Biodegradable PCL/fibroin/hydroxyapatite porous scaffolds prepared by supercritical foaming for bone regeneration

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First steps for the development of silk fibroin-based 3D biohybrid retina for age-related macular degeneration (AMD)

Age-related macular degeneration is an incurable chronic neurodegenerative disease, causing progressive loss of the central vision and even blindness. Up-to-date therapeutic approaches can only slow down he progression of the disease. Objective. Feasibility study for a multilayered, silk fibroin-based, 3D biohybrid retina. Approach. Fabrication of silk fibroin-based biofilms; culture of different types of cells: retinal pigment epithelium, retinal neurons, Müller and mesenchymal stem cells ; creation of a layered structure glued with silk fibroin hydrogel. Main results. In vitro evidence for the feasibility of layered 3D biohybrid retinas; primary culture neurons grow and develop neurites on silk fibroin biofilms, either alone or in presence of other cells cultivated on the same biomaterial; cell organization and cellular phenotypes are maintained in vitro for the seven days of the experiment. Significance. 3D biohybrid retina can be built using silk silkworm fibroin films and hydrogels to be used in cell replacement therapy for AMD and similar retinal neurodegenerative diseases

Parent-child positive touch: Gender, age and task differences.

This study examined gender, age, and task differences in positive touch and physical proximity during mother-child and father-child conversations. Sixty-five Spanish mothers and fathers and their 4- (M = 53.50 months, SD = 3.54) and 6-year-old (M = 77.07 months, SD = 3.94) children participated in this study. Positive touch was examined during a play-related storytelling task and a reminiscence task (conversation about past emotions). Fathers touched their children positively more frequently during the play-related storytelling task than did mothers. Both mothers and fathers were in closer proximity to their 6-year-olds than their 4-year-olds. Mothers and fathers touched their children positively more frequently when reminiscing than when playing. Finally, 6-year-olds remained closer to their parents than did 4-year-olds. Implications of these findings for future research on children’s socioemotional development are discussed

Structural properties of protein and their role in polymer nanocomposites

The growing concern over the environment raises the question of\u3cbr/\u3ebiodegradability and renewability in numerous fields, including materials and\u3cbr/\u3eenergy. Therefore, industries and researchers focus more on the development of biomaterials generated from natural sources. In this context, proteins and their unique properties made them ideal candidates to be used in different novel applications and are not limited to films, hydrogels, biological tissue engineering, and polymer composites. In this chapter, authors highlight the different sources of protein and their structural properties. Then, the extraction methods are discussed in detail. Further, the different processing methods to prepare the protein-based composites were explained. In overall, this chapter aims to highlight the recent developments of protein-based materials in different fields, based on the literature