様々な形態を有するシアン架橋型配位高分子結晶の創製

早大学位記番号:新8181早稲田大

Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors

High fructose feeding causes diet-induced alterations of lipid metabolism and decreased insulin sensitivity, hallmark of which is a rapid and profound hypertriglyceridemia. One of the mechanisms that contribute to serum hypertriglyceridemia in this model is suppression of hepatic PPARα. HMG-CoA inhibitors, which reduce serum triglycerides in these animals, also elevate/restore hepatic PPARα. Previously we demonstrated that two known lipoxygenase/cyclooxygenase inhibitors reversed diet-induced hypertriglyceridemia in this model and that reversal of certain inflammatory markers in the liver correlated with the metabolic benefit. In this paper we extended these studies by examining the impact of these compounds on expression of PPARα, both at the level of transcription and expression. Our data show that diet-induced suppression of hepaic PPARα is reversed upon treatment with lipoxygenase/cyclooxygenase compounds. We then tested one of these compounds, BW-755c, over a range of doses from 10 mg/kg to 100 mg/kg to establish a dose-response relationship with the reduction of serum hypertriglyceridemia in this model. These experiments support the concept of using anti-inflammatory medications as one method to correct metabolic dysfunction

Building information modelling (BIM): now and beyond

Building Information Modeling (BIM), also called n-D Modeling or Virtual Prototyping Technology, is a revolutionary development that is quickly reshaping the Architecture-Engineering-Construction (AEC) industry. BIM is both a technology and a process. The technology component of BIM helps project stakeholders to visualize what is to be built in a simulated environment to identify any potential design, construction or operational issues. The process component enables close collaboration and encourages integration of the roles of all stakeholders on a project. The paper presents an overview of BIM with focus on its core concepts, applications in the project life cycle and benefits for project stakeholders with the help of case studies. The paper also elaborates risks and barriers to BIM implementation and future trends

Adenosine-3′: 5′-Monophosphate-Dependent and Plasma-Membrane-Associated Protein Kinase from Bovine Corpus Luteum

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66089/1/j.1432-1033.1975.tb02354.x.pd

Analisys of Total Economi Value Mangrove Forest Area in Gampong Kuala Langsa, Aceh

Mangrove forest is one of the potential forest resources so that it has a very important role in coastal and marine ecosystems, especially coastal areas. The maintenance and management of mangrove ecosystems is a problem that must be faced together for the sake of the continuity and sustainability of mangrove forests. The purpose of this study was to analyze the magnitude of the potential direct and indirect benefits, the total economic value of the mangrove forest area in the ecotourism development of Langsa City. The analytical method used is the analysis of benefits and costs. For all types of functions and benefits of mangrove forest areas, the total economic value (TEV) is descriptively used. The results showed that the total value of economic benefits from the mangrove forest of Gampong Kuala Langsa, Aceh was Rp. 2.958.847.000,- of the month which was obtained from 1) the direct benefit value from fish, crabs, shrimp, shellfish and seafood processing was amounting to Rp. 213.710.000,- of the month, 2) The value of indirect economic benefits is Rp. 1.014.379.000,- of the month obtained from trading activities and renting boats. 3) The value of choice is Rp. 1.729.038.000, - of the month from biodiversity, 4) The value of being is Rp. 1.720.000, - of the month. There is a surplus of community consumers in their willingness to pay for the existence of mangrove forests of Rp. 2,705,054.12 of the month. Keywords: Total Economic Value; Mangrove Forest; Ecotouris; Kuala Langsa

Cyclic Nucleotide Phosphodiesterases from Rat Anterior Pituitary

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66174/1/j.1432-1033.1977.tb11292.x.pd

The effect of customer relationship management factors on airline customer satisfaction

Airline industry of Pakistan is facing the issue of high passenger turnover, poor infrastructure, ineffectiveness of operations, poor service quality, increasing rate of flight delays and cancellation that leads to passenger’s diffidence. This study investigates mediating effect of corporate image on the relationship between service quality, trust, physical environment, social network interaction, relationship through solving customer problems and customer satisfaction in airline industry of Pakistan. The theories of SET and EDT integrates to explain the relationship between CRM factors, corporate image and customer satisfaction. The data was collected from passengers of PIA, SAI and ABQ, in five airports of Pakistan by using a structured questionnaire and 576 visible responses were analyzed. Using PLS-SEM to analyze the data and test hypotheses, the present study shows that relationship between service quality, trust, physical environment and relationship through solving customer problems were significantly related to corporate image and customer satisfaction. However, the results revealed that social network interaction has shown insignificant relationship with corporate image and customer satisfaction. The findings suggest that mediating effect of corporate image was found significant on the relationship between service quality, trust, physical environment, relationship through solving customer problems and customer satisfaction. Nonetheless, corporate image did not mediate the relationship between social network interaction and customer satisfaction. This study delivers understanding in service marketing area and help airline companies to employ the implementation of role of service quality, customer trust and physical environment, and relationship through solving customer problems as main drivers of customer satisfaction

