A Review on Smart Home Automation using Virtue of IoT

Smart home automation system in daily routine plays a starring role which helps in reducing work. Smart home automation is flattering trendy due to its various advantages. With development of Automation technology, life is getting effortless and uncomplicated in all aspects and it is intended to save the electric power and human energy besides automated systems are being favored more than manual system. With the speedy enhancement in the number of users of internet over the past decade has made Internet an essential part of life. Nowadays IoT is the most recent and promising internet technology. This paper describes the literature survey of existing system. We will perceive a review of the technology used to design this system. Comparisons of different system technology are studied in this paper.

Threshold selection in gene co-expression networks using spectral graph theory techniques

Abstract Background Gene co-expression networks are often constructed by computing some measure of similarity between expression levels of gene transcripts and subsequently applying a high-pass filter to remove all but the most likely biologically-significant relationships. The selection of this expression threshold necessarily has a significant effect on any conclusions derived from the resulting network. Many approaches have been taken to choose an appropriate threshold, among them computing levels of statistical significance, accepting only the top one percent of relationships, and selecting an arbitrary expression cutoff. Results We apply spectral graph theory methods to develop a systematic method for threshold selection. Eigenvalues and eigenvectors are computed for a transformation of the adjacency matrix of the network constructed at various threshold values. From these, we use a basic spectral clustering method to examine the set of gene-gene relationships and select a threshold dependent upon the community structure of the data. This approach is applied to two well-studied microarray data sets from Homo sapiens and Saccharomyces cerevisiae. Conclusion This method presents a systematic, data-based alternative to using more artificial cutoff values and results in a more conservative approach to threshold selection than some other popular techniques such as retaining only statistically-significant relationships or setting a cutoff to include a percentage of the highest correlations

Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5

ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothesis, we generated heterozygous (Atad5+/m) mice that were haploinsuffficient for Atad5. Atad5+/m mice displayed high levels of genomic instability in vivo, and Atad5+/m mouse embryonic fibroblasts (MEFs) exhibited molecular defects in PCNA deubiquitination in response to DNA damage, as well as DNA damage hypersensitivity and high levels of genomic instability, apoptosis, and aneuploidy. Importantly, 90% of haploinsufficient Atad5+/m mice developed tumors, including sarcomas, carcinomas, and adenocarcinomas, between 11 and 20 months of age. High levels of genomic alterations were evident in tumors that arose in the Atad5+/m mice. Consistent with a role for Atad5 in suppressing tumorigenesis, we also identified somatic mutations of ATAD5 in 4.6% of sporadic human endometrial tumors, including two nonsense mutations that resulted in loss of proper ATAD5 function. Taken together, our findings indicate that loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis

A simple method for deprotection of <i>tert</i>-butyldimethylsilyl ethers by using stannous chloride under microwave irradiation

322-324A facile regeneration of hydroxy compounds from their tert-butyldimethylsilyl ethers in presence of stannous chloride under solvent free conditions using domestic microwave oven has been performed efficiently in a short period (5-6 min). The conversion using stannous chloride in ethanol or water for comparison of the efficiency has been described. The generality of the transformation has been confirmed by several examples

Selective cleavage of 2,3-O-isopropylidene group: a case of anchimeric assistance from O-glycoside

Alkyl 2,3-O-isopropylidene-5-O-methoxymethylfuranoside derivatives undergo selective cleavage of the 2,3-O-isopro-pylidene group, if oriented cis to the O-glycoside, in the presence of trifluoroacetic acid. Otherwise, the cleavage of the 5-O-methoxy-methyl group is favoured over the 2,3-O-isopropylidene group

A general method for the synthesis of 11-Deoxyanthracyclinones

A general method for the synthesis of 11-deoxyanthracyclinones is described

Comparison of threshold selection methods for microarray gene co-expression matrices.

ABSTRACT: BACKGROUND: Network and clustering analyses of microarray co-expression correlation data often require application of a threshold to discard small correlations, thus reducing computational demands and decreasing the number of uninformative correlations. This study investigated threshold selection in the context of combinatorial network analysis of transcriptome data. FINDINGS: Six conceptually diverse methods - based on number of maximal cliques, correlation of control spots with expressed genes, top 1% of correlations, spectral graph clustering, Bonferroni correction of p-values, and statistical power - were used to estimate a correlation threshold for three time-series microarray datasets. The validity of thresholds was tested by comparison to thresholds derived from Gene Ontology information. Stability and reliability of the best methods were evaluated with block bootstrapping.Two threshold methods, number of maximal cliques and spectral graph, used information in the correlation matrix structure and performed well in terms of stability. Comparison to Gene Ontology found thresholds from number of maximal cliques extracted from a co-expression matrix were the most biologically valid. Approaches to improve both methods were suggested. CONCLUSION: Threshold selection approaches based on network structure of gene relationships gave thresholds with greater relevance to curated biological relationships than approaches based on statistical pair-wise relationships

Microwave assisted solvent-free synthesis of dihydropyrimidinones by Biginelli reaction over Si-MCM-41 supported FeCl<SUB>3</SUB> catalyst

Among the Si-MCM-41 or montmorillonite K 10 clay supported ZnCl2, AlCl3, GaCl3, InCl3 and FeCl3 catalysts, FeCl3/Si-MCM-41 shows best performance for the microwave-assisted synthesis of dihydropyrimidinones by the Biginelli reaction involving multicomponent condensation of aromatic aldehyde, ethyl acetoacetate and urea in the absence of any solvent. It is a promising catalyst for the microwave-assisted reaction providing high product yield in a short period (3.0-5.0 min)