On the Thermodynamics of Simple Non-Isentropic Perfect Fluids in General Relativity

We examine the consistency of the thermodynamics of irrotational and non-isentropic perfect fluids complying with matter conservation by looking at the integrability conditions of the Gibbs-Duhem relation. We show that the latter is always integrable for fluids of the following types: (a) static, (b) isentropic (admits a barotropic equation of state), (c) the source of a spacetime for which $r\ge 2$, where $r$ is the dimension of the orbit of the isometry group. This consistency scheme is tested also in two large classes of known exact solutions for which $r< 2$, in general: perfect fluid Szekeres solutions (classes I and II). In none of these cases, the Gibbs-Duhem relation is integrable, in general, though specific particular cases of Szekeres class II (all complying with $r<2$) are identified for which the integrability of this relation can be achieved. We show that Szekeres class I solutions satisfy the integrability conditions only in two trivial cases, namely the spherically symmetric limiting case and the Friedman-Roberson-Walker (FRW) cosmology. Explicit forms of the state variables and equations of state linking them are given explicitly and discussed in relation to the FRW limits of the solutions. We show that fixing free parameters in these solutions by a formal identification with FRW parameters leads, in all cases examined, to unphysical temperature evolution laws, quite unrelated to those of their FRW limiting cosmologies.Comment: 29 pages, Plain.Te

Towards Combining Individual and Collaborative Work Spaces under a Unified E-Portfolio

Proceedings of: 11th International Conference on Computational Science and Applications (ICCSA 2011). Santander, Spain, June 20-23, 2011E-portfolios in learning environments have been attributed numerous benefits and their presence has been steadily increasing. And so has the variety of environments in which a student participates. Collaborative learning requires communication and resource sharing among team members. Students may participate in multiple teams throughout a long period of time, sometimes even simultaneously. Conventional eportfolios are oriented toward showcasing individual achievements, but they need to also equally reflect collaborative achievements. The approach described in this paper has the objective of offering students an e-portfolio as a local folder their personal computer containing a combined view of their individual and collaborative work spaces. The content of this folder can be synchronized with a remote server thus achieving resource sharing and publication of a clearly identified set of resources.Work partially funded by the Learn3 project, “Plan Nacional de I+D+I TIN2008- 05163/TSI”, the Consejo Social - Universidad Carlos III de Madrid, the Acción Integrada Ref. DE2009-0051, and the “Emadrid: Investigación y desarrollo de tecnologías para el e-learning en la Comunidad de Madrid” project (S2009/TIC-1650).Publicad

DooSo6: Easy Collaboration over Shared Projects

International audienceExisting tools for supporting parallel work feature some disadvantages that prevent them to be widely used. Very often they require a complex installation and creation of accounts for all group members. Users need to learn and deal with complex commands for efficiently using these collaborative tools. Some tools require users to abandon their favourite editors and impose them to use a certain co-authorship application. In this paper, we propose the DooSo6 collaboration tool that offers support for parallel work, requires no installation, no creation of accounts and that is easy to use, users being able to continue working with their favourite editors. User authentication is achieved by means of a capability-based mechanism

Towards high-speed optical quantum memories

Quantum memories, capable of controllably storing and releasing a photon, are a crucial component for quantum computers and quantum communications. So far, quantum memories have operated with bandwidths that limit data rates to MHz. Here we report the coherent storage and retrieval of sub-nanosecond low intensity light pulses with spectral bandwidths exceeding 1 GHz in cesium vapor. The novel memory interaction takes place via a far off-resonant two-photon transition in which the memory bandwidth is dynamically generated by a strong control field. This allows for an increase in data rates by a factor of almost 1000 compared to existing quantum memories. The memory works with a total efficiency of 15% and its coherence is demonstrated by directly interfering the stored and retrieved pulses. Coherence times in hot atomic vapors are on the order of microsecond - the expected storage time limit for this memory.Comment: 13 pages, 5 figure

Effect of formant frequency spacing on perceived gender in pre-pubertal children's voices

<div><p>Background</p><p>It is usually possible to identify the sex of a pre-pubertal child from their voice, despite the absence of sex differences in fundamental frequency at these ages. While it has been suggested that the overall spacing between formants (formant frequency spacing - ΔF) is a key component of the expression and perception of sex in children's voices, the effect of its continuous variation on sex and gender attribution has not yet been investigated.</p><p>Methodology/Principal findings</p><p>In the present study we manipulated voice ΔF of eight year olds (two boys and two girls) along continua covering the observed variation of this parameter in pre-pubertal voices, and assessed the effect of this variation on adult ratings of speakers' sex and gender in two separate experiments. In the first experiment (sex identification) adults were asked to categorise the voice as either male or female. The resulting identification function exhibited a gradual slope from male to female voice categories. In the second experiment (gender rating), adults rated the voices on a continuum from “masculine boy” to “feminine girl”, gradually decreasing their masculinity ratings as ΔF increased.</p><p>Conclusions/Significance</p><p>These results indicate that the role of ΔF in voice gender perception, which has been reported in adult voices, extends to pre-pubertal children's voices: variation in ΔF not only affects the perceived sex, but also the perceived masculinity or femininity of the speaker. We discuss the implications of these observations for the expression and perception of gender in children's voices given the absence of anatomical dimorphism in overall vocal tract length before puberty.</p></div

