434 research outputs found
Airborne occupational exposures and the risk of developing respiratory symptoms and airway obstruction in the Lifelines Cohort Study
OBJECTIVES: To date, only a few studies have investigated the associations between occupational exposures and respiratory outcomes longitudinally in the general population. We investigated the associations between occupational exposures and the development of respiratory symptoms and airway obstruction in the Lifelines Cohort Study. METHODS: We included 35 739 occupationally active subjects with data on chronic cough, chronic phlegm, chronic bronchitis or airway obstruction at baseline and approximately 4.5 years follow-up. Exposures to biological dust, mineral dust, gases/fumes, pesticides, solvents and metals in the current job at baseline were estimated with the ALOHA+job-exposure matrix (JEM). Airway obstruction was defined as FEV1/FVC below the lower limit of normal. Logistic regression analysis adjusted for baseline covariates was used to investigate the associations. RESULTS: At follow-up, 1888 (6.0%), 1495 (4.7%), 710 (2.5%) and 508 (4.5%) subjects had developed chronic cough, chronic phlegm, chronic bronchitis and airway obstruction, respectively. High exposure to biological dust was associated with a higher odds to develop chronic cough and chronic bronchitis. High exposure to pesticides was associated with a higher odds for the development of all respiratory symptoms and airway obstruction. In the multiple exposures analyses, only the association between pesticides exposure and respiratory symptoms remained. CONCLUSIONS: Subjects exposed to high pesticides had a higher odds to develop respiratory symptoms on average 4.5 years later. Control measures should be taken to reduce pesticides exposure among the working population to prevent respiratory symptoms and airway obstruction
Workplace Interventions to Prevent Disability from Both the Scientific and Practice Perspectives: A Comparison of Scientific Literature, Grey Literature and Stakeholder Observations
Purpose The significant individual and societal burden of work disability could be reduced if supportive workplace strategies could be added to evidence-based clinical treatment and rehabilitation to improve return-to-work (RTW) and other disability outcomes. The goal of this article is to summarize existing research on workplace interventions to prevent disability, relate these to employer disability management practices, and recommend future research priorities. Methods The authors participated in a year-long collaboration that ultimately led to an invited 3-day conference, Improving Research of Employer Practices to Prevent Disability, held October 14?16, 2015, in Hopkinton, Massachusetts, USA. The collaboration included a topical review of the literature, group conference calls to identify key areas and challenges, drafting of initial documents, review of industry publications, and a conference presentation that included feedback from peer researchers and a question/answer session with an expert panel with direct employer experience. Results Evidence from randomized trials and other research designs has shown general support for job modification, RTW coordination, and organizational support, but evidence is still lacking for interventions at a more granular level. Grey literature reports focused mainly on job re-design and work organization. Panel feedback focused on organizational readiness and the beliefs and values of senior managers as critical factors in facilitating changes to disability management practices. While the scientific literature is focused on facilitating improved coping and reducing discomforts for individual workers, the employer-directed grey literature is focused on making group-level changes to policies and procedures. Conclusions Future research might better target employer practices by tying interventions to positive workplace influences and determinants, by developing more participatory interventions and research designs, and by designing interventions that address factors of organizational change. Electronic supplementary material The online version of this article (doi:10.1007/s10926-016-9664-z) contains supplementary material, which is available to authorized users
The whole and its parts : why and how to disentangle plant communities and synusiae in vegetation classification
