A Generalized Framework on Beamformer Design and CSI Acquisition for Single-Carrier Massive MIMO Systems in Millimeter Wave Channels

In this paper, we establish a general framework on the reduced dimensional channel state information (CSI) estimation and pre-beamformer design for frequency-selective massive multiple-input multiple-output MIMO systems employing single-carrier (SC) modulation in time division duplex (TDD) mode by exploiting the joint angle-delay domain channel sparsity in millimeter (mm) wave frequencies. First, based on a generic subspace projection taking the joint angle-delay power profile and user-grouping into account, the reduced rank minimum mean square error (RR-MMSE) instantaneous CSI estimator is derived for spatially correlated wideband MIMO channels. Second, the statistical pre-beamformer design is considered for frequency-selective SC massive MIMO channels. We examine the dimension reduction problem and subspace (beamspace) construction on which the RR-MMSE estimation can be realized as accurately as possible. Finally, a spatio-temporal domain correlator type reduced rank channel estimator, as an approximation of the RR-MMSE estimate, is obtained by carrying out least square (LS) estimation in a proper reduced dimensional beamspace. It is observed that the proposed techniques show remarkable robustness to the pilot interference (or contamination) with a significant reduction in pilot overhead

Beamspace Aware Adaptive Channel Estimation for Single-Carrier Time-varying Massive MIMO Channels

In this paper, the problem of sequential beam construction and adaptive channel estimation based on reduced rank (RR) Kalman filtering for frequency-selective massive multiple-input multiple-output (MIMO) systems employing single-carrier (SC) in time division duplex (TDD) mode are considered. In two-stage beamforming, a new algorithm for statistical pre-beamformer design is proposed for spatially correlated time-varying wideband MIMO channels under the assumption that the channel is a stationary Gauss-Markov random process. The proposed algorithm yields a nearly optimal pre-beamformer whose beam pattern is designed sequentially with low complexity by taking the user-grouping into account, and exploiting the properties of Kalman filtering and associated prediction error covariance matrices. The resulting design, based on the second order statistical properties of the channel, generates beamspace on which the RR Kalman estimator can be realized as accurately as possible. It is observed that the adaptive channel estimation technique together with the proposed sequential beamspace construction shows remarkable robustness to the pilot interference. This comes with significant reduction in both pilot overhead and dimension of the pre-beamformer lowering both hardware complexity and power consumption.Comment: 7 pages, 3 figures, accepted by IEEE ICC 2017 Wireless Communications Symposiu

Human-robot interaction: Exploring the ability to express emotions by a social robot

Robots should have characteristics that make the interaction effective and fluent for a successful Human-Robot Interaction (HRI). Since the emotions play a fundamental role in the human interaction process, many robots are introduced facial expressions, speech, body movements, among others to deepen the HRI. This chapter presents the exploration, design, and evaluation of the recognition of emotions displayed by a social robot. Initially, a pre-experiment was done to program the emotions in a virtual prototype. Afterwards, a pilot study and two experiments were conducted by manipulating the robot facial expressions and body movements to evaluate the recognition of the emotions. The results show that joy, surprise, and sadness have higher correct recognition and fear, disgust, and anger reported as lower recognition. Further study is needed regarding body movement and displacement of the robot for disgust, fear, and anger. Moreover, a robot should be introduced in a specific context to increase the recognition of emotions.info:eu-repo/semantics/acceptedVersio

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

SummaryWhether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut mucosa is controversial and few studies have analyzed specific cell populations for protective functions within the inflamed colonic tissue. Here we have provided evidence for IL-17A-dependent regulation of the tight junction protein occludin during epithelial injury that limits excessive permeability and maintains barrier integrity. Analysis of epithelial cells showed that in the absence of signaling via the IL-17 receptor adaptor protein Act-1, the protective effect of IL-17A was abrogated and inflammation was enhanced. We have demonstrated that after acute intestinal injury, IL-23R+ γδ T cells in the colonic lamina propria were the primary producers of early, gut-protective IL-17A, and this production of IL-17A was IL-23 independent, leaving protective IL-17 intact in the absence of IL-23. These results suggest that IL-17-producing γδ T cells are important for the maintenance and protection of epithelial barriers in the intestinal mucosa

Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

Background: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown. Methods: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical events. Results: Infants (n=5609) born at mean (standard deviation [SD]) 36.2 (4.4) weeks postmenstrual age (35.7% preterm) underwent 6542 procedures within 63 (48) days of birth. Critical event(s) requiring intervention occurred in 35.2% of cases, mainly hypotension (>30% decrease in blood pressure) or reduced oxygenation (SpO2 <85%). Postmenstrual age influenced the incidence and thresholds for intervention. Risk of critical events was increased by prior neonatal medical conditions, congenital anomalies, or both (relative risk [RR]=1.16; 95% confidence interval [CI], 1.04–1.28) and in those requiring preoperative intensive support (RR=1.27; 95% CI, 1.15–1.41). Additional complications occurred in 16.3% of patients by 30 days, and overall 90-day mortality was 3.2% (95% CI, 2.7–3.7%). Co-occurrence of intraoperative hypotension, hypoxaemia, and anaemia was associated with increased risk of morbidity (RR=3.56; 95% CI, 1.64–7.71) and mortality (RR=19.80; 95% CI, 5.87–66.7). Conclusions: Variability in physiological thresholds that triggered an intervention, and the impact of poor tissue oxygenation on patient's outcome, highlight the need for more standardised perioperative management guidelines for neonates and infants. Clinical trial registration: NCT02350348

Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Background: Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences. Methods: We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children audiT of Anaesthesia pRactice IN Europe [NECTARINE]) in neonates and small infants with difficult tracheal intubation. The primary endpoint was the incidence of difficult intubation and the related complications. The secondary endpoints were the risk factors for severe hypoxaemia attributed to difficult airway management, and 30 and 90 day outcomes. Results: Tracheal intubation was planned in 4683 procedures. Difficult tracheal intubation, defined as two failed attempts of direct laryngoscopy, occurred in 266 children (271 procedures) with an incidence (95% confidence interval [CI]) of 5.8% (95% CI, 5.1e6.5). Bradycardia occurred in 8% of the cases with difficult intubation, whereas a significant decrease in oxygen saturation (SpO2<90% for 60 s) was reported in 40%. No associated risk factors could be identified among comorbidities, surgical, or anaesthesia management. Using propensity scoring to adjust for confounders, difficult anaesthesia tracheal intubation did not lead to an increase in 30 and 90 day morbidity or mortality. Conclusions: The results of the present study demonstrate a high incidence of difficult tracheal intubation in children less than 60 weeks post-conceptual age commonly resulting in severe hypoxaemia. Reassuringly, the morbidity and mortality at 30 and 90 days was not increased by the occurrence of a difficult intubation event. Clinical trial registration: NCT02350348

Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

BACKGROUND: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown. METHODS: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical events. RESULTS: Infants (n=5609) born at mean (standard deviation [sd]) 36.2 (4.4) weeks postmenstrual age (35.7% preterm) underwent 6542 procedures within 63 (48) days of birth. Critical event(s) requiring intervention occurred in 35.2% of cases, mainly hypotension (>30% decrease in blood pressure) or reduced oxygenation (SpO2 <85%). Postmenstrual age influenced the incidence and thresholds for intervention. Risk of critical events was increased by prior neonatal medical conditions, congenital anomalies, or both (relative risk [RR]=1.16; 95% confidence interval [CI], 1.04–1.28) and in those requiring preoperative intensive support (RR=1.27; 95% CI, 1.15–1.41). Additional complications occurred in 16.3% of patients by 30 days, and overall 90-day mortality was 3.2% (95% CI, 2.7–3.7%). Co-occurrence of intraoperative hypotension, hypoxaemia, and anaemia was associated with increased risk of morbidity (RR=3.56; 95% CI, 1.64–7.71) and mortality (RR=19.80; 95% CI, 5.87–66.7). CONCLUSIONS: Variability in physiological thresholds that triggered an intervention, and the impact of poor tissue oxygenation on patient's outcome, highlight the need for more standardised perioperative management guidelines for neonates and infants