Effects of Leading Edge Sweep on the Cavitating Characteristics of Inducer Pumps

It is well known that leading edge sweep has a favorable effect on the cavitation of turbomachines. However, the mechanisms of the improvement have not been made clear. It has been shown that the lift and the drag on a cavitating swept single hydrofoil can be correlated fairly well based on the velocity component normal to the leading edge. In the present paper, such correlations for swept cascades are derived and the results are examined, neglecting the full geometrical effects of the inducer rotor. It is shown that the correlations can simulate the developments of various types of cavitation, including alternate blade cavitation, rotating cavitation, and cavitation surge. This result is based on the observation that the steady cavity length, as well as the developments of various types of cavitation, is fairly well predicted by the correlation

Note on norm and pointwise convergence of exponential products and their integral kernels for the harmonic oscillator

金沢大学大学院自然科学研究科The aim of this paper is to study the exponential symmetric product formula for the semigroup of the one-dimensional harmonic oscillator to discuss its convergence pointwise of the integral kernels as well as in norm with sharp optimal error bound. © 2007 Birkhaueser

Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients

Quasispecies of hepatitis B virus (HBV) with variations in the major hydrophilic region (MHR) of the HBV surface antigen (HBsAg) can evolve during infection, allowing HBV to evade neutralizing antibodies. These escape variants may contribute to chronic infections. In this study, we looked for MHR variants in HBV quasispecies using ultradeep sequencing and evaluated the relationship between these variants and clinical manifestations in infected patients. We enrolled 30 Indonesian patients with hepatitis B infection (11 with chronic hepatitis and 19 with advanced liver disease). The most common subgenotype/subtype of HBV was B3/adw (97%). The HBsAg titer was lower in patients with advanced liver disease than that in patients with chronic hepatitis. The MHR variants were grouped based on the percentage of the viral population affected: major, ≥20% of the total population; intermediate, 5% to <20%; and minor, 1% to <5%. The rates of MHR variation that were present in the major and intermediate viral population were significantly greater in patients with advanced liver disease than those in chronic patients. The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R. The major population of MHR variants causing impaired of HBsAg secretion (e.g., G119R, Q129R, T140I, and G145R) was detected only in advanced liver disease patients. This is the first study to use ultradeep sequencing for the detection of MHR variants of HBV quasispecies in Indonesian patients. We found that a greater number of MHR variations was related to disease severity and reduced likelihood of HBsAg titer