Investigation of irisin levels in patients with major depressive disorder

Objective: Major depressive disorder (MDD) is a common psychiatric disorder. Irisin, produced by proteolysis of FNDC5, is thought to be an exercise -induced hormone that may play a critical role in inducing antidepressant -like effects. Our study aimed to investigate the relationship between irisin and newly diagnosed MDD patients. Methods: This cross-sectional study included 85 first-time diagnosed MDD patients and 81 healthy controls. Patients were diagnosed with MDD using the Structured Clinical Interview Questionnaire for DSM-IV Axis I and II Disorders (SCID-I, II) and the Hamilton Depression Scale (HAM -D). After an overnight fast, 5 ml of peripheral blood was drawn and serum irisin levels were measured. Results: When the effects of age and gender variables were controlled, no statistically significant difference in irisin levels was found between the groups. (F=1.832, p=0.178). When the effects of age, gender and body mass index variables were controlled and a partial correlation was made between irisin and HAMD scores, a significant negative correlation was found between irisin and HAMD scores (p<0.001, r=-0.523). The correlation analysis showed a statistically significant negative relationship between age and irisin levels (p=0.008, r=-0.205). However, when the effects of other variables were controlled and a partial correlation was made, no statistically significant relationship was found (p=0.610, r=-0.207). Conclusion: Our results indicate that irisin levels are associated with the severity of depression. Further studies are needed on the use of irisin as a potential biomarker for predicting clinical course and treatment response in patients with severe MDD

Correlation of suicidal thoughts and toxoplasmosis in patients with depression

Objective We investigated the correlation between serum anti-Toxplasma gondii IgG and suicidal thoughts in depressive patients. Methods Depressive patients with (n = 100) and without (n = 100) suicidal thoughts along with 100 healthy control subjects were recruited for this study. In all three groups, a semi-structured clinical interview form called Structured Clinical Interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) Axis-I Disorder (SCID-I), Hamilton Depression Rating Scale (HAMD), suicidal behavior scale, and a sociodemographic data form were completed. Sera from all participants were taken, and anti-toxoplasma IgG was measured by Enzyme Linked Immunosorbent Assay (ELISA)-Chemiluminescent Microparticle Immunoassay. Statistical analysis of the data was performed. Results The serum anti-toxoplasma IgG levels of patients with suicidal thoughts were significantly higher than those without suicidal thoughts and the controls, which were 80.04 +/- 40.66, 78 +/- 14.82, and 19.98 +/- 14.65, respectively, p < 0.001. There was no correlation between toxoplasma IgG and HAMD score in patients lacking suicidal thoughts (r = -0.112, p = 0.463). Conclusion This study shows a correlation between seropositivity for anti-Toxoplasma gondii IgG and depression with suicidal thoughts

Investigation of the relationship between hemogram parameters and procalcitonin levels in patients with psychiatric diseases

Introduction: This study aimed to evaluate the relationship between the hemogram parameters and the levels of procalcitonin, serum C-reactive protein, and inflammation in inpatients with psychiatric disorders. Material and methods: The study population consisted of 549 inpatients treated between January 2018 and December 2020. Data were obtained retrospectively from computer records and inpatient files. Only the first hospitalization of each patient was evaluated, and 199 patients were included in the study. The researchers examined the parameters including platelet activation, neutrophil lymphocyte ratio, monocyte lymphocyte ratio, platelet count, mean platelet volume, platelet distribution width, platelet lymphocyte ratio, and procalcitonin levels in patients and compared them with findings obtained from a control group. Results: Increased levels of C-reactive protein and decreased levels of platelets were observed in patients with schizophrenia, bipolar disorder, depressive disorder, and anxiety disorder. Increased platelet distribution width, platelet lymphocyte ratio, and neutrophil lymphocyte ratio were observed in patients with schizophrenia. The patients with bipolar disorder had increased mean platelet volume while patients with depressive disorder had an increased monocyte lymphocyte ratio. Procalcitonin levels increased in patients with anxiety disorder and depressive disorder. Discussion: Platelet activity can be an important criterion to investigate the etiopathogenesis underlying the inflammatory process in schizophrenia, bipolar disorder, depressive disorder, and anxiety disorders. To our knowledge, this is the first study to describe a positive correlation between increased monocyte lymphocyte ratio and procalcitonin levels in depressive disorder, and a positive correlation between increased procalcitonin levels and anxiety disorder and depressive disorder

