Neopterin and Soluble Urokinase Type Plasminogen Activator Receptor as Biomarkers in Dogs with Systemic Inflammatory Response Syndrome

ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΛΗΨΗThe systemic inflammatory response syndrome (SIRS) is a common cause of mortality in dogs. This study aims to investigate the diagnostic value of markers C-reactive protein (CRP), soluble urokinase-type plasminogen activator receptor (suPAR) and neopterin in dogs with SIRS. The materials of the study consist of 30 dogs with SIRS and 15 healthy dogs that show no clinical symptom, 45 dogs in total. CRP, suPAR and neopterin levels of the serum samples were determined by ELISA using commercial kits. In the study, it was found that CRP, suPAR and neopterin levels of dogs with SIRS were significantly higher (P < 0.001, P < 0.01 and P < 0.01, respectively) than those in the healthy group. The cut-off values for the healthy dogs and dogs with SIRS for CRP, suPAR and neopterin were determined to be 11.20 mg/L, 223.68 ng/L and 3.23 nmol/mL, respectively. At these cut-off values, sensitivity levels were determined as high (92.90%) for CRP, moderate (63.30%) for neopterin, and low (53.30%) for suPAR, and high specificities (93.30%) were determined for all. In conclusion, it was determined that CRP showed the best performance for the detection of systemic inflammatory response in dogs and neopterin and suPAR could be used as an alternative to CRP. It was also argued that further studies were necessary in order to determine diagnosis and prognosis of diseases

Data assimilation using adaptive, non-conservative, moving mesh models

Numerical models solved on adaptive moving meshes have become increasingly prevalent in recent years. Motivating problems include the study of fluids in a Lagrangian frame and the presence of highly localized structures such as shock waves or interfaces. In the former case, Lagrangian solvers move the nodes of the mesh with the dynamical flow; in the latter, mesh resolution is increased in the proximity of the localized structure. Mesh adaptation can include remeshing, a procedure that adds or removes mesh nodes according to specific rules reflecting constraints in the numerical solver. In this case, the number of mesh nodes will change during the integration and, as a result, the dimension of the model's state vector will not be conserved. This work presents a novel approach to the formulation of ensemble data assimilation (DA) for models with this underlying computational structure. The challenge lies in the fact that remeshing entails a different state space dimension across members of the ensemble, thus impeding the usual computation of consistent ensemble-based statistics. Our methodology adds one forward and one backward mapping step before and after the ensemble Kalman filter (EnKF) analysis, respectively. This mapping takes all the ensemble members onto a fixed, uniform reference mesh where the EnKF analysis can be performed. We consider a high-resolution (HR) and a low-resolution (LR) fixed uniform reference mesh, whose resolutions are determined by the remeshing tolerances. This way the reference meshes embed the model numerical constraints and are also upper and lower uniform meshes bounding the resolutions of the individual ensemble meshes. Numerical experiments are carried out using 1-D prototypical models: Burgers and Kuramoto-Sivashinsky equations and both Eulerian and Lagrangian synthetic observations. While the HR strategy generally outperforms that of LR, their skill difference can be reduced substantially by an optimal tuning of the data assimilation parameters. The LR case is appealing in high dimensions because of its lower computational burden. Lagrangian observations are shown to be very effective in that fewer of them are able to keep the analysis error at a level comparable to the more numerous observers for the Eulerian case. This study is motivated by the development of suitable EnKF strategies for 2-D models of the sea ice that are numerically solved on a Lagrangian mesh with remeshing

Axial-flexural coupled vibration and buckling of composite beams using sinusoidal shear deformation theory

A finite element model based on sinusoidal shear deformation theory is developed to study vibration and buckling analysis of composite beams with arbitrary lay-ups. This theory satisfies the zero traction boundary conditions on the top and bottom surfaces of beam without using shear correction factors. Besides, it has strong similarity with Euler–Bernoulli beam theory in some aspects such as governing equations, boundary conditions, and stress resultant expressions. By using Hamilton’s principle, governing equations of motion are derived. A displacement-based one-dimensional finite element model is developed to solve the problem. Numerical results for cross-ply and angle-ply composite beams are obtained as special cases and are compared with other solutions available in the literature. A variety of parametric studies are conducted to demonstrate the effect of fiber orientation and modulus ratio on the natural frequencies, critical buckling loads, and load-frequency curves as well as corresponding mode shapes of composite beams

Bergmann-Thomson energy-momentum complex for solutions more general than the Kerr-Schild class

