Common coeliacomesenteric trunk: a computed tomography radiological study

Background: There is an increasing trend for administration of invasive radiological interventions, laparoscopic surgery, and transplantation procedures in recent years, and determining the vascular variations prior to these procedures is crucially important. Coeliacomesenteric trunk (CMT) is among these variations. This study aimed to retrospectively evaluate this rare anomaly by computed tomography (CT). Materials and methods: A total of 1000 CT angiography images were analysed retrospectively, and the patients with mesenteric and coeliac arteries arising from the abdominal aorta with a single root were identified. The level that CMT arose, and its branching patterns were determined individually for all patients. Results: Ten patients (6 males and 4 females) with a mean age of 50.2 years (17–87 years) had CMT in CT images. Conclusions: The knowledge of variations in the CMT prior to vascular or laparoscopic interventions will contribute to early intervention in case of a complication, or to avoid from a potential damage

Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience

Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population.Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed.Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%).Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC.Turkish Association for the Study of The Liver (TASL

Congenital Diarrhea and Cholestatic Liver Disease: Phenotypic Spectrum Associated with MYO5B Mutations.

Myosin Vb (MYO5B) is a motor protein that facilitates protein trafficking and recycling in polarized cells by RAB11- and RAB8-dependent mechanisms. Biallelic MYO5B mutations are identified in the majority of patients with microvillus inclusion disease (MVID). MVID is an intractable diarrhea of infantile onset with characteristic histopathologic findings that requires life-long parenteral nutrition or intestinal transplantation. A large number of such patients eventually develop cholestatic liver disease. Bi-allelic MYO5B mutations are also identified in a subset of patients with predominant early-onset cholestatic liver disease. We present here the compilation of 114 patients with disease-causing MYO5B genotypes, including 44 novel patients as well as 35 novel MYO5B mutations, and an analysis of MYO5B mutations with regard to functional consequences. Our data support the concept that (1) a complete lack of MYO5B protein or early MYO5B truncation causes predominant intestinal disease (MYO5B-MVID), (2) the expression of full-length mutant MYO5B proteins with residual function causes predominant cholestatic liver disease (MYO5B-PFIC), and (3) the expression of mutant MYO5B proteins without residual function causes both intestinal and hepatic disease (MYO5B-MIXED). Genotype-phenotype data are deposited in the existing open MYO5B database in order to improve disease diagnosis, prognosis, and genetic counseling

Evaluation of newborn mothers’ status of bonding to the baby, experiencing depression, and associated factors [Doğum Yapan Annelerin Bebeklerine Bağlanma ve Depresyon Yaşama Durumları ile Etkileyen Faktörlerin İncelenmesi]

Objective: The aim of this study is to evaluate newly delivered mothers’ status of bonding to their babies, their status of experiencing depression following delivery.and associated factors. Methods: The study was descriptive and sectional-type; and performed in a public hospital between February 1 and April 1 2015. Sample of the study was composed of 150 women who approved to participate in the study during this time interval. Participant information form. Mother to Infant Bonding Scale and Edinburgh Postnatal Depression Scale were used as data collection tools. Data were collected by face-to-face interview technique. Kruskal Wallis. Mann-Whitney U, student-t test and correlation analysis were used for statistical analysis of the data. Results: It was found that mean score of women from mother-to-infant bonding scale was 1.13±1.81.mean score from depression scale was 8.12±4.85 and 16.7% of the women were within the risk group for depression. A statistically significant difference was detected between mother to infant bonding status of women in the study and their status of willingness at last pregnancy (p0.05). There was a significant difference between women’s status of getting support from their spouses during the pregnancy and experiencing depression (p<0.05) (p=0.03). It was found that there was a positive and weak correlation between women’s status of experiencing depression and the level of mother-to-infant bonding; and the level of mother to infant bonding increased as the level of depression increased (p=0.09, r=0.21). Conclusion: Mother to infant bonding rates of the women in the study were found to be high; and it was determined that eager pregnancy strengthened the bond between the mother and the baby, support taken from the spouse during pregnancy affected the level of depression, and the level of mother-to-infant bonding increased as the level of depression increased. © 2019 Galenos Publishing House. All rights reserved

Role of different bleaching earths for sunfl ower oil in a pilot plant bleaching system

The purpose of present study is to investigate the effi ciency of different kinds of Turkish commercial bleaching earth materials for changes in different colour pigment concentrations in neutralized sunfl ower oils. The bleaching experiments were performed in a pilot system under at stable vacuum (50 mmHg) and temperature (100°C) for 30 min. By examining the changes in chlorophyll, ?-carotene and red colour, bleaching process parameters such as type and dosage of the bleaching material were optimised. The sorption characteristics of colour pigments were evaluated using common adsorption isotherms and Scatchard plot analysis. Ads-3 acid-activated earth material at 1% (w/w) per samples was found to be the most appropriate sorbent and the amount of sorbed pigments was calculated as 1.01x10-4 mmol/g ads. for chlorophyll, 1.15×10-3 mmol/g ads. for carotene and 1.70 red on Lovibond colour scale. The procedure indicated that this system can be easily adapted to the actual oil refi ning systems.3060009The  authors are grateful for kind financial support provided by The Scientific and Technological Research Council of Turkey (TUBITAK) in Technology and Innovation Funding Programs Directorate (TEYDEB), Project Number: 3060009. The  authors thank to Helvacızade Edible Oil Company for administrative support and guidance