Développement d'une méthode de production de matériaux de référence pour le contrôle de la qualité des analyses des composés organiques volatils réalisées en air intérieur

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Étude du devenir des composés organostanniques butylés et phénylés Au cours d'un dragage portuaireCas du Port d'Audenge

The legislation introduced in 1982, prohibiting the use of tributyltin (TBT)-containing paints on vessels under 25 meters lengths, did not totally eliminate this biocide, toxic to aquatic life, in marine environment. TBT, preferably absorbed on finest particles in mud and sediments, is a potential source of contamination during civil engineering works such as dredgings. The results of an analytical study, realised during the dredging of the port of Audenge, has pointed out that the sludge treatment process, including both air oxidation and light exposure, minimizes organotin contents of the water effluent.L'arrêté promulgué en 1982 interdisant l'utilisation du tributylétain (TBT) dans les peintures antisalissures pour les bateaux de moins de 25 mètres et les structures immergées n'a pas fait totalement disparaître du milieu marin ce biocide à haut risque pour le biotope. Durablement fixé aux vases et aux sédiments, il est susceptible d'être libéré dans l'eau au cours de travaux de génie civil, tels que les dragages. Les résultats d'une étude analytique effectuée au cours du dragage du port d’Audenge montrent que la technique employée, basée sur une oxydation et une exposition à la lumière des boues au moyen d'une série de bassins de décantation, permet de réaliser une décontamination efficace des rejets

Certified reference materials for breath alcohol control - the ALCOREF project

The Joint Research Project Alcoref “Certified forensic alcohol reference materials” is a multi-partner trans-national project within the targeted call “Research Potential” of the European Metrology Programme for Innovation and Research (EMPIR) launched in 2016. The European Commission has estimated that about one quarter of road traffic deaths are due to alcohol. The European status report on road safety of the World Health Organization Regional Office for Europe therefore stated that, among other measures, better legislation and enforcement of alcohol control is needed in several countries. In particular, the report demands that unrestricted access to alcohol breath testing, using breath analysers of equivalent and agreed standard, should be implemented throughout Europe. These high standards for tests, verification and calibration of breath alcohol analysers should meet some requirements of the recommendation R 126 defined by the International Organization of Legal Metrology (OIML) and European standards (EN 16280 and EN 15964). The specific objective of this project is to establish regional research and metrological capacity for the development of certified forensic alcohol reference materials for the law enforcement of drink-driving regulations

Metrological Needs for Monitoring Aquatic Environments: From the Demonstration of Metrological Traceability to the Decision Making Process

In Europe, the implementation of the Water Framework Directive WFD, in 2001, marks a strong standpoint. In addition to its objectives of a return to good chemical and good ecological status by the year 2015, it fixes the achievement of trends over space and time. The new requirements that arise from the WFD put considerable financial pressure on water management authorities. Because the overall decision-making process relies most of the time on acquired data, it puts considerable pressures on the display of high quality biological as well as chemical environmental measurements. However, performing measurements implies that i) the demonstration of their metrological traceability ii) the evidence of their achievement thanks to accurate and sensitive analytical methods and iii) their statement with a reliable estimate of expanded uncertainty is thoroughly addressed. Moreover, the measurement representativeness, especially in highly dynamic environment, is of prime interest in a context where comparability over space and time is needed. As a consequence, considerable challenges are dwelt on metrologists with great emphasis on parameters that are under regulation. This paper will discuss a panorama of the unavoidable metrological questions that have to be addressed: from the definition of the measurand to the final estimation of uncertainty; from the initial performances demonstration of methods to the final demonstration of mastery and capabilities through inter comparison laboratories and reference materials. A focus will be made on upcoming alternative monitoring approaches that are seldom addressed from a metrological point of view

Reliability of organic compounds measurement in enviromental monitoring. The key role of analytical standard substance. A study case on alkylphenols

