116 research outputs found
Geotechnical Field Reconnaissance: Gorkha (Nepal) Earthquake of April 25, 2015 and Related Shaking Sequence
The April 25, 2015 Gorkha (Nepal) Earthquake and its related aftershocks had a devastating impact on Nepal. The earthquake sequence resulted in nearly 9,000 deaths, tens of thousands of injuries, and has left hundreds of thousands of inhabitants homeless. With economic losses estimated at several billion US dollars, the financial impact to Nepal is severe and the rebuilding phase will likely span many years. The Geotechnical Extreme Events Reconnaissance (GEER) Association assembled a reconnaissance team under the leadership of D. Scott Kieffer, Binod Tiwari and Youssef M.A. Hashash to evaluate geotechnical impacts of the April 25, 2015 Gorkha Earthquake and its related aftershocks. The focus of the reconnaissance was on time-sensitive (perishable) data, and the GEER team included a large group of experts in the areas of Geology, Engineering Geology, Seismology, Tectonics, Geotechnical Engineering, Geotechnical Earthquake Engineering, and Civil and Environmental Engineering. The GEER team worked in close collaboration with local and international organizations to document earthquake damage and identify targets for detailed follow up investigations. The overall distribution of damage relative to the April 25, 2015 epicenter indicates significant ground motion directivity, with pronounced damage to the east and comparatively little damage to the west. In the Kathmandu Basin, characteristics of recorded strong ground motion data suggest that a combination of directivity and deep basin effects resulted in significant amplification at a period of approximately five seconds. Along the margins of Kathmandu Basin structural damage and ground failures are more pronounced than in the basin interior, indicating possible basin edge motion amplification. Although modern buildings constructed within the basin generally performed well, local occurrences of heavy damage and collapse of reinforced concrete structures were observed. Ground failures in the basin included cyclic failure of silty clay, lateral spreading and liquefaction. Significant landsliding was triggered over a broad area, with concentrated activity east of the April 25, 2015 epicenter and between Kathmandu and the Nepal-China border. The distribution of concentrated landsliding partially reflects directivity in the ground motion. Several landslides have dammed rivers and many of these features have already been breached. Hydropower is a primary source of electric power in Nepal, and several facilities were damaged due to earthquake-induced landsliding. Powerhouses and penstocks experienced significant damage, and an intake structure currently under construction experienced significant dynamic settlement during the earthquake. Damage to roadways, bridges and retaining structures was also primarily related to landsliding. The greater concentration of infrastructure damage along steep hillsides, ridges and mountain peaks offers a proxy for the occurrence of topographic amplification. The lack of available strong motion records has severely limited the GEER teamâs ability to understand how strong motions were distributed and how they correlate to distributions of landsliding, ground failure and infrastructure damage. It is imperative that the engineering and scientific community continues to install strong motion stations so that such data is available for future earthquake events. Such information will benefit the people of Nepal through improved approaches to earthquake resilient design
Geotechnical Effects of the 2015 Magnitude 7.8 Gorkha, Nepal, Earthquake and Aftershocks
This article summarizes the geotechnical effects of the 25 April 2015 M 7.8 Gorkha, Nepal, earthquake and aftershocks, as documented by a reconnaissance team that undertook a broad engineering and scientific assessment of the damage and collected perishable data for future analysis. Brief descriptions are provided of ground shaking, surface fault rupture, landsliding, soil failure, and infrastructure performance. The goal of this reconnaissance effort, led by Geotechnical Extreme Events Reconnaissance, is to learn from earthquakes and mitigate hazards in future earthquakes
MIR-99a and MIR-99b Modulate TGF-ÎČ Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells
Epithelial to mesenchymal transition (EMT) is a key process during embryonic development and disease development and progression. During EMT, epithelial cells lose epithelial features and express mesenchymal cell markers, which correlate with increased cell migration and invasion. Transforming growth factor-ÎČ (TGF-ÎČ) is a multifunctional cytokine that induces EMT in multiple cell types. The TGF-ÎČ pathway is regulated by microRNAs (miRNAs), which are small non-coding RNAs regulating the translation of specific messenger RNAs
Maternal DNA Methylation Regulates Early Trophoblast Development
This work was funded by the BBSRC, Wellcome Trust, MRC, the EC Network of Excellence EpiGeneSys, the EC BLUEPRINT project, the Centre for Trophoblast Research, and CIHR (grant MOP-119357 to L.L.). M.R.B. is a Sir Henry Dale Fellow (101225/Z/13/Z), jointly funded by the Wellcome Trust and the Royal Society
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Geotechnical Effects of the 2015 Magnitude 7.8 Gorkha, Nepal, Earthquake and Aftershocks