Effect of personality traits on functioning and long-term treatment in patients with bipolar disorder

Amaç: Bipolar bozukluk (BB) oldukça önemli bir sağlık sorunu olup, ciddi sosyal ve ekonomik sonuçlar doğurmaktadır. BB tanılı olguların koruyucu sağaltımının etkin şekilde planlanması ve hastanın yaşam kalitesinin en iyi düzeyde tutulması tedavinin ana hedefidir. Çalışmamızda BB tanısı ile izlenen hastalarda, kişilik özelliklerine göre işlevsellik ile koruyucu sağaltıma verilen yanıt düzeylerinde bir farklılık olup olmadığının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya ayaktan tedavi biriminde takip edilen ve çalışmaya katılmak için gönüllü olan BB tanılı 80 hasta dahil edilmiştir. Tüm olgulara Bipolar Bozukluk İşlevsellik Ölçeği (BBİÖ), Young Mani Derecelendirme Ölçeği (YMDÖ), Hamilton Depresyonu Derecelendirme Ölçeği(HDDÖ), Eysenck Kişilik Anketi-Gözden Geçirilmiş Kısaltılmış Formu-(EKA-GGK) ve Koruyucu Sağaltım Değerlendirme Ölçeği (KSDÖ) uygulanmıştır. Bulgular: Çalışmaya katılan hastaların 57’si kadın (%71.3), 23’ü (%28.7) ise erkekti. Psikotisizm kişilik boyutu ile koruyucu sağaltıma yanıt arasında zayıf ancak, anlamlı negatif bir ilişki olduğu saptandı. Diğer kişilik boyutları incelendiğinde ise aralarında anlamlı bir ilişki bulunamadı. Sonuç: Koruyucu Sağaltım Değerlendirme Ölçeği’nin kullanılabilirliği ile ilgili daha fazla çalışmaya ihtiyaç vardır. Bipolar bozuklukta kişiye en uygun koruyucu sağaltımı olabildiğince erken belirlemek önemli bir hedeftir. Kişilik özelliklerinin bu anlamda belirleyici rolünün yerinin ve büyüklüğünün tam olarak saptanması amacıyla yeni çalışmalara ihtiyaç vardır.Objective: Bipolar disorder (BD) is a very important health problem and has serious social and economic consequences. The main goal of the treatment is to regulate the most effective and optimal quality of life of the patients with the diagnosis of BD. In our study, we aimed to determine whether there is a difference in scores of functionality and long-term treatment response degrees related to personality traits. Materials and Methods: Eighty patients with bipolar disorder who were followed up in an outpatient unit and volunteered to participate in the study were included in the study. Bipolar Disorder Functioning Scale (BDFS), Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), Eysenck Personality Questionnaire Revised-Short Form (EPQR-S) and Long-term Treatment Responce Scale (ALDA) were administered to all subjects. Results: 57 (71.3%) patients of the sample was woman and 23(28.7%) of them was man. It appears that there is a weak but significant negative correlation between psychotisizm dimension and response to the long-term treatment. When we examined tha other aspects of the personality dimensions, no significant correlation was found. Conclusions: It seems that there is a need for more studies about the convenience of ALDA. In bipolar disorder; determining the most suitable treatment plan, as early as it could be, for indivudials is a very important goal and in this context, there is a need for more studies to understand the decisive role of personality traits on treatment

Bipolar Bozukluk Tanısı ile İzlenen Hastalarda İşlevsellik ve Kişilik Özelliklerinin Koruyucu Tedavi Üzerine Olan Etkisinin İncelenmesi