Most plant communities consist of different structural and ecological subsets, ranging from cryptogams to different tree layers. The completeness and approach with which these subsets are sampled have implications for vegetation classification. Nonâvascular plants are often omitted or sometimes treated separately, referring to their assemblages as âsynusiaeâ (e.g. epiphytes on bark, saxicolous species on rocks). The distinction of complete plant communities (phytocoenoses or holocoenoses) from their parts (synusiae or merocoenoses) is crucial to avoid logical problems and inconsistencies of the resulting classification systems. We here describe theoretical differences between the phytocoenosis as a whole and its parts, and outline consequences of this distinction for practise and terminology in vegetation classification. To implement a clearer separation, we call for modifications of the International Code of Phytosociological Nomenclature and the EuroVegChecklist. We believe that these steps will make vegetation classification systems better applicable and raise the recognition of the importance of nonâvascular plants in the vegetation as well as their interplay with vascular plants
Associations of Genetic Factors, Educational Attainment, and Their Interaction With Kidney Function Outcomes
Both genetic predisposition and low educational attainment (EA) are associated with higher risk of chronic kidney disease. We examined the interaction of EA and genetic risk in kidney function outcomes. We included 3,597 participants from the Prevention of Renal and Vascular End-Stage Disease Cohort Study, a longitudinal study in a community-based sample from Groningen, the Netherlands (median follow-up, 11 years; 1997-2012). Kidney function was approximated by obtaining estimated glomerular filtration rate (eGFR) from serum creatinine and cystatin C. Individual longitudinal linear eGFR trajectories were derived from linear mixed models. Genotype data on 63 single-nucleotide polymorphisms, with known associations with eGFR, were used to calculate an allele-weighted genetic score (WGS). EA was categorized into high, medium, and low. In ordinary least squares analysis, higher WGS and lower EA showed additive effects on reduced baseline eGFR; the interaction term was nonsignificant. In analysis of eGFR decline, the significant interaction term suggested amplification of genetic risk by low EA. Adjustment for known renal risk factors did not affect our results. This study presents the first evidence of gene-environment interaction between EA and a WGS for eGFR decline and provides population-level insights into the mechanisms underlying socioeconomic disparities in chronic kidney disease
Psychosocial work factors and blood pressure among 63 800 employees from The Netherlands in the Lifelines Cohort Study
OBJECTIVES: Previous studies on the association between psychosocial work factors and blood pressure mainly focused on specific occupations or populations and had limited sample sizes. We, therefore, investigated the associations between psychosocial work factors and blood pressure in a large general working population in the Netherlands. METHODS: We included 63â800 employees from the Netherlands, aged 18â65 years, with blood pressure measurements and a reliable job code at baseline. Psychosocial work factors (job strain, effortâreward imbalance (ERI) and emotional demands) in the current job were estimated with three recently developed psychosocial job exposure matrices. To examine the associations, regression analyses adjusted for covariates (age, sex, body mass index, education, monthly income, pack-years, smoking, alcohol consumption and antihypertensive medication (not included for hypertension)) were performed. RESULTS: Higher job strain was associated with higher systolic blood pressure (SBP) (B (regression coefficients) (95%âCI) 2.14 (1.23 to 3.06)) and diastolic blood pressure (DBP) (B (95%âCI) 1.26 (0.65 to 1.86)) and with higher odds of hypertension (OR (95%âCI) 1.43 (1.17 to 1.74)). Higher ERI was associated with higher DBP (B (95%âCI) 4.37 (3.05 to 5.68)), but not with SBP or hypertension. Higher emotional demands were associated with lower SBP (B (95%âCI) â0.90 (â1.14 to â0.66)) and lower odds of hypertension ((OR) (95%âCI) 0.91 (0.87 to 0.96)). CONCLUSIONS: In the general working population, employees in jobs with high job strain and ERI have higher blood pressure compared with employees with low job strain and ERI. Emotional demands at work are inversely associated with blood pressure
