A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways).

Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological deficits are limited. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following cardiac arrest with associated global cerebral ischemia. The search was limited to investigational therapies that were utilized to treat global cerebral ischemia associated with cardiac arrest. In this review we discuss potential mechanisms of neurologic protection following cardiac arrest including actions of several medical gases such as xenon, argon, and nitric oxide. The 3 included mechanisms are: 1. Modulation of neuronal cell death; 2. Alteration of oxygen free radicals; and 3. Improving cerebral hemodynamics. Only a few approaches have been evaluated in limited fashion in cardiac arrest patients and results show inconclusive neuroprotective effects. Future research focusing on combined neuroprotective strategies that target multiple pathways are compelling in the setting of global brain ischemia resulting from cardiac arrest

ERTS and aircraft multispectral scanner digital data users manual

There are no author-identified significant results in this report

Cosmology and Astrophysics from Relaxed Galaxy Clusters II: Cosmological Constraints

We present cosmological constraints from measurements of the gas mass fraction, $f_{gas}$, for massive, dynamically relaxed galaxy clusters. Our data set consists of Chandra observations of 40 such clusters, identified in a comprehensive search of the Chandra archive, as well as high-quality weak gravitational lensing data for a subset of these clusters. Incorporating a robust gravitational lensing calibration of the X-ray mass estimates, and restricting our measurements to the most self-similar and accurately measured regions of clusters, significantly reduces systematic uncertainties compared to previous work. Our data for the first time constrain the intrinsic scatter in $f_{gas}$, $(7.4\pm2.3)$% in a spherical shell at radii 0.8-1.2 $r_{2500}$, consistent with the expected variation in gas depletion and non-thermal pressure for relaxed clusters. From the lowest-redshift data in our sample we obtain a constraint on a combination of the Hubble parameter and cosmic baryon fraction, $h^{3/2}\Omega_b/\Omega_m=0.089\pm0.012$, that is insensitive to the nature of dark energy. Combined with standard priors on $h$ and $\Omega_b h^2$, this provides a tight constraint on the cosmic matter density, $\Omega_m=0.27\pm0.04$, which is similarly insensitive to dark energy. Using the entire cluster sample, extending to $z>1$, we obtain consistent results for $\Omega_m$ and interesting constraints on dark energy: $\Omega_\Lambda=0.65^{+0.17}_{-0.22}$ for non-flat $\Lambda$CDM models, and $w=-0.98\pm0.26$ for flat constant-$w$ models. Our results are both competitive and consistent with those from recent CMB, SNIa and BAO data. We present constraints on models of evolving dark energy from the combination of $f_{gas}$ data with these external data sets, and comment on the possibilities for improved $f_{gas}$ constraints using current and next-generation X-ray observatories and lensing data. (Abridged)Comment: 25 pages, 14 figures, 8 tables. Accepted by MNRAS. Code and data can be downloaded from http://www.slac.stanford.edu/~amantz/work/fgas14/ . v2: minor fix to table 1, updated bibliograph

Cosmic string induced sheet like baryon inhomogeneities at quark-hadron transition

Cosmic strings moving through matter produce wakes where density is higher than the background density. We investigate the effects of such wakes occurring at the time of a first order quark-hadron transition in the early universe and show that they can lead to separation of quark-gluon plasma phase in the wake region, while the region outside the wake converts to the hadronic phase. Moving interfaces then trap large baryon densities in sheet like regions which can extend across the entire horizon. Typical separation between such sheets, at formation, is of the order of a km. Regions of baryon inhomogeneity of this nature, i.e. having a planar geometry, and separated by such large distance scales, appear to be well suited for the recent models of inhomogeneous nucleosynthesis to reconcile with the large baryon to photon ratio implied by the recent measurements of the cosmic microwave background power spectrum.Comment: 8 pages, 3 figure

Peaks above the Harrison-Zel'dovich spectrum due to the Quark-Gluon to Hadron Transition

The quark-gluon to hadron transition affects the evolution of cosmological perturbations. If the phase transition is first order, the sound speed vanishes during the transition, and density perturbations fall freely. This distorts the primordial Harrison-Zel'dovich spectrum of density fluctuations below the Hubble scale at the transition. Peaks are produced, which grow at most linearly in wavenumber, both for the hadron-photon-lepton fluid and for cold dark matter. For cold dark matter which is kinetically decoupled well before the QCD transition clumps of masses below $10^{-10} M_\odot$ are produced.Comment: Extended version, including evolution of density perturbations for a bag model and for a lattice QCD fit (3 new figures). Spectrum for bag model (old figure) is available in astro-ph/9611186. 9 pages RevTeX, uses epsf.sty, 3 PS figure

Large Scale Inhomogeneities from the QCD Phase Transition

We examine the first-order cosmological QCD phase transition for a large class of parameter values, previously considered unlikely. We find that the hadron bubbles can nucleate at very large distance scales, they can grow as detonations as well as deflagrations, and that the phase transition may be completed without reheating to the critical temperature. For a subset of the parameter values studied, the inhomogeneities generated at the QCD phase transition might have a noticeable effect on nucleosynthesis.Comment: 15 LaTeX pages + 6 PostScript figures appended at the end of the file, HU-TFT-94-1

X-ray Bright Active Galactic Nuclei in Massive Galaxy Clusters II: The Fraction of Galaxies Hosting Active Nuclei

We present a measurement of the fraction of cluster galaxies hosting X-ray bright Active Galactic Nuclei (AGN) as a function of clustercentric distance scaled in units of $r_{500}$. Our analysis employs high quality Chandra X-ray and Subaru optical imaging for 42 massive X-ray selected galaxy cluster fields spanning the redshift range of $0.2 < z < 0.7$. In total, our study involves 176 AGN with bright ($R <23$) optical counterparts above a $0.5-8.0$ keV flux limit of $10^{-14} \rm{erg} \ \rm{cm}^{-2} \ \rm{s}^{-1}$. When excluding central dominant galaxies from the calculation, we measure a cluster-galaxy AGN fraction in the central regions of the clusters that is $\sim 3$ times lower that the field value. This fraction increases with clustercentric distance before becoming consistent with the field at $\sim 2.5 r_{500}$. Our data exhibit similar radial trends to those observed for star formation and optically selected AGN in cluster member galaxies, both of which are also suppressed near cluster centers to a comparable extent. These results strongly support the idea that X-ray AGN activity and strong star formation are linked through their common dependence on available reservoirs of cold gas.Comment: 9 Pages, 4 Figures, accepted for publication in MNRAS, please contact Steven Ehlert ([email protected]) with any querie