Treatment of relapsing multiple sclerosis in Hungary – consensus recommendation from the Hungarian neuroimmunology society

Multiple sclerosis (MS) may impact quality of life, careers and family plans of the affected individuals. The current treatments with disease modifying therapies aim to prevent people with MS (pwMS) from disability accumulation and progression. Different countries have different reimbursement policies resulting in inequalities in patient care among geographical regions. Access to anti-CD20 therapies for relapsing MS is restricted in Hungary because therapy of individual cases only is reimbursed. In the light of the latest research and national guidelines, 17 Hungarian MS experts agreed on 8 recommendations regarding relapsing pwMS using the Delphi round method. Strong agreement (> 80%) was achieved in all except one recommendation after three rounds, which generated a fourth Delphi round. The experts agreed on treatment initiation, switch, follow-up and discontinuation, as well as on special issues such as pregnancy, lactation, elderly population, and vaccination. Well-defined national consensus protocols may facilitate dialogue between policymakers and healthcare professionals and thus contribute to better patient care in the long run

Egy luxusmárka kommunikációjának elemzése és bemutatása a Louis Vuitton brand alapján

Dolgozatomban kifejtem azt a megállapítást, miszerint a divatot és az aktuális trendeket a luxusmárkák diktálják szezonról szezonra, melynek reprezentálásához és kommunikálásához különböző kontextusokat és marketingstratégiákat használnak fel. A világ egyik vezető luxusmárkája, a Louis Vuitton stratégiáin keresztül elemzem a brand kialakulását és fejlődését a marketing szempontjából - a kezdetektől a mai napig - a tradíció és innováció fontosságának figyelembe vételével. A brandépítés és a kulturális, médiában megjeleníthető kontextusok együttes elemzésével kapok választ a Louis Vuitton brand sikeresen működő marketingkommunikációjára.BSc/BAKommunikáció- és MédiatudományB

Investigating the knowledge of and public attitudes towards genetic testing within the Visegrad countries: a cross-sectional study

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A fizikai fényvédők biológiai hatásainak áttekintése = Overview of the biological effects of physical sunscreens

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SerpinB2 is involved in cellular response upon UV irradiation

Abstract Ultraviolet light induced pyrimidine dimer is a helix distortion DNA damage type, which recruits repair complexes. However, proteins of these complexes that take part in both DNA damage recognition and repair have been well-described, the regulation of the downstream steps of nucleotide excision repair (NER) have not been clearly clarified yet. In a high-throughput screen, we identified SerpinB2 (SPB2) as one of the most dramatically upregulated gene in keratinocytes following UV irradiation. We found that both the mRNA and the protein levels of SPB2 were increased upon UV irradiation in various cell lines. Additionally, UV damage induced translocation of SPB2 from the cytoplasm to the nucleus as well as the damage induced foci formation of it. Here we show that SPB2 co-localizes with XPB involved in the NER pathway at UV-induced repair foci. Finally, we demonstrated that UV irradiation promoted the association of SPB2 with ubiquitylated proteins. In basal cell carcinoma tumour cells, we identified changes in the subcellular localization of SPB2. Based on our results, we conclude that SPB2 protein has a novel role in UV-induced NER pathway, since it regulates the removal of the repair complex from the damaged site leading to cancerous malformation