A Generalized Treatment for the Kinetics of Two Consecutive Irreversible Second Order Reactions: Kinetics of Hydrolysis of Di-n-butyl Phthalate

220-22

Kinetics & Mechanism of Base-catalysed Hydrolysis of Formamide-Effect of Alkalinity on the Reactive Tetrahedral Addition Intermediates

961-96

Rancang Bangun Timer Drag Berbasis Arduino Uno

The development of the world of information technology is increasing day by day. Almost all aspects of human life are now inseparable from the influence of technology. Technology can make it easier for someone to do everything, as is the case in the world of automotive sports which is currently increasingly developing. Because on this basis, the need for fast and accurate information technology is becoming increasingly high. The aim of this research is to design a drag timer tool based on Arduino Uno. If the stage 1 sensor detects it then the white LED 1 will light up and if the stage 2 LED detects it is a sign that the driver is ready to start, if the driver is ready then the start button will be pressed and the yellow LED will run and the time will start counting, if the finish sensor detects it then wireless will send data to the Arduino and will be displayed on the P 10 display. In the results of testing the stopwatch on the tool, an average error of 3.22% was obtained, for ultrasonic sensor testing the average error value was 4.95% and for sensor testing distance, the average error value was 6.49%

Motion Planning for Autonomous Ground Vehicles Using Artificial Potential Fields: A Review

Autonomous ground vehicle systems have found extensive potential and practical applications in the modern world. The development of an autonomous ground vehicle poses a significant challenge, particularly in identifying the best path plan, based on defined performance metrics such as safety margin, shortest time, and energy consumption. Various techniques for motion planning have been proposed by researchers, one of which is the use of artificial potential fields. Several authors in the past two decades have proposed various modified versions of the artificial potential field algorithms. The variations of the traditional APF approach have given an answer to prior shortcomings. This gives potential rise to a strategic survey on the improved versions of this algorithm. This study presents a review of motion planning for autonomous ground vehicles using artificial potential fields. Each article is evaluated based on criteria that involve the environment type, which may be either static or dynamic, the evaluation scenario, which may be real-time or simulated, and the method used for improving the search performance of the algorithm. All the customized designs of planning models are analyzed and evaluated. At the end, the results of the review are discussed, and future works are proposed

Grading complication following radical cystectomy and ileal conduit for bladder cancer using clavien grading system

Objective: To determine the 30-day complication rate of radical cystectomy and urinary diversion using a validated system.Study Design: An analytical descriptive study. Place and Duration of Study: The Aga Khan University Hospital, Karachi, from 1990 to 2010.Methodology: Patients who had undergone ileal conduit (IC) formation, following radical cystectomy (RC) for muscle invasive transitional cell carcinoma, were studied, using a prospectively maintained data base. Basic details were determined, complications were noted and graded according to the modified Clavien grading system (CG). Results were presented using descriptive statistics. Results: Of all the RC performed at this hospital 89 patients received IC. Of them 75 were male and 14 female. Mean age was 60 years. Mean duration of hospital stay was 14 days. Ten patients each received pre-operative chemotherapy and radiotherapy, respectively. Mean duration of surgery was 8.2 hours, with mean estimated blood loss of 1334 ml. Preoperative radiotherapy was associated with more complications. No other factor like ASA, co-morbidities, blood loss or duration of stay influenced the complications. Fifty patients (56.2%) did not have any complications. Most common complication of wound infection was seen in 7 patients (CG-2), followed by uretero-ileal leakage in 5, requiring percutaneous intervention under local anaesthesia (GC-3a). Mortality rate was 4.5%, classified as CG-V. Conclusion: Radical cystectomy with Ileal conduit is a major procedure with a good safety profile at this institute. Longterm follow up is still needed to evaluate delayed complications and quality of life

Epidermal Growth Factor Receptor (EGFR) as a Prognostic Marker: an Immunohistochemical Study on 315 Consecutive Breast Carcinoma Patients

