5 research outputs found
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Intercultural Conflict and Peace Building: The Experience of Chile
With nine distinct Indigenous Peoples and a population of 1.8 million, which represents 11% of the total population of the country,1 conflicts between Indigenous Peoples and the Chilean state have increased substantially in recent years. Such conflicts have been triggered by different factors including the lack of constitutional recognition of Indigenous Peoples; political exclusion; and the imposition of an economic model which has resulted in the proliferation of large developments on Indigenous lands and territories without proper consultation, even less with free, prior, and informed consent, and with no participation of the communities directly affected by the benefits these developments generate. The growing awareness among Indigenous Peoples of the rights that have been internationally recognized to them, and the lack of government response to their claims—in particular land claims—also help to explain this growing conflict
Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors
Context
Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).
Objective
To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.
Design
12-year prospective, observational study.
Participants & Setting
We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases.
Interventions & Outcome
AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310).
Results
Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650).
Conclusions
Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course
DesafĂos de la conservaciĂłn en los territorios indĂgenas en Chile
Estos trabajos han sido elaborados por el Observatorio Ciudadano en el contexto del proyecto “Desarrollo de estrategias de autonomĂa y control ciudadano para la gestiĂłn descentralizada de áreas silvestres protegidas del estado en la regiĂłn de La AraucanĂa de Chile y la provincia de NeuquĂ©n de Argentina”, impulsado por el Observatorio Ciudadano, La ConfederaciĂłn Mapuche de NeuquĂ©n, Pro Patagonia y CET Sur, con el apoyo de IDRC de Canadá.No se ha podido determinar el nĂşmero de proyecto relativo al apoyo financiero del CII