Canonical Forms in Interactive Exercise Assistants

Interactive exercise assistants support students in practicing exercises, and acquiring procedural skills. Many mathematical topics can be practiced in such assistants. Ideally, an interactive exercise assistant not only validates final answers, but also comments on intermediate steps submitted by a student, provides hints on how to proceed, and presents worked-out examples. For these purposes, fine control over the symbolic simplification procedures of the underlying mathematical machinery is needed. In this paper, we introduce views for mathematical expressions. A view defines an equivalence relation by choosing a canonical form of mathematical expressions. We use views to track and recognize intermediate answers, to help in presenting expressions to a user, and to control the granularity of the steps in worked-out examples. We develop the concept of a view, discuss the laws it satisfies, and show how views are composed, which means that they can be used for multiple exercise classes.

Использование терминообразующего потенциала классических языков современными языками (на примере экономической терминологии современного французского языка)

It is imperative to fascinate young children at an early stage in their education for the analytical sciences. The exposure of the public to mass spectrometry presently increases rapidly through the common media. Outreach activities can take advantage of this exposure and employ mass spectrometry as an exquisite example of an analytical science in which children can be fascinated. The presented teaching modules introduce children to mass spectrometry and give them the opportunity to experience a modern research laboratory. The modules are highly adaptable and can be applied to young children from the age of 6 to 14 y. In an interactive tour, the students explore three major scientific concepts related to mass spectrometry; the building blocks of matter, charged particle manipulation by electrostatic fields, and analyte identification by mass analysis. Also, the students carry out a mass spectrometry experiment and learn to interpret the resulting mass spectra. The multistage, inquiry-based tour contains flexible methods, which teach the students current-day research techniques and possible applications to real research topics. Besides the scientific concepts, laboratory safety and hygiene are stressed and the students are enthused for the analytical sciences by participating in “hands-on” work. The presented modules have repeatedly been successfully employed during laboratory open days. They are also found to be extremely suitable for (early) high school science classes during laboratory visit-focused field trips

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development

Chorioamnionitis is associated with adverse neurodevelopmental outcomes in preterm infants. Ureaplasma spp. are the microorganisms most frequently isolated from the amniotic fluid of women diagnosed with chorioamnionitis. However, controversy remains concerning the role of Ureaplasma spp. in the pathogenesis of neonatal brain injury. We hypothesize that re-exposure to an inflammatory trigger during the perinatal period might be responsible for the variation in brain outcome of preterms following Ureaplasma driven chorioamnionitis. To investigate these clinical scenarios, we performed a detailed multi-modal study in which ovine neurodevelopmental outcomes were assessed following chronic intra-amniotic Ureaplasma parvum (UP) infection, either alone or combined with subsequent lipopolysaccharide (LPS) exposure. We show that chronic intra-amniotic UP exposure during the second trimester provoked a decrease of astrocytes, increased oligodendrocyte numbers and elevated 5-methylcytosine levels. In contrast, short-term LPS exposure before preterm birth induced increased microglial activation, myelin loss, elevation of 5-hydroxymethylcytosine levels and lipid profile changes. These LPS-induced changes were prevented by chronic pre-exposure to UP (preconditioning). These data indicate that chronic UP exposure provokes dual effects on preterm brain development in utero. On one hand, prolonged UP exposure causes detrimental cerebral changes which may predispose to adverse postnatal clinical outcomes. On the other, chronic intra-amniotic UP exposure preconditions the brain against a second inflammatory hit. This study demonstrates that microbial interactions, timing and duration of inflammatory insults will determine the effects on the fetal brain. Therefore, this study helps to understand the complex and diverse postnatal neurological outcomes following UP driven chorioamnionitis

Health promotion: results of focus groups with African-American men

http://dx.doi.org/10.1016/j.jomh.2010.11.00

Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET: The Optimal Sequence in Preoperative Staging of Esophageal Cancer?

Background: The separate value of endoscopic ultrasonography (EUS), multidetector computed tomography (CT), and18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in the optimal sequence in staging esophageal cancer has not been investigated adequately. Methods: The staging records of 216 consecutive operable patients with esophageal cancer were reviewed blindly. Different staging strategies were analyzed, and the likelihood ratio (LR) of each module was calculated conditionally on individual patient characteristics. A logistic regression approach was used to determine the most favorable staging strategy. Results: Initial EUS results were not significantly related to the LRs of initial CT and FDG-PET results. The positive LR (LR+) of EUS-fine-needle aspiration (FNA) was 4, irrespective of CT and FDG-PET outcomes. The LR+ of FDG-PET varied from 13 (negative CT) to 6 (positive CT). The LR+ of CT ranged from 3-4 (negative FDG-PET) to 2-3 (positive FDG-PET). Age, histology, and tumor length had no significant impact on the LRs of the three diagnostic tests. Conclusions: This study argues in favor of PET/CT rather than EUS as a predictor of curative resectability in esophageal cancer. EUS does not correspond with either CT or FDG-PET. LRs of FDG-PET were substantially different between subgroups of negative and positive CT results and vice versa

