Status of major southern California marine sport fish species with management recommendations, based on analyses of catch and size composition data collected on board commercial passenger fishing vessels from 1985 through 1987

This report on the status of major southern California marine sport fish species, together with management recommendations, is based on analyses of catch and size composition data, which were collected on board Commercial Passenger Fishing Vessels (CPFV) from 1985 through 1987. The project was designed to determine the status of those fishes that support the CPFV industry, and to make management recommendations when deemed necessary. We collected and analyzed data based on random, stratified, on-board sampling of weekday (excluding holidays), open CPFV's on a year-round basis. We sampled 1/2-day, 3/4-day, and full-day type trips at a level of 5%. The survey area extended from below the United States-Mexican border to Point Arguello. Catch estimates were extrapolated to include weekday as well as weekend and holiday, open and chartered CPFV's. We sampled 736 CPFV trips in 1985, 650 in 1986, and 631 in 1987. We encountered 180 species of fishes, including 49 species of rockfishes. We performed detailed analyses on 14 non-rockfish species and 12 rockfish species, as well as all fishes as a group and all rockfishes as a group. We found a moderate increase in total catch of combined fish species between this study and one in the mid-1970's, due primarily to sizeable increases in catches of Pacific mackerel, kelp bass, barred sand bass, and barracuda. However, we also found that there has been more than a 50% decline in the CPFV rockfish catches, due primarily to substantial decreases in catches of bocaccio, chilipepper, and olive rockfish. We have recommended that the current 15-rockfish bag limit regulation be reduced to a 10-rockfish bag limit, and that additional and equitable conservation measures also be implemented on the commercial rockfish fishery. (385pp.

Rheumatoid arthritis

Immune-mediated inflammatory disorders include a clinically diverse group of conditions that share similar pathogenic mechanisms. Conditions such as rheumatoid arthritis (RA), psoriasis, spondyloarthropathy, inflammatory bowel disease and connective-tissue disease are characterised by immune dysregulation and chronic inflammation. This review will focus on immunopathogenic mechanisms, aspects of early disease, co-morbidity and therapy in RA.Keywords: immune, inflammatory, rheumatoid arthritis, therap

Pre-operational baseline studies of selected nearshore marine biota at the Diablo Canyon power plant site: 1979-1982

This is the final report of the California Department of Fish and Games intertidal and subtidal surveys of plants and animals in the vicinity of the Diablo Canyon Power Plant. These studies cover the period from 1979 through 1982. Our previous report (Gotshall, et al. 1984) covered the period from 1973 through 1978. The report includes abundances and statistical analyses of comparisons of abundances between years and study areas for selected intertidal and subtidal plants and animals. A total of 556 random subtidal stations, 540 intertidal stations and 67 permanent abalone transects were completed during this report period. Trends in abundances of most species observed during our 1973 through 1978 studies continued, i.e. the population of giant red sea urchins remained at a very low level, bull kelp Nereocystis leutkeana densities continued to decline in Diablo Cove and North Control. These two trends are probably due to the effects of continued sea otter foraging in the study area. Our observations of the presence or absence of fishes at subtidal 30m stations indicate a continued decline in the abundances of lingcod, Ophiodon elongatus and a decline in the abundance of blue rockfish since the 1973 through 1978 study period. A new study was begun during this study period, the use of baited stations to obtain relative abundance indices for those species of fishes attracted to the bait. Black-and-yellow rockfish were the most frequently observed fishes at Diablo Cove stations, while blue rockfish were the most frequently observed fish at North control baited stations. (Document has 393 pages

Bacterial Actin Assembly Requires Toca-1 to Relieve N-WASP Autoinhibition

SummaryActin polymerization in the mammalian cytosol can be locally activated by mechanisms that relieve the autoinhibited state of N-WASP, an initiator of actin assembly, a process that also requires the protein Toca-1. Several pathogenic bacteria, including Shigella, exploit this host feature to infect and disseminate efficiently. The Shigella outer membrane protein IcsA recruits N-WASP, which upon activation at the bacterial surface mediates localized actin polymerization. The molecular role of Toca-1 in N-WASP activation during physiological or pathological actin assembly processes in intact mammalian cells remains unclear. We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP from a closed inactive conformation to an open active one. While N-WASP recruitment is dependent on IcsA, Toca-1 recruitment is instead mediated by S. flexneri type III secretion effectors. Thus, S. flexneri independently hijacks two nodes of the N-WASP actin assembly pathway to initiate localized actin tail assembly

Determinants of Adoption of Improved Crossbred Cattles: A Case Study of Suba and Laikipia Districts, Kenya

Recognizing that more than 10% of the Kenyan GDP and 50% of agricultural GDP are comprised of sales within the livestock subsector; the purpose of this research is to identify the determinants of adoption of improved crossbred cattle in rural Kenya. This research has important implications for increasing the dairy subsectors’ productivity, improving nutrient intake within rural Kenya and motivating higher rates of foreign direct investment in a sustainable, beneficial sector. We used a publicly available (www.ifpri.org) dataset called "Land Tenure, Agricultural Productivity and the Environment, 2001." A logistical regression analysis is employed to answer our research questions. The results showed that: family members education, having an extra job in addition to farming, and exposure to external market forces (was the farmer a local, or immigrant) all greatly contributed to the likelihood of adoption. This research aims to gnaw away at the ambiguity and lack of research associated with the Kenyan dairy sub-sector and aims to facilitate greater understanding and investment in the sector. Keywords: Adoption, Logistic regression, Kenya, Crossbreed cattl

