431 research outputs found

    Abraham, der Ausgezeichnete: die Loyalitätsprobe

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    Aschenputtel: Aus der Asche inden Glanz - eine weibliche Karriere

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    Aschenputtel agiert selbstbestimmt und undercover. Sie legt angesichts der feindlichen Übermacht die Karten nicht auf den Tisch. Sie bleibt nicht verzagt hinterm Ofen, sondern geht in voller Pracht und als kluge Verführerin zu den königlichen Festen. Sie ist angesichts des häuslichen Machtgefälles äußerlich gefügig, formuliert aber wie in Bertolt Brechts Parabel von den Maßnahmen gegen die Gewalt ein freies inneres Nein

    International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe

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    In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors’ experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible

    (2015) Reflective Supervision as a Key Support for Counselors

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    Reflective supervision is a protected time and space for a counselor to consider his or her work from multiple perspectives with a trusted mental health professional (Shahmoon-Shanok, 2009). The authors present reflective supervision as an important component of on-going counselor practice that is separate from clinical supervision provided during counselor training. Theories of clinical and reflective supervision are discussed as they relate to the development of reflective practice for counselors. Reflective supervision is differentiated from clinical and administrative supervision as well as from periodic case consultation. The authors discuss how reflective supervision for counselors is a foundational component of their early childhood mental health consultation program, and they delineate challenges and considerations for implementing reflective supervision into a program or practice

    Antiepileptic drugs’ tolerability and safety – a systematic review and meta-analysis of adverse effects in dogs

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    <p>Various anti-epileptic drugs (AEDs) are used for the management of idiopathic epilepsy (IE) in dogs. Their safety profile is an important consideration for regulatory bodies, owners and prescribing clinicians. However, information on their adverse effects still remains limited with most of it derived from non-blinded non-randomized uncontrolled trials and case reports.</p><p><span>This poster won third place, which was presented at the Veterinary Evidence Today conference, Edinburgh November 1-3, 2016. </span></p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /

    Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy in a Refractory Malignant Solitary Fibrous Tumor of the Pleura

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    Solitary fibrous tumor of the pleura is a rare and usually benign primary neoplasm arising from mesenchymal cells of the submesothelial tissue. We present here the case of a patient diagnosed with CD34-positive advanced malignant solitary fibrous tumor of the pleura whose disease failed to respond to combination cytotoxic chemotherapy agents, but demonstrated a prompt near-complete response to checkpoint blockade treatment using the anti-programmed death (PD)-1 monoclonal antibody pembrolizumab, based on tumor molecular profiling revealing tumoral expression positivity for both programmed death-ligand 1 (PD-L1) and PD-1. The patient experienced minimal adverse effects from the treatment with durable favorable response lasting up to cycle 26
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