This article summarizes the geotechnical effects of the 25 April 2015 M 7.8 Gorkha, Nepal, earthquake and aftershocks, as documented by a reconnaissance team that undertook a broad engineering and scientific assessment of the damage and collected perishable data for future analysis. Brief descriptions are provided of ground shaking, surface fault rupture, landsliding, soil failure, and infrastructure performance. The goal of this reconnaissance effort, led by Geotechnical Extreme Events Reconnaissance, is to learn from earthquakes and mitigate hazards in future earthquakes.This is the publisherâs final pdf. The published article is copyrighted by Seismological Society of America and can be found at: http://www.seismosoc.org/publications/srl
Cross-border trafficking in human beings: prevention and intervention strategies for reducing sexual exploitation
Over the years, growing attention has been given to the phenomenon of trafficking in human beings (THB). Sexual exploitation was until recently by far the most commonly identified feature of THB, followed by forced labour. Many activities to combat trafficking for the purpose of sexual exploitation have been initiated by numerous supranational, international as well as national organizations. Much is written about these initiatives, but some areas have been neglected. Knowledge on âwhat worksâ is in particular limited. The growing attention to THB entails a demand for more information. The severity of the crime and the impact on its victims makes it of utmost importance to gain more insight into the working and effectiveness of anti-trafficking strategies and interventions. The main objective of this review was to assess the presently available evidence on the effects of interventions that aim to prevent and suppress trafficking in human beings
The Maule (Chile) Earthquake of February 27, 2010: Consequence Assessment and Case Studies
On February 27, 2010 at 03:34 am local time, a powerful earthquake of
magnitude 8.8 struck central Chile. The epicenter of the earthquake was
approximately 8 km off the central region of the Chilean coast. With an inclined
rupture area of more than 80,000 square km that extends onshore, the region of
Maule was subjected to a direct hit, with intense shaking of duration of at least
100 seconds, and peak horizontal and vertical ground acceleration of over 0.6
g. The earthquake caused the death of 521 persons, with almost half of the
fatalities caused by the consequential tsunami. Over 800,000 individuals were
directly affected through death, injury and displacement. More than a third of a
million buildings were damaged to varying degrees, including several cases of
total collapse of major structures. The transportation system was dealt a
crippling blow, with 830 failures registered with the Ministry of Public Works on
roads in both the public and private transportation networks. Disruption of
commerce as well as the rescue and response effort resulted from the damage
to roads, embankments and bridges. On the whole, the performance of
engineered structures was reasonable, taking into account the magnitude and
proximity of the earthquake. The latter conclusion is supported by the
observations from several back-analyses presented in this report. Damage to
non-engineered construction is as expected in major earthquakes. Most
reinforced concrete bridges behaved well.
The role of social networking tools in enabling the affected population to
communicate was a most interesting feature in the response to this
earthquake. Due to the failure of the power grid, and the congestion of the
cellphone network, the population resorted to short message service and web
social media. Ham radio networks were activated to fill gaps due to the failure
of the radio network in places. The failure in ham radio broadcast in coastal
regions might have increased the fatalities because tsunami warning did not
reach all hazardous locations.
The MAE Center field reconnaissance team members consider that Chilean
engineering was proven to be robust and that seismic design provisions and
construction practices are of high standard. The extensive damage from this
Mw = 8.8 earthquake is expected and within the ???life safety??? performance target
of seismic design codes.National Science Foundation EEC-9701785unpublishednot peer reviewe
Numerical analysis of the support system in the transition zone of the Esfahan subway project
This paper presents the design and 3D numerical modeling of the temporary support system for the twin tunnels in the transition zone of the Esfahan subway project. Ground movements caused by tunneling beneath urban areas can have a significant impact on adjacent structures and therefore require consideration when choosing the excavation method and the type of support system. Due to the old buildings in the historical city of Esfahan, this research requires parametric studies for the use of simulation techniques. This paper focuses on 3D stability analysis and design of the support system required to control the critical strain and ground movement due to excavation of the transition area of the twin tunnels in the Esfahan subway project. A numerical model is developed to estimate the excavation effects on the critical strain and ground settlement and also the effect of reinforcement measures. In the 3D numerical model, a constitutive law characterized by the time-dependent stiffness and strength of the shotcrete is employed. Results show that the suggested support is sufficient to control the settlement and critical strain due to tunneling. Comparison between the 2D model prediction and the results of corresponding 3D model indicates that the conformity between 2D and 3D analysis results decreases in the transition region. One of the most useful methods to determine the induced seismic loads, the use of time-history dynamic analysis is usually done for major projects. In this paper, for the twin tunnels of subway, Fast Lagrangian Analysis of Continua (FLAC) software is used for this purpose. © 2014 Saudi Society for Geosciences
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