Radiation Safety Procedures For Non-Radiation Workers in Case of Application Radionuclide Therapy in the Dialysis Patients

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Comparison of the accuracy of isosulfan blue and technetium -99m lymphoscintigraphy to determine axillary node metastasis in breast cancer.

This study aimed to compare the efficiency of isosulfan blue (ISB) and colloid methods in determining metastatic conditions of axillary lymph node in sentinel lymph node biopsy (SLNB). This prospective study was performed between April 2005 and July 2009 at Gulhane Medical Faculty, Department of General Surgery. A total of 102 female patients diagnosed with breast cancer were enrolled in the clinic of Gulhane School of Medicine. According to the diagnostic protocols of SLN, the patients were divided into three groups as follows: ISB (group I), colloid (group II), and ISB and colloid (group III). SLN was identified in 49 of 52 patients (94.2%) in the ISB group; the sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and false negativity (FN) ratio were found to be 90.9%, 75.8%, 96.1%, 55.5%, and 9.1%, respectively. On the contrary, the sentinel lymph node was identified in 38 of 38 (100%) patients in the colloid group; the sensitivity, specificity, PPV, NPV, and FN were found to be 88.2%, 100%, 100%, 91.3%, and 11.8%, respectively. In ISB and colloid groups; SLN was identified in 12 of 12 (100%) patients in the ISB and colloid groups; the sensitivity, specificity, PPV, NPV, and FN were found to be 100%, 100%, 100%, and 0%, respectively. This study showed that the combined methods applied to heterogeneous groups of patients for SLNB in breast cancer cases were minimally invasive and effective and hence could be used for evaluating nodal metastases

Effects of low and high doses of atorvastatin on arterial compliance

At the beginning of atherosclerosis before evidence of morphological lesions or plaques, vascular distensibility or arterial compliance decreased gradually. This endothelial dysfunction is regarded as art early feature of atherosclerosis. In a randomized, double-blind study design, group I (12 patients; 7 males, 5 females) with serum LDL-C levels higher than 170 mg/dL and without any other risk factor for atherosclerosis received three months of 20 mg/day atorvastatin treatment while group II (8 males, 4 females) with the same characteristics received 80 mg/day. Baseline and posttreatment serum lipid fractions and arterial compliance were measured. Arterial compliance was measured noninvasively in the left common carotid artery with color Doppler ultrasound. Atorvastatin reduced total cholesterol (TC), LDL-C, and triglyceride levels by 32% (P < 0.001). 40.8% (P < 0.001), and 19% (P < 0.001), respectively, and increased HDL-C by 6.9% (P = 0.002) in the first group. In the second group these reductions were 33.5% (P < 0.001), 46.2% (P < 0.001), and 26.78% (P < 0.001), respectively, and the increase in HDL was 7.8% (P = 0.03). It was observed that the decrease in serum TC. LDL-C and triglyceride levels were significantly higher in the second group than the first group. With atorvastatin, the distensibility coefficient (DC) and compliance coefficient (CC) increased front 18.7 +/- 3.14 to 21.3 +/- 2.9 10(-3).kPa(-1) (P < 0.001) and from 0.69 +/- 0.05 to 0.77 +/- 0.03 mm(2).kPa(-1) (P < 0.001) in the first group while they changed from 18.3 +/- 3.6 to 21.9 +/- 3.0 10(-3).kPa(-1) (P < 0.001) and from 0.70 +/- 0.04 to 0.81 +/- 0.01 mm(2).kPa(-1) (P < 0.001) respectively, in the second group. DC and CC increased in both groups, but the differences between the groups were not significant. High doses of atorvastatin reduce blood lipid levels more than conventional doses, however, the change in compliance is not dose-dependent. As endothelial dysfunction is regarded as an early feature of atherosclerosis, there would be no need to administer aggressive doses in a patient without any risk factors other than hyperlipidemia

Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT

Background. The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response

Substernal goiter: A case report

Substernal guatr, göğüs boşluğu içinde yer kaplayıcı niteliğe sahip olan ve primer mediasten orjinli olabileceği gibi, büyük çoğunlukla servikal guatrın büyüyerek üst mediastinuma uzanım göstermesiyle de oluşabilen ve bası semptomlarına yol açabilen bir tiroit bezi patolojisidir. Bu çalışmada acil servise nefes darlığı ile gelen ve substernal guatr tespit edilen 76 yaşında bayan hasta sunularak Tip 2 solunum yetmezliğinin nadir gözlenen bu sebebine dikkat çekilmek istenmiştir. Hastanın tiroit bezi iki taraflı palpabl olup, kan gazında hiperkarbisi olan hastaya tip 2 solunum yetmezliği tanısı konulduSubsternal goiter is a thyroid gland disorder that would occupy within the chest cavity and would origin from the mediastinal space, mostly occurs as cervical goiter growth in the upper mediastinum and can lead to symptoms of compressing. In this study, we are presenting a case, who 76-year-old female has come to the emergency department with shortness of breath and substernal goiter, purposing to draw attention to this rare cause of type 2 respiratory failure. The thyroid gland was palpable (bilateral +2) in the patient. In the patient blood gas, hypercarbia was detected and the patient was diagnosed with type 2 respiratory failure

Substernal goiter: A case report

Substernal guatr, göğüs boşluğu içinde yer kaplayıcı niteliğe sahip olan ve primer mediasten orjinli olabileceği gibi, büyük çoğunlukla servikal guatrın büyüyerek üst mediastinuma uzanım göstermesiyle de oluşabilen ve bası semptomlarına yol açabilen bir tiroit bezi patolojisidir. Bu çalışmada acil servise nefes darlığı ile gelen ve substernal guatr tespit edilen 76 yaşında bayan hasta sunularak Tip 2 solunum yetmezliğinin nadir gözlenen bu sebebine dikkat çekilmek istenmiştir. Hastanın tiroit bezi iki taraflı palpabl olup, kan gazında hiperkarbisi olan hastaya tip 2 solunum yetmezliği tanısı konulduSubsternal goiter is a thyroid gland disorder that would occupy within the chest cavity and would origin from the mediastinal space, mostly occurs as cervical goiter growth in the upper mediastinum and can lead to symptoms of compressing. In this study, we are presenting a case, who 76-year-old female has come to the emergency department with shortness of breath and substernal goiter, purposing to draw attention to this rare cause of type 2 respiratory failure. The thyroid gland was palpable (bilateral +2) in the patient. In the patient blood gas, hypercarbia was detected and the patient was diagnosed with type 2 respiratory failure