Buckling Analysis of Anti-Symmetric Cross-Ply Laminated Composite Plates under Different Boundary Conditions

The buckling analysis of anti-symmetric cross-ply laminated composite plates under different boundary conditions is examined by using a refined higher order exponential shear deformation theory.Проведено аналіз втрати стійкості антисиметрично перехресно армованої шаруватої композитної пластинки при різних граничних умовах в рамках уточненої теорії вищого порядку, що враховує зсувні деформації

SOCS-1 1478 CA/del gene polymorphism affects survival in colorectal carcinoma

Aims and Background: Suppressor of cytokine signaling 1 (SOCS1) is a prototype molecule of the SOCS family. Alterations in the SOCS1 expression have been reported in human cancers and some studies suggest that SOCS1 might act as a tumor suppressor in carcinogenesis. In the present study, we aimed to evaluate the association of SOCS1 promoter -1478CA/del gene polymorphism detected in DNA isolated from the tissues of patients with colorectal cancer (CRC) for histopathological characteristics and survival. Patients and Methods: For the study, we retrospectively enrolled 53 patients with resected colon due to CRC and 23 control subjects with no systemic illness. SOCS1- 1478CA/del gene polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism methodology. These results were evaluated in relation to histopathological features and survival results and analyzed statistically. A P value equal to or less than 0.05 was considered significant. Results: Neither control subjects nor the CRC group showed a significant association with SOCS1 -1478CA/del gene polymorphism (p = 0.248). SOCS1 -1478CA/del gene polymorphism was not significantly associated with histopathological features either. However, in the overall survival (OS) analysis, those patients with the del/del allele were found to have a 3.9-fold greater risk of mortality compared to those with CA/CA allele (p = 0.05). Progression-free survival (PFS) was also significantly different in such patients (p = 0.05). Conclusion: The present study examining the association of SOCS1 -1478CA/del gene polymorphism with CRC showed that CRC patients with del/del allele had both significantly shorter PFS and OS versus those with CA/CA or CA/del allele

The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia

Background: Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection. Aims: In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM. Materials and Methods: Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both). Results: According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.Conclusion: The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors

Between Byzantium and Jerusalem? The principality of Antioch, Renaud of Châtillon, and the penance of Mamistra in 1158

In the summer of 1158, Manuel I Komnenos, emperor of Byzantium, brought a large force into Cilicia to quell Armenian resistance and to seek retribution for an attack launched on the Byzantine island of Cyprus by Renaud of Châtillon, prince of Antioch. In haste, Renaud came to the city of Mamistra, and performed a humiliating penance before agreeing to imperial overlordship. Historians have long conceived of this act as one forced on Renaud by Manuel and King Baldwin III of Jerusalem, and as marking the creation of a political condominium, which divided Antioch between these two rulers. This article seeks to challenge the established opinion by drawing attention to the diplomatic skill demonstrated by the Antiochenes, and the independence with which they pursued and secured close and favourable ties to Byzantium