exposure to sunlight as a result of
shifting cloudâcover, seasonal changes, canopy shading, and other
environmental factors. As a result, they need to have developed a method
for dissipating excess energy obtained from periodic excessive sunlight
exposure. Nonâphotochemical quenching (NPQ) dissipates excess energy as
heat, however, the physical and molecular genetic mechanics of NPQ
variation are not understood. In this study, we investigated the genetic
loci involved in NPQ by first growing different Arabidopsis thaliana
accessions in local and seasonal climate conditions, then measured
their NPQ kinetics through development by chlorophyll fluorescence. We
used genomeâwide association studies (GWAS) to identify 15 significant
quantitative trait loci (QTL) for a range of photosynthetic traits,
including a QTL coâlocated with known NPQ gene PSBS (AT1G44575). We found there were large alternative regulatory segments between the PSBS
promoter regions of the functional haplotypes and a significant
difference in PsbS protein concentration. These findings parallel
studies in rice showing recurrent regulatory evolution of this gene. The
variation in the PSBS promoter and the changes underlying other
QTLs could give insight to allow manipulations of NPQ in crops to
improve their photosynthetic efficiency and yield.</p
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