88 research outputs found
High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells
Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases. Platelet hyperreactivity has been frequently found in patient with diabetes mellitus. To examine whether testosterone and high glucose modify platelet aggregation through endothelial cells, we did an in vitro study using endothelial cells culture from human umbilical vein (HUVEC). Treatments were performed in HUVEC sub culture as either normoglucose (5.6 mM) or high glucose (22.4 mM) medium, with or without testosterone (0, 1, 10, 100 nM), for 24 hours. HUVEC were trypsinized, resuspended, and then incubated with platelet rich plasma from healthy male donors with ratio 1:104 for 3 minutes. Platelet aggregation measured by turbidimetry methode. This study showed that testosterone did not significantly influence platelet aggregation through endothelial cells in normoglucose (p = 0.144) or high glucose (p = 0.916) medium. There was no main effect of testosterone (p = 0.73) as well as no interaction between testosterone and glucose (p = 0.69), but there was a main effect of glucose (p = 0.004), to platelet aggregation through endothelial cells. In conclusion, high glucose, but not testosterone, inhibits platelet aggregation mediated by endothelial cells
Large magneto-optical Kerr effect and imaging of magnetic octupole domains in an antiferromagnetic metal
When a polarized light beam is incident upon the surface of a magnetic
material, the reflected light undergoes a polarization rotation. This
magneto-optical Kerr effect (MOKE) has been intensively studied in a variety of
ferro- and ferrimagnetic materials because it provides a powerful probe for
electronic and magnetic properties as well as for various applications
including magneto-optical recording. Recently, there has been a surge of
interest in antiferromagnets (AFMs) as prospective spintronic materials for
high-density and ultrafast memory devices, owing to their vanishingly small
stray field and orders of magnitude faster spin dynamics compared to their
ferromagnetic counterparts. In fact, the MOKE has proven useful for the study
and application of the antiferromagnetic (AF) state. Although limited to
insulators, certain types of AFMs are known to exhibit a large MOKE, as they
are weak ferromagnets due to canting of the otherwise collinear spin structure.
Here we report the first observation of a large MOKE signal in an AF metal at
room temperature. In particular, we find that despite a vanishingly small
magnetization of 0.002 /Mn, the non-collinear AF metal
MnSn exhibits a large zero-field MOKE with a polar Kerr rotation angle of
20 milli-degrees, comparable to ferromagnetic metals. Our first-principles
calculations have clarified that ferroic ordering of magnetic octupoles in the
non-collinear Neel state may cause a large MOKE even in its fully compensated
AF state without spin magnetization. This large MOKE further allows imaging of
the magnetic octupole domains and their reversal induced by magnetic field. The
observation of a large MOKE in an AF metal should open new avenues for the
study of domain dynamics as well as spintronics using AFMs.Comment: 30 pages, 4 figure
Symmetry and topology in antiferromagnetic spintronics
Antiferromagnetic spintronics focuses on investigating and using
antiferromagnets as active elements in spintronics structures. Last decade
advances in relativistic spintronics led to the discovery of the staggered,
current-induced field in antiferromagnets. The corresponding N\'{e}el
spin-orbit torque allowed for efficient electrical switching of
antiferromagnetic moments and, in combination with electrical readout, for the
demonstration of experimental antiferromagnetic memory devices. In parallel,
the anomalous Hall effect was predicted and subsequently observed in
antiferromagnets. A new field of spintronics based on antiferromagnets has
emerged. We will focus here on the introduction into the most significant
discoveries which shaped the field together with a more recent spin-off
focusing on combining antiferromagnetic spintronics with topological effects,
such as antiferromagnetic topological semimetals and insulators, and the
interplay of antiferromagnetism, topology, and superconductivity in
heterostructures.Comment: Book chapte
Fluorescent Pigment and Phenol Glucosides from the Heartwood of Pterocarpus marsupium
The fluorescence shown by extracts of the heartwood of
Pterocarpus marsupium is attributed to salts of the new compound 1,
whose structure was elaborated using detailed spectroscopic/
spectrometric studies. The plant material also contains the nonfluorescent
compounds 2 and 3. The absolute configuration of 1 was determined
by experimental and theoretically calculated electronic CD spectra,
while that of 3 was deduced from ECD comparison with reported results
in the α-hydroxydihydrochalcone series
The psychological science accelerator’s COVID-19 rapid-response dataset
In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data
A global experiment on motivating social distancing during the COVID-19 pandemic
Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges
Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.
The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not yet well understood. In this study, we describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories. We show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished after the early introduction of international travel restrictions. As the pandemic progressed, ongoing transmission in many countries and increasing mobility led to the emergence and spread within the continent of many variants of concern and interest, such as B.1.351, B.1.525, A.23.1, and C.1.1. Although distorted by low sampling numbers and blind spots, the findings highlight that Africa must not be left behind in the global pandemic response, otherwise it could become a source for new variants
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