La violencia en la escuela : detección y prevención de conductas violentas

En las sociedades actuales, debemos reconocer que la violencia atraviesa todas las esferas, ya sea económica, social, política y cultural. Para el presente trabajo, se reconoce que las relaciones sociales son siempre relaciones de poder, y como tales, siempre se hallan en ellas condiciones de opresión, abuso de autoridad y discriminación. La violencia se presenta como un fenómeno cotidiano en las prácticas sociales, se llega a naturalizar, actuando de un modo desprevenido y sorpresivo, no sólo frente a los atentados contra la propiedad, la agresión física y simbólica que se muestra a diario en los medios masivos de comunicación, sino también en otras formas como servicios públicos deficientes, pobreza, marginalidad, adicciones, entre otros. La propuesta de este trabajo es que los docentes puedan volver visibles las prácticas violentas a las que están sujetas las relaciones sociales de sus alumnos, dentro y fuera de la escuela, reconociendo inicialmente sus propias prácticas, como posibles portadoras de violencia.Fil: De Cara, Graciela B.. Universidad Nacional de San Jua

Effects of Contrarians in the Minority Game

We study the effects of the presence of contrarians in an agent-based model of competing populations. Contrarians are common in societies. These contrarians are agents who deliberately prefer to hold an opinion that is contrary to the prevailing idea of the commons or normal agents. Contrarians are introduced within the context of the Minority Game (MG), which is a binary model for an evolving and adaptive population of agents competing for a limited resource. Results of numerical simulations reveal that the average success rate among the agents depends non-monotonically on the fraction $a_{c}$ of contrarians. For small $a_{c}$, the contrarians systematically outperform the normal agents by avoiding the crowd effect and enhance the overall success rate. For high $a_{c}$, the anti-persistent nature of the MG is disturbed and the few normal agents outperform the contrarians. Qualitative discussion and analytic results for the small $a_{c}$ and high $a_{c}$ regimes are also presented, and the crossover behavior between the two regimes is discussed.Comment: revtex, 11 pages, 4 figure

Adaptive Boolean Networks and Minority Games with Time--Dependent Capacities

In this paper we consider a network of boolean agents that compete for a limited resource. The agents play the so called Generalized Minority Game where the capacity level is allowed to vary externally. We study the properties of such a system for different values of the mean connectivity $K$ of the network, and show that the system with K=2 shows a high degree of coordination for relatively large variations of the capacity level.Comment: 4 pages, 4 figure

Genetic Diversity and Relationships of Tlingit Moieties

The Tlingit from Southeast Alaska belong to the Northwest Coast cultural tradition, which is defined by regionally shared sociocultural practices. A distinctive feature of Tlingit social organization is the matrilineal exogamous marriage system among clans from two opposite moieties: the Raven/Crow and Eagle/Wolf. Clan and moiety membership are determined by matrilineal descent, and previous genetic studies of Northwest Coast populations have shown that there is a relationship between clan membership and genetic variation of matrilines and patrilines. To further understand this association, mitochondrial DNA (mtDNA) sequences from the Tlingit (n=154) are examined. By comparing mtDNA with moiety membership information, we explore the impact of marriage traditions among the Tlingit with their observable genetic variation. At the genetic level, the results support cultural persistence of Tlingit maternal moiety identity despite the negative impacts of European colonization. Our study additionally illustrates the relevance of data derived from Tlingit oral traditions to test hypotheses about population history on the Northwest Coast

A Youth-Leader Program in Baltimore City Recreation Centers: Lessons Learned and Applications