Amaç: Bipolar bozukluk (BB) oldukça önemli bir sağlık sorunu olup, ciddi sosyal ve ekonomik sonuçlar doğurmaktadır. BB tanılı olguların koruyucu sağaltımının etkin şekilde planlanması ve hastanın yaşam kalitesinin en iyi düzeyde tutulması tedavinin ana hedefidir. Çalışmamızda BB tanısı ile izlenen hastalarda, kişilik özelliklerine göre işlevsellik ile koruyucu sağaltıma verilen yanıt düzeylerinde bir farklılık olup olmadığının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya ayaktan tedavi biriminde takip edilen ve çalışmaya katılmak için gönüllü olan BB tanılı 80 hasta dahil edilmiştir. Tüm olgulara Bipolar Bozukluk İşlevsellik Ölçeği (BBİÖ), Young Mani Derecelendirme Ölçeği (YMDÖ), Hamilton Depresyonu Derecelendirme Ölçeği(HDDÖ), Eysenck Kişilik Anketi-Gözden Geçirilmiş Kısaltılmış Formu-(EKA-GGK) ve Koruyucu Sağaltım Değerlendirme Ölçeği (KSDÖ) uygulanmıştır. Bulgular: Çalışmaya katılan hastaların 57’si kadın (%71.3), 23’ü (%28.7) ise erkekti. Psikotisizm kişilik boyutu ile koruyucu sağaltıma yanıt arasında zayıf ancak, anlamlı negatif bir ilişki olduğu saptandı. Diğer kişilik boyutları incelendiğinde ise aralarında anlamlı bir ilişki bulunamadı. Sonuç: Koruyucu Sağaltım Değerlendirme Ölçeği’nin kullanılabilirliği ile ilgili daha fazla çalışmaya ihtiyaç vardır. Bipolar bozuklukta kişiye en uygun koruyucu sağaltımı olabildiğince erken belirlemek önemli bir hedeftir. Kişilik özelliklerinin bu anlamda belirleyici rolünün yerinin ve büyüklüğünün tam olarak saptanması amacıyla yeni çalışmalara ihtiyaç vardır

Symptomatic Remission Determines Functional Improvement and Quality of Life in Schizophrenia

Introduction: Schizophrenia is a chronic illness that negatively affects the quality of life and psychosocial functions. Defined criteria to assess remission in schizophrenia are considered to be useful in the longterm follow-up of patients and in discriminating diagnostic factors. This study investigated the quality of life and functionality in schizophrenia patients in symptomatic remission (R-Sch) and not in remission (Non-R-Sch). Methods: Sociodemographic data were collected for 40 R-Sch and 40 Non-R-Sch patients, and the following scales were administered: the Clinical Global Impression-Severity (CGI-S) Scale; Positive and Negative Syndrome Scale (PANSS), World Health Organization Quality of Life Questionnaire-Short Form, Turkish Version (WHOQOL-BREF-TR), Quality of Life Scale for Schizophrenia Patients (QLS), and Global Assessment of Functioning Scale (GAF). Results: The total and all subscale scores of PANSS and the CGI-S score were significantly lower in the R-Sch group than in the Non-R-Sch group, whereas the GAF scores and all subscales of QLS and WHOQOL-BREF-TR were significantly higher. Conclusion: This study demonstrates that improvement in symptoms in schizophrenia patients improves quality and functionality in all areas of life, suggesting that an improvement in symptoms is the most important determinant of functional recovery in the treatment of schizophrenia

İki börülce çeşitinde farklı ekim sıklıklarının bazı bitkisel ve tarımsal özelliklere etkisi üzerine bir araştırma

TEZ373Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 1987.Kaynakça (s.42-45) var.vi, 47 s. ; 30 cm.