In a very well-known paper, Virbhadra's research group proved that the Weinberg, Papapetrou, Landau and Lifshitz, and Einstein energy-momentum complexes ``coincide'' for all metrics of Kerr-Schild class. A few years later, Virbhadra clarified that this ``coincidence'' in fact holds for metrics more general than the Kerr-Schild class. In the present paper, this study is extended for the Bergmann-Thomson complex and it is proved that this complex also ``coincides'' with those complexes for a more general than the Kerr-Schild class metric.Comment: RevTex, 12 page

Teleparallel Energy-Momentum Distribution of Static Axially Symmetric Spacetimes

This paper is devoted to discuss the energy-momentum for static axially symmetric spacetimes in the framework of teleparallel theory of gravity. For this purpose, we use the teleparallel versions of Einstein, Landau-Lifshitz, Bergmann and M$\ddot{o}$ller prescriptions. A comparison of the results shows that the energy density is different but the momentum turns out to be constant in each prescription. This is exactly similar to the results available in literature using the framework of General Relativity. It is mentioned here that M$\ddot{o}$ller energy-momentum distribution is independent of the coupling constant $\lambda$. Finally, we calculate energy-momentum distribution for the Curzon metric, a special case of the above mentioned spacetime.Comment: 14 pages, accepted for publication in Mod. Phys. Lett.

Energy and Momentum Distributions of Kantowski and Sachs Space-time

We use the Einstein, Bergmann-Thomson, Landau-Lifshitz and Papapetrou energy-momentum complexes to calculate the energy and momentum distributions of Kantowski and Sachs space-time. We show that the Einstein and Bergmann-Thomson definitions furnish a consistent result for the energy distribution, but the definition of Landau-Lifshitz do not agree with them. We show that a signature switch should affect about everything including energy distribution in the case of Einstein and Papapetrou prescriptions but not in Bergmann-Thomson and Landau-Lifshitz prescriptions.Comment: 12 page

Teleparallel Energy-Momentum Distribution of Spatially Homogeneous Rotating Spacetimes

The energy-momentum distribution of spatially homogeneous rotating spacetimes in the context of teleparallel theory of gravity is investigated. For this purpose, we use the teleparallel version of Moller prescription. It is found that the components of energy-momentum density are finite and well-defined but are different from General Relativity. However, the energy-momentum density components become the same in both theories under certain assumptions. We also analyse these quantities for some special solutions of the spatially homogeneous rotating spacetimes.Comment: 12 pages, accepted for publication in Int. J. Theor. Phy

Static and vibration analysis of functionally graded beams using refined shear deformation theory

Static and vibration analysis of functionally graded beams using refined shear deformation theory is presented. The developed theory, which does not require shear correction factor, accounts for shear deformation effect and coupling coming from the material anisotropy. Governing equations of motion are derived from the Hamilton's principle. The resulting coupling is referred to as triply coupled axial-flexural response. A two-noded Hermite-cubic element with five degree-of-freedom per node is developed to solve the problem. Numerical results are obtained for functionally graded beams with simply-supported, cantilever-free and clamped-clamped boundary conditions to investigate effects of the power-law exponent and modulus ratio on the displacements, natural frequencies and corresponding mode shapes

The averaged tensors of the relative energy-momentum and angular momentum in general relativity and some their applications

There exist at least a few different kind of averaging of the differences of the energy-momentum and angular momentum in normal coordinates {\bf NC(P)} which give tensorial quantities. The obtained averaged quantities are equivalent mathematically because they differ only by constant scalar dimensional factors. One of these averaging was used in our papers [1-8] giving the {\it canonical superenergy and angular supermomentum tensors}. In this paper we present another averaging of the differences of the energy-momentum and angular momentum which gives tensorial quantities with proper dimensions of the energy-momentum and angular momentum densities. But these averaged relative energy-momentum and angular momentum tensors, closely related to the canonical superenergy and angular supermomentum tensors, {\it depend on some fundamental length $L>0$}. The averaged relative energy-momentum and angular momentum tensors of the gravitational field obtained in the paper can be applied, like the canonical superenergy and angular supermomentum tensors, to {\it coordinate independent} analysis (local and in special cases also global) of this field. We have applied the averaged relative energy-momentum tensors to analyze vacuum gravitational energy and momentum and to analyze energy and momentum of the Friedman (and also more general) universes. The obtained results are very interesting, e.g., the averaged relative energy density is {\it positive definite} for the all Friedman universes.Comment: 30 pages, minor changes referring to Kasner universe