Rhegmatogenous retinal detachment masquerading as exudative panuveitis with intense anterior chamber inflammatory reaction.

Purpose:This is a retrospective case report illustrating the diagnostic and therapeutic challenges associated with a chronic rhegmatogenous retinal detachment masquerading as a severe panuveitis with intense anterior chamber inflammation. We have included clinical features, anterior segment and fundus photography, B-scan ultrasonography, fluorescein angiography, and intraoperative findings. Observations:A 26-year-old male presented with features of unilateral panuveitis: hypotony, anterior segment inflammation (posterior synechiae and anterior chamber cell with fibrin clumping), diffuse choroidal thickening, and retinal detachment. Laboratory investigations for infectious or rheumatologic processes were negative, and empiric systemic corticosteroid therapy was unsuccessful. This prompted suspicion for an alternate primary etiology, and pars plana vitrectomy revealed small retinal breaks as the underlying cause of the retinal detachment and inflammation. Conclusions:Rhegmatogenous retinal detachments are a known cause of intraocular inflammation. Nevertheless, it remains a challenge to recognize retinal breaks in this setting, particularly with robust anterior segment inflammation and posterior findings resembling severe exudative uveitis. Being aware of this unique presentation may prevent delays in diagnosis and have important prognostic implications

Relation between TMAOase activity and content of formaldehyde in fillet minces and bellyflap minces from gadoid fishes

Minced fish is a significant component of a number of frozen fishery products like fish fingers, cakes and patties. Predominately minced fish is produced from gadoid species (Alaska pollack, cod, saithe, hake and others) possessing the enzyme trimethylamine oxide demethylase (TMAOase, E.C. 4.1.2.32) (Rehbein and Schreiber 1984). TMAOase catalyses the degradation of trimethylamine oxide (TMAO) to formaldehyde (FA) and dimethylamine (DMA), preferentially during frozen storage of products (Hultin 1992). In most gadoid species light muscle contains only low activity of TMAOase, the activity of red muscle and bellyflaps being somewhat higher. In contrast, the TMAOase activity in blood, kidney and other tissues, residues of which may contaminate minced fish flesh, may be higher for several orders of magnitude (Rehbein and Schreiber 1984)

Left-right symmetric model with μ↔τ\mu\leftrightarrow\tau symmetry

We analyze the leptonic sector in the left-right symmetric model dressed with a $(Z_{2})^{3}$ discrete symmetry which realizes, after weak spontaneous breaking, a small broken \mu\lra\tau symmetry that is suggested to explain observable neutrino oscillation data. \mu\lra\tau symmetry is broken at tree level in the effective neutrino mass matrix due to the mass difference $\widetilde{m}_{\tau}\neq \widetilde{m}_{\mu}$ in the diagonal Dirac mass terms, whereas all lepton mixings arise from a Majorana mass matrix. In the limit of a small breaking we determined $\theta_{13}$, and the deviation from the maximal value of $\theta_{ATM}$, in terms of the light neutrino hierarchy scale, $m_{3}$, and a single free parameter $h_{s}$ of the model.Comment: 9 pages, 4 figures. Title changed and we have added one new section: CP phase contribution. Minor corrections and references updated. Published versio

Adjuvants : an essential component of neisseria vaccines

Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis caused by Neisseria meningitidis serogroups, particularly serogroup B, continues to be a global health problem. Novel strategies have applied in silico and recombinant technologies to develop "universal" antigens (e.g. proteins, peptides and plasmid DNA) for vaccines, but these antigens have been shown to be poorly immunogenic even when alum adjuvanted, implying a need for better vaccine design. In this work we review the use of natural, detoxified, or synthetic molecules in combination with antigens to activate the innate immune system and to modulate the adaptive immune responses. In the main, antigenic and imune potentiator signals are delivered using nano-, micro-particles, alum, or emulsions. The importance of interaction between adjuvants and antigens to activate and target dendritic cells, the bridge between the innate and adaptive immune systems, will be discussed. In addition, nasal vaccine strategies based on the development of mucosal adjuvants and Neisseria derivatives to eliminate the pathogen at the site of infection provide promising adjuvants effective not only against respiratory pathogens, but also against pathogens responsible for enteric and sexually transmitted diseases

Two Years Later and Counting: The Implications of the Supreme Court’s Taxing Power Decision on the Goals of the Affordable Care Act

In 2012, in a highly anticipated decision, the United States Supreme Court upheld the constitutionality of a requirement that most Americans obtain health insurance or pay a monetary penalty.\u27 The statute in question that contained this requirement, the Patient Protection and Affordable Care Act (Act or ACA), often labeled as Obamacare, or the Affordable Care Act, was a monumental piece of legislation (over 900 pages) that was passed by Congress and signed into law by President Barack Obama in 2010. The Act represented a significant overhaul of the country\u27s health care system and structure. The primary objectives of this legislation were to expand the number of individuals covered by health insurance and decrease the overall cost of health care in the country. In the 2012 elections, President Obama won re-election and Senate democrats strengthened their majority in the U.S. Senate. Consequently, many experts believed the Act was here to stay; however, questions remain regarding its implementation. Although the Supreme Court essentially ended two years of uncertainty on the legal status of the Act, it is now unclear whether the original goals of the Act and the individual mandate adding millions of new consumers to the health insurance market and increasing the number and share of Americans who are insured can still be met. This article explores the Court\u27s taxing power decision with respect to the individual mandate and the direct implications of that decision to not only the Act\u27s objectives for greater individual health insurance coverage, but also the possible impact in other health care areas. Two years after the Court\u27s decision, the Act\u27s overall implementation is still uncertain. As states work to implement the Act or choose to maintain their own healthcare models, the healthcare market is in a state of flux. Due partially to the Court\u27s decision to restrict the Medicaid expansion, the Act\u27s effectiveness is now more questionable than ever. Questions addressed by this Article include whether there really still is a legal individual mandate requiring the purchase of health insurance and whether further legislation could be possible under Congress\u27s taxing power if the goals under the Act are not met. This article also reviews the question of whether there has been an expansion of Congress\u27s taxing power, along with an analysis of current efforts at implementation and consideration of whether the Court\u27s decision may ultimately have done more harm than good to the individual mandate

Maximum-likelihood models for mapping genetic markers showing segregation distortion : 2. F2 populations

Dans la génération F2, la sélection naturelle des gamètes et des zygotes peut affecter les linkages génétiques. Une équation mathématique qui prend toutes les probabibilités de linkage en compte est développée. L'intégration des marqueurs génétiques dominants et codominants permet d'obtenir une courbe de probabilité asymptotique. La comparaison de l'utilité et de la précision des modèles montre que la prise en compte des marqueurs dominants seuls ne donne pas assez d'information sur le cas de distorsions de ségrégation. L'estimation de la fraction de recombinaisons entre les marqueurs codominants est peu affectée par la sélection, ce qui n'est pas le cas pour les marqueurs dominant