Lipoprotein subfractions in patients with depression: The lipoprint system Lipoprotein sub-fractions and depression

Aim: The aim of the study is to investigate the relationship between depression and changes in 25-OH Vitamin D and Lipoprotein serum levels, which have been suggested to be associated with Central Nervous System neurotransmission and certain psychiatric disorders. Material and Methods: The study included a patient group consists of 40 depressive individuals who have applied to the Psychiatry outpatient clink of our hospital and have been first diagnosed with depression according to SCID-1 (Structured Clinical Interview for DSM IV Axis I Disorders) criteria and had no psychiatric or systemic disease that could affect the result, as well as a control group of 40 healthy individuals with similar demographic characteristics. In the collected serum samples. 25-OH vitamin D, LDL, HDL, VLDL, total cholesterol, and TG levels were measured enzymatically and spectrophotometrically: Apolipoprotein Al and Bl00 levels were measured nephelometrically, LDL and HDL subfractions were measured using the Upoprint System, and then the results were evaluated statistically. Results: Atherogenic LDL 3 and LDL 4 were significantly higher In the patient group (p=0.001 and p=0.0155, respectively). The mean LDL particle diameter (LDL Mean) was significantly lower in the patient group (13-0.0017). There was no significant difference between the patient and control groups in terms of Buoyant LDL, but Small Dense LDL levels were significantly higher in the patient group (p=0.008 and p<0.001, respectively). LDL 1 Subfraction level of the patient group was statistically significantly higher than the control group (p 0.0046). There was no significant difference in LDL 2 (p=0.3560). Discussion: According to the results, LDL 3, LDL 4, and Small Dense LDL serum levels of the patients with depression were found to be higher. The fact that Small Dense LDL has a long circulation time in the blood, atherogenic and proinflammatory properties, better penetrability into the arterial intima layer and is considered as a risk factor in the CVD group, suggests that the risk of atherosclerosis, inflammation and CVD may be higher in patients with depression

Prematür Ejakülasyon Hastalarında Mizaç ve Karakter Farklılıkları

Giriş: Prematür ejakülasyon’un etiyolojisi ile ilgili çok miktarda biyolojik ve psikolojiteorilerin olmasına karşın tartışmalar hala sürmektedir. Mizaç ve karakter envanteile prematür ejakülasyonlu hastaların kişilik yapısını araştırmayı amaçladık. Yöntem: Kırk prematür ejakülasyonlu hasta, 40 sağlıklı kontrol grubuyla eşleştirildÇalışmaya katılanlardan mizac ve karakter envanteri ve genel demografik bilgi formunu doldurması istendi. Bulgular: Toplam yenilik arayışı ve alt ölçeği keşfetme ve heyacan duyma prematür ejakülasyonlu hastalarda kontrol grubuna göre anlamlı olarak yüksek(p<0,05). Toplam zarardan kaçınma ve alt ölçeği belirsizlik korkusu prematüejakülasyonlu hastalarda kontrol grubuna göre anlamlı olarak düşük bulund(p<0,05). Beck depresyon skorun da prematür ejakülasyonlu hastalar kontrol grubundan anlamlı olarak yüksekti. Sonuç: Prematür ejakülasyonlu kişiler daha dürtüsel (heyecanlı), daha öfkeldaha heyacanlı ve zararlı davranışlara daha az yatkındılar. Mevcut bulgular prematür ejakülasyonun nörobiyolojik ve psikolojik kökenli olduğununu desteklemeğilimindedir. (Nöropsikiyatri Arşivi 2012; 49: 332-336)ntroduction: The debate on the etiology of premature ejaculation is still ongoing although there was huge amount of biological and psychological theories. We aimed to investigate the personality structure of patients with premature ejacula- ion via temperament and character inventory. Methods: Forty patients with premature ejaculation and a matched number of healthy people were included. Participants were asked to fill out a questionnaire booklet with separate sections for general demographic information and the tem- perament and character inventory. Results: Total novelty seeking scores and subscale 1 (exploration-excitability) cores in premature ejaculation patients were significantly higher than in control groups (p<0.05). Total harm avoidance scores and harm avoidance subscale 2 (fear of uncertainty) scores in premature ejaculation patients was found significantly low- er than in control group (p<0.05). Beck depression score was significantly higher in patients with premature ejaculation than in control groups. Discussion: Men with premature ejaculation are more impulsive (excitant), more empered, more excitable and less prone to harmful behavior. Current findings tend o reinforce premature ejaculation based upon combination of neurobiological and psychological reasons. (Arc&shy;hi&shy;ves of Neu&shy;ropsy&shy;chi&shy;atry 2012; 49: 332-336