Case Report - Primary biliary tuberculosis - an unusual case

A 25-year-old woman presented with intermittent pain in the right hypochondrium, and low-grade fever of six months duration. A diagnosis of acute on chronic cholecystitis was made. On exploratory laparotomy, the gall bladder was filled with pus and stones. A diagnosis of tuberculosis was made postoperatively by sending the pus for microbiological, and gall bladder for histopathological examination. The pus grew acid-fast bacilli. On culture, the pus and the stone grew mycobacterium tuberculosis. Anti-tubercular therapy resulted in complete recovery

A 2a adenosine receptor: Structures, modeling, and medicinal chemistry

Many selective agonists and antagonists of the A 2A adenosine receptor (AR) have been reported, while allosteric modulators specific for this receptor are still needed. Many heterocyclic chemotypes have been discovered as A 2A AR antagonists, while most of the known AR agonists are nucleosides or 3,5-dicyanopyridine derivatives. A few A 2A AR ligands have been in clinical trials as antihypertensives, anti-inflammatory or diagnostic compounds (agonists), and as drugs for treating Parkinson’s disease and cancer (antagonists). The A 2A AR has become one of the most widely investigated G protein-coupled receptor (GPCR) structures using X-ray crystallography and also biophysical techniques such as NMR. Thus, the design of agonists, antagonists, and allosteric modulators has become structure-based, with numerous examples of in silico approaches, including virtual ligand screening (VLS), leading to the discovery of both novel agonists and antagonists