Editorial

The Architecture, Engineering and Construction (AEC) industries have long sought techniques to decrease project cost, increase productivity and quality, enhance safety, and reduce project delivery time. Building Information Modeling (BIM) offers the potential to achieve these goals. BIM simulates the construction project in a virtual environment. With BIM technology, an accurate virtual model of a facility is digitally constructed. When completed, the computer-generated model contains precise geometry and relevant data needed to support the programming, fabrication, procurement, construction, and post-construction activities. It can be used by project stakeholders for planning and decision making throughout the project life cycle. BIM represents a new paradigm within AEC, one that encourages integration of the roles of all stakeholders on a project. It has the potential to promote greater efficiency and harmony among players who, in the past, saw themselves as adversaries

Consequences of over-expression of rat Scavenger Receptor, SR-BI, in an adrenal cell model

BACKGROUND: The plasma membrane scavenger receptor, SR-BI, mediates the 'selective uptake' process by which cholesteryl esters (CE) from exogenously supplied HDL are taken up by target cells. Recent work suggests that dimer and higher order oligomeric forms of the SR-BI protein are important to this process. SR-BI has been shown to be particularly associated with microvilli and microvillar channels found at the cell surface of steroidogenic cells, and a study with the hormone stimulated adrenal gland has shown impressive changes in the size and complexity of the microvillar compartment as the mass of CE uptake (and accompanying steroidogenesis) fluctuates. In the present study, we examine a cell line in which we overexpress the SR-BI protein to determine if morphological, biochemical and functional events associated with SR-BI in a controlled cell system are similar to those observed in the intact mammalian adrenal which is responsive to systemic factors. METHODS: Y1-BS1 mouse adrenocortical cells were transiently transfected using rat SR-BI-pcDNA6-V5-His, rat SR-BI-pcDNA6-cMyc-His or control pcDNA6-V5-His vector construct using a CaPO(4 )precipitation technique. Twenty four hours after transfection, cells were treated with, or without, Bt(2)cAMP, and SR-BI expression, CE uptake, and steroidogenesis was measured. SR-BI dimerization and cell surface architectural changes were assessed using immunoelectron microscopic techniques. RESULTS: Overexpression of the scavenger receptor protein, SR-BI, in Y1-BS1 cells results in major alterations in cell surface architecture designed to increase uptake of HDL supplied-CEs. Changes include [1] the formation of crater-like erosions of the surface with multiple double membraned channel structures lining the craters, and [2] dimerized formations of SR-BI lining the newly formed craters and associated double membraned channels. CONCLUSION: These data show that overexpression of the scavenger receptor protein, SR-BI (accompanied by suitable hormone treatment and lipoproteins) in susceptible mammalian cells – is associated with increased cholesterol uptake and SR-BI dimerization within a much enlarged and architecturally complex microvillar compartment. These changes duplicate the structural, biochemical and functional changes related to the uptake of HDL CEs normally signaled by the action of ACTH on intact adrenal tissue

Sickness in Small-Scale Industries in South Punjab: Hurdles & Remedies: A Study of Bahawalpur Estate Area, Pakistan

This study was based on in-depth exploratory investigation of Bahawalpur (Pakistan) industrial estate area to find out the internal and external root causes of sickness in small industries and their solutions. Ashraf et al.(2012) noticed reasons of meager performance of small firms as lack of managerial knowledge, high rate of interest on loans, heavy taxation,  poor government policies, owner’s education level and use of outdated technology, that’s why the most of small units have poor success and growth.  Shukla (1993) and Reddy et al. (1988) found the causes of sickness in Small Scale industry which  were generally related to production, finance, environmental,  management and  marketing  factors.  Collection of data was executed through both primary and secondary sources. Both qualitative and quantitative research methods had been used for the study. Data was primarily collected through structured questionnaires as well as interviews of owners/managers of small industrial units at Bahawalpur industrial estate area. SPSS software was used to analyze the data.  In this study we found that 76.9% units were facing energy crisis and almost all the units were also facing high Mark-up problem and Inflation problem. Other obstructions that units were facing comprising the high level of taxation, lack of education, difficulty in accessing credit, lack of market information, lack of management skills etc. which leads to low level of production and unemployment etc. Keywords: Industrial obstructions, Remedies, low productio