Understanding the errors of SHAPE-directed RNA structure modeling

Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms. Recent tests have shown that selective 2'-hydroxyl acylation by primer extension (SHAPE) can give near-zero error rates (0-2%) in modeling the helices of RNA secondary structure. Here, we benchmark the method using six molecules for which crystallographic data are available: tRNA(phe) and 5S rRNA from Escherichia coli, the P4-P6 domain of the Tetrahymena group I ribozyme, and ligand-bound domains from riboswitches for adenine, cyclic di-GMP, and glycine. SHAPE-directed modeling of these highly structured RNAs gave an overall false negative rate (FNR) of 17% and a false discovery rate (FDR) of 21%, with at least one helix prediction error in five of the six cases. Extensive variations of data processing, normalization, and modeling parameters did not significantly mitigate modeling errors. Only one varation, filtering out data collected with deoxyinosine triphosphate during primer extension, gave a modest improvement (FNR = 12%, and FDR = 14%). The residual structure modeling errors are explained by the insufficient information content of these RNAs' SHAPE data, as evaluated by a nonparametric bootstrapping analysis. Beyond these benchmark cases, bootstrapping suggests a low level of confidence (<50%) in the majority of helices in a previously proposed SHAPE-directed model for the HIV-1 RNA genome. Thus, SHAPE-directed RNA modeling is not always unambiguous, and helix-by-helix confidence estimates, as described herein, may be critical for interpreting results from this powerful methodology.Comment: Biochemistry, Article ASAP (Aug. 15, 2011

A new model for health care delivery

<p>Abstract</p> <p>Background</p> <p>The health care delivery system in the United States is facing cost and quality pressures that will require fundamental changes to remain viable. The optimal structures of the relationships between the hospital, medical school, and physicians have not been determined but are likely to have a large impact on the future of healthcare delivery. Because it is generally agreed that academic medical centers will play a role in the sustainability of this future system, a fundamental understanding of the relative contributions of the stakeholders is important as well as creativity in developing novel strategies to achieve a shared vision.</p> <p>Discussion</p> <p>Core competencies of each of the stakeholders (the hospital, the medical school and the physicians) must complement the others and should act synergistically. At the same time, the stakeholders should determine the common core values and should be able to make a meaningful contribution to the delivery of health care.</p> <p>Summary</p> <p>Health care needs to achieve higher quality and lower cost. Therefore, in order for physicians, medical schools, and hospitals to serve the needs of society in a gratifying way, there will need to be change. There needs to be more scientific and social advances. It is obvious that there is a real and urgent need for relationship building among the professionals whose duty it is to provide these services.</p

Development and evaluation of a tool for the assessment of footwear characteristics

<p>Abstract</p> <p>Background</p> <p>Footwear characteristics have been linked to falls in older adults and children, and the development of many musculoskeletal conditions. Due to the relationship between footwear and pathology, health professionals have a responsibility to consider footwear characteristics in the etiology and treatment of various patient presentations. In order for health professionals and researchers to accurately and efficiently critique an individual's footwear, a valid and reliable footwear assessment tool is required. The aim of this study was to develop a simple, efficient, and reliable footwear assessment tool potentially suitable for use in a range of patient populations.</p> <p>Methods</p> <p>Consideration of previously published tools, other footwear related literature, and clinical considerations of three therapists were used to assist in the development of the tool. The tool was developed to cover fit, general features, general structure, motion control properties, cushioning, and wear patterns. A total of 15 participants (who provided two pairs of shoes each) were recruited, and assessment using the scale was completed on two separate occasions (separated by 1 – 3 weeks) by a physiotherapist and a podiatrist on each participant's dominant foot. Intra-rater and inter-rater reliability were evaluated using intra-class correlation coefficients (ICCs) (model 2, 1) and the 95% limits of agreement (95% LOAs) for continuous items, and percentage agreement and kappa (κ) statistics for categorical items.</p> <p>Results</p> <p>All categorical items demonstrated high percentage agreement statistic for intra-rater (83 – 100%) and inter-rater (83 – 100%) comparisons. With the exception of last shape and objective measures used to categorise the adequacy of length, excellent intra-rater (ICC = 0.91 – 1.00) and inter-rater reliability (ICC = 0.90 – 1.00) was indicated for continuous items in the tool, including the motion control properties scale (0.91 – 0.95).</p> <p>Conclusion</p> <p>A comprehensive footwear assessment tool with good face validity has been developed to assist future research and clinical footwear assessment. Generally good reliability amongst all items indicates that the tool can be used with confidence in research and clinical settings. Further research is now required to determine the clinical validity of each item in various patient populations.</p