The overall management and decision making system driven by the Water Framework Directive (WFD) and other European water policies is strongly dependent on the quality of monitoring data. Performing fit for purpose measurements implies the demonstration of their metrological traceability, their procuration according to accurate and sensitive analytical methods and a realistic estimate of expanded uncertainty. This can only be achieved by the provision of reference measurement standard substances, whenever possible traceable to the SI, which serve as reference points for the implementation of a traceability infrastructure supporting a monitoring network in Europe. Routine laboratories operating in French water bodies monitoring program have repeatedly expressed to AQUAREF their difficulties regarding alkyphenols, one of the priority substances of the WFD. Accordingly, LNE and INERIS handled a study that aims at assessing the purity of nonylphenols commercially available analytical standard and discusses its impacts. The work highlights that: identity of the organic analytical standard substance reference materials should be clearly documented and demonstrated, purity assessment should be reported with a reliable uncertainty evaluation

Assessing the performance of measurement devices for continuously monitoring of organic matter and nutrient in river water

The evaluation of the metrological performance parameters of 27 water quality monitoring devices for continuously measuring nutrients and organic matter in river waters was conducted both under controlled conditions in the laboratory and under field conditions during a 3-month field trial. It consisted of (i) designing protocols to assess metrological performance parameters under controlled and field conditions of monitoring devices (ii) selecting a site to conduct a field trial (iii) selecting monitoring devices and (iv) conducting the testing. The results obtained for the devices measuring nitrate, total nitrogen and organic carbon are presented in this paper. The performances evaluated under controlled conditions were very acceptable with the vast majority of the monitoring devices being characterized by a repeatability below 5 %, a bias below 10 %, a linearity deviation below 10 % and a combined expanded uncertainty below 15 %. Moreover, the monitoring devices tested were found to have quantification limits suitable with regard to the concentration levels measured in the Oise River between October 2015 and February 2016. Finally, from the results obtained as well as the feedback on testing a great variety of monitoring devices, it was possible to draw some recommendations for improving the measurements using the devices tested

Quantitative detection of amyloid-β peptides by mass spectrometry: state of the art and clinical applications

International audienceAlzheimer's disease (AD) is the most common form of dementia in humans, and a major public health concern with 35 million of patients worldwide. Cerebrospinal fluid (CSF) biomarkers being early diagnostic indicators of AD, it is essential to use the most efficient analytical methods to detect and quantify them accurately. These biomarkers, and more specifically amyloid-β (Aβ) peptides, are measured in routine clinical practice using immunoassays. However, there are several limits to this immunodetection in terms of specificity and multiplexing of the multiple isoforms of the Aβ peptides. To overcome these issues, the quantification of these analytes by mass spectrometry (MS) represents an interesting alternative, and several assays have been described over the past years. This article reviews the different Aβ peptides quantitative MS-based approaches published so far, compares their pre-analytical phase, and the different quantitative strategies implemented that might be suitable for clinical applications

Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based calibration

International audienc

DCE en Manche-Atlantique : Essais inter-laboratoires sur les mesures d’abondance des zostères (Zostera marina et Zostera noltei). Validation de protocoles et recommandations

Ce rapport a été réalisé dans le cadre du programme scientifique et technique AQUAREF pour les années 2016- 2018, au titre de l’action « B » « Mettre en oeuvre les méthodes de bioindication dans la surveillance et l’évaluation»

Metrological Needs for Monitoring Aquatic Environments: From the Demonstration of Metrological Traceability to the Decision Making Process

In Europe, the implementation of the Water Framework Directive WFD, in 2001, marks a strong standpoint. In addition to its objectives of a return to good chemical and good ecological status by the year 2015, it fixes the achievement of trends over space and time. The new requirements that arise from the WFD put considerable financial pressure on water management authorities. Because the overall decision-making process relies most of the time on acquired data, it puts considerable pressures on the display of high quality biological as well as chemical environmental measurements. However, performing measurements implies that i) the demonstration of their metrological traceability ii) the evidence of their achievement thanks to accurate and sensitive analytical methods and iii) their statement with a reliable estimate of expanded uncertainty is thoroughly addressed. Moreover, the measurement representativeness, especially in highly dynamic environment, is of prime interest in a context where comparability over space and time is needed. As a consequence, considerable challenges are dwelt on metrologists with great emphasis on parameters that are under regulation. This paper will discuss a panorama of the unavoidable metrological questions that have to be addressed: from the definition of the measurand to the final estimation of uncertainty; from the initial performances demonstration of methods to the final demonstration of mastery and capabilities through inter comparison laboratories and reference materials. A focus will be made on upcoming alternative monitoring approaches that are seldom addressed from a metrological point of view