308 research outputs found
Scraping the Social? Issues in live social research
What makes scraping methodologically interesting for social and cultural research? This paper seeks to contribute to debates about digital social research by exploring how a ‘medium-specific’ technique for online data capture may be rendered analytically productive for social research. As a device that is currently being imported into social research, scraping has the capacity to re-structure social research, and this in at least two ways. Firstly, as a technique that is not native to social research, scraping risks to introduce ‘alien’ methodological assumptions into social research (such as an pre-occupation with freshness). Secondly, to scrape is to risk importing into our inquiry categories that are prevalent in the social practices enabled by the media: scraping makes available already formatted data for social research. Scraped data, and online social data more generally, tend to come with ‘external’ analytics already built-in. This circumstance is often approached as a ‘problem’ with online data capture, but we propose it may be turned into virtue, insofar as data formats that have currency in the areas under scrutiny may serve as a source of social data themselves. Scraping, we propose, makes it possible to render traffic between the object and process of social research analytically productive. It enables a form of ‘real-time’ social research, in which the formats and life cycles of online data may lend structure to the analytic objects and findings of social research. By way of a conclusion, we demonstrate this point in an exercise of online issue profiling, and more particularly, by relying on Twitter to profile the issue of ‘austerity’. Here we distinguish between two forms of real-time research, those dedicated to monitoring live content (which terms are current?) and those concerned with analysing the liveliness of issues (which topics are happening?)
A teoria dinâmica do conhecimento de Duhem: um termo médio entre a concepção metafÃsica clássica da ciência e a concepção do convencionalismo/pragmatismo (Poincaré)
Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy
The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-α is highly expressed in oxidative skeletal muscle and plays a role in mitochondrial biogenesis and oxidative function, in gain- and loss-of function studies. Rev-erb-α-deficiency in skeletal muscle leads to reduced mitochondrial content and oxidative function, resulting in compromised exercise capacity. This phenotype was recapitulated in isolated fibers and in muscle cells upon Rev-erbα knock-down, while Rev-erb-α over-expression increased the number of mitochondria with improved respiratory capacity. Rev-erb-α-deficiency resulted in deactivation of the Stk11–Ampk–Sirt1–Ppargc1-α signaling pathway, whereas autophagy was up-regulated, resulting in both impaired mitochondrial biogenesis and increased clearance. Muscle over-expression or pharmacological activation of Rev-erb-α increased respiration and exercise capacity. This study identifies Rev-erb-α as a pharmacological target which improves muscle oxidative function by modulating gene networks controlling mitochondrial number and function
Linking the subcultures of physics: Virtual empiricism and the bonding role of trust
This article draws on empirical material concerning the communication and use of knowledge in experimental physics and their relations to the culture of theoretical physics. The role that trust plays in these interactions is used to create a model of social distance between interacting theoretical and experimental cultures. This article thus seeks to reintroduce trust as a fundamental element in answering the problem of disunity in the sociology of knowledge
Uma reconstrução racional do programa de pesquisa do racionalismo neoclássico: os subprogramas do convencionalismo/pragmatismo (Poincaré) e do realismo estrutural convergente (Duhem)
A fresh look at instrumentation - an introduction
The theme of "instrumentation between science, state and industry" does not square well with the venerable discourse which opposes "science" and "technology" in social studies of science. In this discourse, "technology" stands for the contrary of "science"; it represents the practical uses of science in society at large and is understood as separate from the somehow autonomous sphere of "science" (Layton 1971a). This vocabulary, widespread as it may be, is not very useful for our purposes, and, for that matter, for any inquiry into the role of instruments. Technology, in the sense of technical instruments and the knowledge systems that go with them, pervades all societal systems. There are technologies of science, of industry, of state, and so forth, and it would be ill-advised to assume that, in the end, they all flow out of "science." But even if the crude opposition of science and technology has little analytic value, the dual problem remains: how to effectively conceive the dynamic relationship between scientific spheres and other societal spheres, and how to conceive the role that technological matters play in this relationship
On being a good Bayesian
Bayesianism is fast becoming the dominant paradigm in archaeological chronology construction. This paradigm shift has been brought about in large part by widespread access to tailored computer software which provides users with powerful tools for complex statistical inference with little need to learn about statistical modelling or computer programming. As a result, we run the risk that such software will be reduced to the status of black boxes. This would be a dangerous position for our community since good, principled use of Bayesian methods requires mindfulness when selecting the initial model, defining prior information, checking the reliability and sensitivity of the software runs and interpreting the results obtained. In this article, we provide users with a brief review of the nature of the care required and offer some comments and suggestions to help ensure that our community continues to be respected for its philosophically rigorous scientific approach
Fungal biodiversity profiles 21–30
The authors describe ten new taxa for science using mostly both morphological and molecular data. In Basidiomycota, descriptions are provided for Botryobasidium fusisporum sp. nov., B. triangulosporum sp. nov., Cantharellus hydnoides sp. nov. and Hydnum aerostatisporum sp. nov. in Cantharellales; Lactarius rahjamalensis sp. nov. and Russula pseudoaurantiophylla sp. nov. in Russulales and for Mycena paraguayensis comb. nov. in Agaricales. In Ascomycota and hyphomycetes, descriptions are provided for Colletotrichurn eryngiicola sp. nov. (Glomerellales), Corynesporella indica sp. nov. (incertae sedis) and Repetophragma zygopetali sp. nov. (Microthyriales)
Experimental demonstration of extended depth-of-field f/1.2 visible High Definition camera with jointly optimized phase mask and real-time digital processing
Increasing the depth of field (DOF) of compact visible high resolution cameras while maintaining high imaging performance in the DOF range is crucial for such applications as night vision goggles or industrial inspection. In this paper, we present the end-to-end design and experimental validation of an extended depth-of-field visible High Definition camera with a very small f-number, combining a six-ring pyramidal phase mask in the aperture stop of the lens with a digital deconvolution. The phase mask and the deconvolution algorithm are jointly optimized during the design step so as to maximize the quality of the deconvolved image over the DOF range. The deconvolution processing is implemented in real-time on a Field-Programmable Gate Array and we show that it requires very low power consumption. By mean of MTF measurements and imaging experiments we experimentally characterize the performance of both cameras with and without phase mask and thereby demonstrate a significant increase in depth of field of a factor 2.5, as it was expected in the design step
Why Operationism Doesn't Go Away: Extrascientific Incentives of Social-Psychological Research
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69038/2/10.1177_004839318601600302.pd
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