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

Chorioamnionitis, clinically most frequently associated with Ureaplasma, is linked to intestinal inflammation and subsequent gut injury. No treatment is available to prevent chorioamnionitis-driven adverse intestinal outcomes. Evidence is increasing that plant sterols possess immune-modulatory properties. Therefore, we investigated the potential therapeutic effects of plant sterols in lambs intra-amniotically (IA) exposed to Ureaplasma. Fetal lambs were IA exposed to Ureaplasma parvum (U. parvum, UP) for six days from 127 d–133 d of gestational age (GA). The plant sterols β-sitosterol and campesterol, dissolved with β-cyclodextrin (carrier), were given IA every two days from 122 d–131 d GA. Fetal circulatory cytokine levels, gut inflammation, intestinal injury, enterocyte maturation, and mucosal phospholipid and bile acid profiles were measured at 133 d GA (term 150 d). IA plant sterol administration blocked a fetal inflammatory response syndrome. Plant sterols reduced intestinal accumulation of proinflammatory phospholipids and tended to prevent mucosal myeloperoxidase-positive (MPO) cell influx, indicating an inhibition of gut inflammation. IA administration of plant sterols and carrier diminished intestinal mucosal damage, stimulated maturation of the immature epithelium, and partially prevented U. parvum-driven reduction of mucosal bile acids. In conclusion, we show that β-sitosterol and campesterol administration protected the fetus against adverse gut outcomes following UP-driven chorioamnionitis by preventing intestinal and systemic inflammation

Ghosthunting and vulgar news: popular realities on recent Indonesian television

Javaans taalgebruik: artistiek en alledaag

Field evidence of a natural capillary barrier in a gravel alluvial aquifer

Ozark streams commonly feature “composite” floodplains, in which the vadose zone consists of silt or silt loam soils (?1 m thick) overlying gravel subsoil. Previous work has shown that preferential flow paths can exist within the gravel subsoil, which can conduct water and P at rates exceeding the sorption capacity of the gravel. At a site on Barren Fork Creek, a 1- by 1-m infiltration plot was constructed and an infiltration experiment was performed using sequentially introduced solutes including P (the constituent of regulatory interest), Rhodamine-WT (Rh-WT, a visual tracer), and Cl− (an electrical tracer). The solute transport was measured with monitoring wells (MWs) placed 1 m from the plot boundary and 5 m down the groundwater flow gradient using an electrical resistivity imaging (ERI) array. The ERI method utilized differences between a pre-infiltration background image and subsequent temporal images taken during the test to quantify changes induced by the tracers. The infiltration test maintained a steady-state flow rate of 4.5 L min−1 for 84.75 h. Electrical resistivity imaging data showed significant changes in resistivity induced by the tracers within the soil vadose zone under the plot but no similar changes within the gravel, indicating that the interface was acting as a capillary barrier. Electrical resistivity images 5 m away from the plot showed tracer breakthrough into the gravel in areas not sampled by the MWs. Solute detection was limited in MWs, indicating that MWs could not adequately monitor movement below the capillary barrier because it controlled migration of solute to the heterogeneous phreatic zone

A geospatial variable rate irrigation control scenario evaluation methodology based on mining root zone available water capacity

Increasing concern for sustainable water use has the agriculture industry working toward higher efficiency in use of irrigation water. Recent advancements have improved the capabilities of center pivot irrigation systems to vary water application depths across the field, a technology known as variable rate irrigation (VRI). The goal of this study was to provide a geospatial method for potential VRI technology adopters to evaluate control scenarios and potential water savings using freely available datasets. Root zone available water capacity (R) was estimated spatially across two case study fields using the Natural Resources Conservation Service Gridded Soil Survey Geographic Database. The difference in application depth between conventional irrigation (CI) and both sector and zone control VRI was then estimated based on R. Prescription maps were developed to mine undepleted soil water from each irrigation management zone based on a soil water balance approach with a management-allowed depletion of 50%. For CI management, the areal 10th percentile (PCTL) of R for the field was used, while for VRI the 10th PCTL of R for each management zone was used. The highest reduction in irrigation depth was 18 mm where higher values of R were estimated; however, field average reductions ranged from 0 to 12 mm. The greatest improvements in pumpage reduction resulted from converting from sector control to zone control, while increasing the angular resolution only had a minor impact. Energy savings generally increased with higher VRI control resolution. Conclusions support previous notions that VRI may result in small pumping water reductions for some fields; however, improved water distribution may be achieved throughout the field