Objective: To assess the independent and interdependent prognostic value of epidermal growth factor receptor (EGFR) in carcinoma of breast in female population. The Type I family of growth factor receptors includes epidermal growth factor receptor (EGFR also known as EGFRI). Methods: The expression of EGFR protein was analysed immunohistochemically on 315 tumour specimens of infiltrating ductal carcinoma of breast. These patients also had axillary lymph nodes sampling. Results: Overexpression and/or amplification of EGFR was observed in 70 (22.00%) tumours. Eleven (16%) were grade I, 43 (61%) grade II and 16 (23%) grade Ill tumours. Axillary lymph node metastasis had significant correlation with intensified positivity of EGFR (p\u3c 0.05). Significant number of EGFR positive patients developed local recurrence and distant metastases to brain, liver and bone (p\u3c 0.05). EGFR positivity showed significant correlation with the disease free and overall survival (p\u3c 0.05). At a median follow-up of48 (4 years) months in EGFR positive patients, the overall survival was 3.39 years and disease free survival was 2.86 years. EGFR negative tumour patients showed a better survival. In this group the overall survival was 4.62 years and the disease free survival was 4 years. Conclusion: EGFR analysis can be a useful indicator for the selection of patients who are at the high risk, for hormonal therapy decisions and can be useful as a target for new treatment modalities

Management of oesophageal foreign bodies

AbstractObjectiveThe aim of the study was to evaluate the management of foreign bodies in the oesophagus and to determine the association with socioeconomic status.MethodsThis cross-sectional analytical study was carried out in the Department of Ear, Nose and Throat and head and neck surgery of Bahawal Victoria Hospital affiliated with Quaid-i-Azam Medical College, Bahawalpur, Pakistan, between December 2012 and May 2013. The medical records of 34 consecutive cases of foreign body ingestion were searched, and the data were recorded on a questionnaire prepared for this purpose.ResultsThe average age of the patients was 10.38 years; 29 cases (85.2%) were in children under 12 years. There were 18 females (52.9%) and 16 males (47.1%). Thirty patients (88%) presented with a history of dysphagia, and 25 (73.6%) had vomiting. The site of impaction was the post-cricoid region in 22 patients (66%), the lower oesophagus in 5 (15%), the mid-oesophagus in 4 (13%), the posterior pharyngeal wall in 1 (3%) and the pyriform fossa in 1 patient (3%). Coins were the most common foreign body (61.8%). Socioeconomic analysis showed that 18 patients (52.9%) were in the low socioeconomic class, 12 (35.3%) in the middle class and 4 (11.8%) in the upper class.ConclusionThe presence of a foreign body in the oesophagus is a serious condition, and early removal is recommended. Foreign body lodgement is commoner among poor families

Preliminary structure-activity relationship studies on some novel s-substituted aliphatic analogues of 5-{1-[(4- chlorophenyl) sulfonyl]-3-piperidinyl}-1, 3, 4-oxadiazol-2-yl sulfide

Purpose: To study the structure-activity relationships of synthetic multifunctional sulfides through evaluation of lipoxygenase and anti-bacterial activities.Methods: S-substituted derivatives of the parent compound 5-(1-(4- chlorophenylsulfonyl) piperidin-3- yl)-1, 3, 4-oxadiazole-2-thiol were synthesized through reaction with different saturated and unsaturated alkyl halides in DMF medium, with NaH catalyst. Spectral characterization of each derivative was carried out with respect to IR, 1H - NMR, 13C - NMR and EI - MS. The lipoxygenase inhibitory and antibacterial activities of the derivatives were determined using standard procedures.Results: Compound 5e exhibited higher lipoxygenase inhibitory potential than the standard (Baicalein®), with % inhibition of 94.71 ± 0.45 and IC50 of 20.72 ± 0.34 μmoles/L. Compound 5b showed significant antibacterial potential against all the bacterial strains with % inhibition ranging from 62.04 ± 2.78, 69.49 ± 0.41, 63.38 ± 1.97 and 59.70 ± 3.70 to 78.32 ± 0.41, while MIC ranged from 8.18 ± 2.00, 10.60 ± 1.83, 10.84 ± 3.00, 9.81 ± 1.86 and 11.73 ± 5.00 μmoles/L for S. typhi, E. coli, P. aeruginosa, B. subtilis and S. aureus, respectively. Compounds 5d, 5e and 5g showed good antibacterial activity against S. typhi and B. subtilis bacterial strains.Conclusion: The results suggest that compound 5e bearing n-pentyl group is a potent lipoxygenase inhibitor, while compound 5b with n-propyl substitution is a strong antibacterial agent. In addition, compounds 5d, 5e and 5g bearing n-butyl, n-pentyl and n-octyl groups, respectively, are good antibacterial agents against S. typhi and B. subtilis.Keywords: Sulfides, Antibacterial activity, Lipoxygenase activity, Spectral analysi