Peer-led interventions may be an effective means of addressing the childhood obesity epidemichowever, few studies have looked at the long-term sustainability of such programs. As part of a multilevel obesity prevention intervention, B'More Healthy Communities for Kids, 16 Baltimore college students were trained as youth-leaders (YLs) to deliver a skill-based nutrition curriculum to low-income African American children (10-14 years old). In April 2015, formative research was used to inform sustainability of the YL program in recreation centers. In-depth interviews were conducted with recreation center directors (n = 4) and the YLs (n = 16). Two focus groups were conducted with YLs (n = 7) and community youth-advocates (n = 10). Barriers to this program included difficulties with transportation, time constraints, and recruiting youth. Lessons learned indicated that improving trainings and incentives to youth were identified as essential strategies to foster continuity of the youth-led program and capacity building. High school students living close to the centers were identified as potential candidates to lead the program. Based on our findings, the initial intervention will be expanded into a sustainable model for implementation, using a train-the-trainer approach to empower community youth to be change agents of the food environment and role models.Johns Hopkins Urban Health InstituteGlobal Obesity Prevention Center at Johns HopkinsEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentOffice of the Director, National Institutes of Health [U54HD070725]646 CNPq [GDE: 249316/2013-7]Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USAUniv Tennessee, Knoxville, TN USAUniv Fed Sao Paulo, Santos, SP, BrazilDept Recreat & Pk City Baltimore, Baltimore, MD USAUniv Maryland Extens, Ellicott City, MD USAUniv Fed Sao Paulo, Santos, SP, BrazilWeb of Scienc

ICT application in teaching and learning

The purpose of this study was to investigate and assess the use of ICT in the teaching-learning process. This study assessed the senior high school students of PAU Excellencia Global Academy Foundation, Inc.’s students’ attitudes toward ICT integration and the effectiveness of ICT use in the teaching-learning process. The effectiveness of using ICT in the teaching-learning process, as well as the level of attitude toward ICT among the secondary school students participating in the research, were evaluated by the researcher using a descriptive-correlational engaging quantitative approach. As to the findings , one of the most important contributing aspects affecting a student’s success in various subjects and fields is their performance. Generous investments were justified by the firmly held belief that technology may improve student academic achievement by enabling more effective and efficient ICT integration into teaching-learning process for students

Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy

Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular disease Duchenne Muscular Dystrophy (DMD). DMD is a complicated disease, with many druggable targets at the cellular and molecular level including calcium-mediated muscle degeneration; mitochondrial dysfunction; oxidative stress; inflammation; insufficient muscle regeneration and dysregulated protein and organelle maintenance. Previous investigative therapeutics tended to isolate and focus on just one of these targets and, consequently, therapeutic activity has been limited. Nuclear erythroid 2-related factor 2 (Nrf2) is a transcription factor that upregulates many cytoprotective gene products in response to oxidants and other toxic stressors. Unlike other strategies, targeted Nrf2 activation has the potential to simultaneously modulate separate pathological features of DMD to amplify therapeutic benefits. Here, we review the literature providing theoretical context for targeting Nrf2 as a disease modifying treatment against DMD

Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favourable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated

Comparative Studies of Renin-Null Zebrafish and Mice Provide New Functional Insights

Background: The renin-angiotensin system is highly conserved across vertebrates, including zebrafish, which possess orthologous genes coding for renin-angiotensin system proteins, and specialized mural cells of the kidney arterioles, capable of synthesising and secreting renin. Methods: We generated zebrafish with CRISPR-Cas9-targeted knockout of renin ( ren −/− ) to investigate renin function in a low blood pressure environment. We used single-cell (10×) RNA sequencing analysis to compare the transcriptome profiles of renin lineage cells from mesonephric kidneys of ren −/− with ren +/+ zebrafish and with the metanephric kidneys of Ren1 c −/− and Ren1 c +/+ mice. Results: The ren −/− larvae exhibited delays in larval growth, glomerular fusion and appearance of a swim bladder, but were viable and withstood low salinity during early larval stages. Optogenetic ablation of renin-expressing cells, located at the anterior mesenteric artery of 3-day-old larvae, caused a loss of tone, due to diminished contractility. The ren −/− mesonephric kidney exhibited vacuolated cells in the proximal tubule, which were also observed in Ren1 c −/− mouse kidney. Fluorescent reporters for renin and smooth muscle actin ( Tg(ren:LifeAct-RFP; acta2:EGFP )), revealed a dramatic recruitment of renin lineage cells along the renal vasculature of adult ren −/− fish, suggesting a continued requirement for renin, in the absence of detectable angiotensin metabolites, as seen in the Ren1 YFP Ren1 c −/− mouse. Both phenotypes were rescued by alleles lacking the potential for glycosylation at exon 2, suggesting that glycosylation is not essential for normal physiological function. Conclusions: Phenotypic similarities and transcriptional variations between mouse and zebrafish renin knockouts suggests evolution of renin cell function with terrestrial survival