Occupational exposures and genetic susceptibility to occupational exposures are related to sickness absence in the Lifelines cohort study
In this cross-sectional study, we investigated the association between occupational exposures and sickness absence (SA), the mediating role of respiratory symptoms, and whether genetic susceptibility to SA upon occupational exposures exists. Logistic regression was used to examine associations and structural equation modelling was used for mediation analyses. Genetic susceptibility was investigated by including interactions between occupational exposures and 11 candidate single nucleotide polymorphisms (SNPs). Biological dust, mineral dust, and pesticides exposure were associated with a lower prevalence of any SA (OR (95% CI) = 0.72 (0.58â0.89), 0.88 (0.78â0.99), and 0.70 (0.55â0.89), respectively) while gases/fumes exposure was associated with a higher prevalence of long-term SA (1.46 (1.11â1.91)). Subjects exposed to solvents and metals had a higher prevalence of any (1.14 (1.03â1.26) and 1.68 (1.26â2.24)) and long-term SA (1.26 (1.08â1.46) and 1.75 (1.15â2.67)). Chronic cough and chronic phlegm mediated the association between high gases/fumes exposure and long-term SA. Two of 11 SNPs investigated had a positive interaction with exposure on SA and one SNP negatively interacted with exposure on SA. Exposure to metals and gases/fumes showed a clear doseâresponse relationship with a higher prevalence of long-term SA; contrary, exposure to pesticides and biological/mineral dust showed a protective effect on any SA. Respiratory symptoms mediated the association between occupational exposures and SA. Moreover, gene-by-exposure interactions exist
Transverse Polarization of ÎŁ+ (1189) in Photoproduction on a Hydrogen Target in CLAS
Experimental results on the ÎŁ+(1189) hyperon transverse polarization in photoproduction on a hydrogen target using the CLAS detector at Jefferson Laboratory are presented. The ÎŁ+(1189) was reconstructed in the exclusive reaction Îł+pâK0S+ÎŁ+(1189) via the ÎŁ+âpÏ0 decay mode. The K0S was reconstructed in the invariant mass of two oppositely charged pions with the Ï0 identified in the missing mass of the detected pÏ+Ïâ final state. Experimental data were collected in the photon energy range EÎł=1.0 â3.5 GeV (âs range 1.66â2.73 GeV). We observe a large negative polarization of up to 95% . As the mechanism of transverse polarization of hyperons produced in unpolarized photoproduction experiments is still not well understood, these results will help to distinguish between different theoretical models on hyperon production and provide valuable information for the searches of missing baryon resonances
First Measurement of Target And Double Spin Asymmetries for ep â epÏ° in the Nucleon Resonance Region Above the Î (1232)
The exclusive channel polarized proton(polarized e,e\u27 p)Ï0 was studied in the first and second nucleon resonance regions in the Q2 range from 0.187 to 0.770 GeV2 at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). Longitudinal target and beam-target asymmetries were extracted over a large range of center-of-mass angles of the Ï0 and compared to the unitary isobar model MAID, the dynamic model by Sato and Lee, and the dynamic model DMT. A strong sensitivity to individual models was observed, in particular for the target asymmetry and in the higher invariant mass region. This data set, once included in the global fits of the above models, is expected to place strong constraints on the electrocoupling amplitudes A 1/2 and S 1/2 for the Roper resonance N (1400) P11, and the N(1535)S11 and N(1520)D13 states
Precision Measurement of the Proton and Deuteron Spin Structure Functions g2 and Asymmetries A2
We have measured the spin structure functions g2p and g2d and the virtual
photon asymmetries A2p and A2d over the kinematic range 0.02 < x < 0.8 and 0.7
< Q^2 < 20 GeV^2 by scattering 29.1 and 32.3 GeV longitudinally polarized
electrons from transversely polarized NH3 and 6LiD targets. Our measured g2
approximately follows the twist-2 Wandzura-Wilczek calculation. The twist-3
reduced matrix elements d2p and d2n are less than two standard deviations from
zero. The data are inconsistent with the Burkhardt-Cottingham sum rule if there
is no pathological behavior as x->0. The Efremov-Leader-Teryaev integral is
consistent with zero within our measured kinematic range. The absolute value of
A2 is significantly smaller than the sqrt[R(1+A1)/2] limit.Comment: 12 pages, 4 figures, 2 table
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