His story/her story: A dialogue about including men and masculinities in the women’s studies curriculum

The article discusses the issue of inclusion of men and masculinities in the Women\u27s Studies curriculum. Women\u27s Studies programs were started to compensate for the male domination in the academics. Women\u27s Studies presented a platform where scholarship for women was produced and taken seriously, female students and faculty could find their say or voice, and theoretical investigations required for the advancement of the aims of the women\u27s movement could take place. If the academy as a whole does not sufficiently integrate Women\u27s Studies into the curriculum, integrating Men\u27s Studies into Women\u27s Studies might end up further marginalizing Women\u27s Studies by decreasing the number of classroom hours students spend engaging women\u27s lives and feminist scholarship. Such an integration would presents an another form of male privilege, with men manipulating their way into the only branch of scholarship that has consistently focused on women. On a ground level, feminist scholars are apprehensive that a move from a Women\u27s Studies program to a Gender Studies program will reduce the political aspect of women\u27s programs

'I act this way because why?' Prior knowledges, teaching for change, imagining new masculinities

This article begins by outlining some of the prior knowledges brought by undergraduate students to an introduction to gender studies class in the Women's and Gender Studies Department at the University of the Western Cape, South Africa. I show that, at the beginning of the course, students clearly understand gender to refer to women and femininity, imagining femininity (but not masculinity) to be responsive to social change. I suggest that, in the face of these prior knowledges, it is important to focus on masculinity as performance, as a cultural artefact and one that is deeply harmful to South African men. Student experiences of this teaching and learning suggest that it offers possibilities for imagining men as allies and beneficiaries - rather than enemies - in the struggle for gender equity

Candida glabrata : a review of its features and resistance

Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections. Once believed to be non-pathogenic, Candida glabrata was rapidly blamable for many human diseases. Year after year, these pathological circumstances are more recurrent and problematic to treat, especially when patients reveal any level of immunosuppression. These difficulties arise from the capacity of C. glabrata to form biofilms and also from its high resistance to traditional antifungal therapies. Thus, this review intends to present an excerpt of the biology, epidemiology, and pathology of C. glabrata, and detail an approach to its resistance mechanisms based on studies carried out up to the present.The authors are grateful to strategic project PTDC/SAU-MIC/119069/2010 for the financial support to the research center and for Celia F. Rodrigues' grant

Contribution of CgPDR1-Regulated Genes in Enhanced Virulence of Azole-Resistant Candida glabrata

In Candida glabrata, the transcription factor CgPdr1 is involved in resistance to azole antifungals via upregulation of ATP binding cassette (ABC)-transporter genes including at least CgCDR1, CgCDR2 and CgSNQ2. A high diversity of GOF (gain-of-function) mutations in CgPDR1 exists for the upregulation of ABC-transporters. These mutations enhance C. glabrata virulence in animal models, thus indicating that CgPDR1 might regulate the expression of yet unidentified virulence factors. We hypothesized that CgPdr1-dependent virulence factor(s) should be commonly regulated by all GOF mutations in CgPDR1. As deduced from transcript profiling with microarrays, a high number of genes (up to 385) were differentially regulated by a selected number (7) of GOF mutations expressed in the same genetic background. Surprisingly, the transcriptional profiles resulting from expression of GOF mutations showed minimal overlap in co-regulated genes. Only two genes, CgCDR1 and PUP1 (for PDR1 upregulated and encoding a mitochondrial protein), were commonly upregulated by all tested GOFs. While both genes mediated azole resistance, although to different extents, their deletions in an azole-resistant isolate led to a reduction of virulence and decreased tissue burden as compared to clinical parents. As expected from their role in C. glabrata virulence, the two genes were expressed as well in vitro and in vivo. The individual overexpression of these two genes in a CgPDR1-independent manner could partially restore phenotypes obtained in clinical isolates. These data therefore demonstrate that at least these two CgPDR1-dependent and -upregulated genes contribute to the enhanced virulence of C. glabrata that acquired azole resistance