Hepatitis B and C virus infections and liver function in AIDS patients at Chris Hani Baragwanath Hospital, Johannesburg

Background: Impaired liver function tests and co-infection with hepatitis viruses in AIDS patients are common in western countries.Objective: To assess liver function and prevalence of co-infection with hepatitis B and hepatitis C viruses in AIDS patients at Chris Hani Baragwanath Hospital.Design: A prospective study.Setting: Chris Hani Baragwanath Hospital, Johannesburg, South Africa.Patients: One hundred consecutive patients with AIDS admitted to Chris Hani Baragwanath Hospital.Results: There were 52 males and 48 females aged 16 to 54 years (mean + SD: 34.6 + 7.5 years). The results of laboratory test were as follows: LFTs: bilirubin 11.8 (+15.6) ìmol/ l; AST: 79.6 (±116.6) iu/L; alkaline phosphatase: 204.3 (±237.4) iì/L; albumin: 23.9 (±6.2) g/l; CD4+ Iymphocytes: 141.5 (±168.6) ìl; CD8+: 666.9 (±618.3) ìl; HBV - HbsAg: 6 (6%); HbsAg + eAg: 3 (3%); previous disease (Anti HBs and/or anti HBc): 35%, HCV: 1(1%).Conclusion: Liver function tests were impaired in the majority of patients with AIDS (93%) in our setting. Evidence of previous and present HBV infection was present in 41%. This is different from what is observed in western countries (90-95%). The results also suggest that patients here acquired HBV infection while still immuno competent. HCV infectionwas rare

Hepatitis C infection at a tertiary hospital in South Africa: Clinical presentation, non-invasive assessment of liver fibrosis, and response to therapy

Background. Hepatitis C is a viral infection that leads to chronic liver disease, resulting in significant morbidity and mortality.Objectives. To describe the demographic characteristics and clinical presentation of patients with chronic hepatitis C infection. The aspartate aminotransferase-to-platelet ratio index (APRI) and the fibrosis index based on 4 factors (FIB-4) were assessed for prediction of liver fibrosis.Methods. We retrospectively reviewed 87 records of patients who presented to the liver clinic at Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa, from January 2007 to December 2016. Patients’ records were reviewed and analysed using SPSS statistical software version 24. Convenience sampling was used.Results. The patients’ mean (standard deviation (SD)) age was 52.6 (12.3) years. Fifty-four percent were female. Hepatitis C virus genotype 5 was exclusively found in blacks (p<0.001), constituting 60.3% of infections in this ethnic group and 48.7% in the cohort, followed by genotype 1 (21.8%), genotype 3 (15.4%), genotype 4 (10.3%) and mixed-genotype infections (3.8%). Genotype 5 patients were older (mean (SD) age 56.7 (9.8) years) than genotype 1 (46.3 (11.4) years) and genotype 3 (42 (9.8) years) (p=0.002 and p<0.001, respectively). The receiver operating characteristic curve for METAVIR F0 v. APRI (cut-off <0.7) showed a moderate correlation, with an area under the curve (AUC) of 0.349 (p=0.002), sensitivity of 78.8%, specificity of 70.6% and a negative predictive value (NPV) of 63.2%. METAVIR F4 v. APRI (cut-off ≥1.5) showed an AUC of 0.881 (p=0.001) with sensitivity of 85.7%, specificity of 93% and a positive predictive value (PPV) of 67%. METAVIR F0 v. FIB-4 (cut-off <1.45) showed a moderate correlation, with an AUC of 0.332 (p=0.021), sensitivity of 78.3%, specificity of 53.8% and an NPV of 73.7%. METAVIR F4 v. FIB-4 (cut-off >3.25) had a strong correlation, with an AUC of 0.952 (p<0.001), sensitivity of 63.6%, specificity of 100% and a PPV of 100%. Early virological response (EVR) was found to predict sustained virological response (SVR) to therapy (odds ratio 27.8; 95% confidence interval 2.8 - 274.3; p=0.004).Conclusions. Compared with other genotypes, genotype 5 was predominant in our cohort, particularly in older age groups. Moreover, APRI and FIB-4 scores correlated significantly with advanced fibrosis in HCV patients. Finally, EVR during therapy was found to determine SVR

Building a developmental public service in Africa : an assessment of five decades of effort

The objective of this article is to provide an overview of the underlying causes behind Africa’s current condition of public services. It is necessary to understand, diagnose, and place in a proper perspective any prescriptions meant to address the specific problems that characterize Africa’s public services. This is with the view to making Africa’s public services contribute effectively to building capable democratic and developmental states, which many of the papers presented during the 30th AAPAM Roundtable Conference, held in October, 2008 in Accra, Ghana, dealt with