New acoustic respiratory sound monitoring with artificial intelligence

Monitored anesthesia care (MAC) often causes airway complications, particularly posing an elevated risk of aspiration and airway obstruction in obese patients. This study aimed to quantify the levels of aspiration and airway obstruction using an artificial intelligence (AI)-based acoustic analysis algorithm, assessing its utility in identifying airway complications in obese patients. To verify the correlation between the stridor quantitative value (STQV) calculated by acoustic analysis and body weight, and to further evaluate fluid retention and airway obstruction, STQV calculated exhaled breath sounds collected at the neck region, was compared before and after injection of 3 ml of water in the oral cavity and at the start and end of the MAC procedures. STQV measured immediately following the initiation of MAC exhibited a weak correlation with body mass index. Furhtermore, STQV values before and after water injection increased predominantly after injection, further increased at the end of MAC. AI-based analysis of cervical respiratory sounds can enhance the safety of airway management during MAC by quantifying airway obstruction and fluid retention in obese patients

An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants

As long as the coronavirus disease-2019 (COVID-19) pandemic continues, new variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with altered antigenicity will emerge. The development of vaccines that elicit robust, broad, and durable protection against SARS-CoV-2 variants is urgently required. We have developed a vaccine consisting of the attenuated vaccinia virus Dairen-I (DIs) strain platform carrying the SARS-CoV-2 S gene (rDIs-S). rDIs-S induced neutralizing antibody and T-lymphocyte responses in cynomolgus macaques and human angiotensin-converting enzyme 2 (hACE2) transgenic mice, and the mouse model showed broad protection against SARS-CoV-2 isolates ranging from the early-pandemic strain (WK-521) to the recent Omicron BA.1 variant (TY38-873). Using a tandem mass tag (TMT)-based quantitative proteomic analysis of lung homogenates from hACE2 transgenic mice, we found that, among mice subjected to challenge infection with WK-521, vaccination with rDIs-S prevented protein expression related to the severe pathogenic effects of SARS-CoV-2 infection (tissue destruction, inflammation, coagulation, fibrosis, and angiogenesis) and restored protein expression related to immune responses (antigen presentation and cellular response to stress). Furthermore, long-term studies in mice showed that vaccination with rDIs-S maintains S protein-specific antibody titers for at least 6 months after a first vaccination. Thus, rDIs-S appears to provide broad and durable protective immunity against SARS-CoV-2, including current variants such as Omicron BA.1 and possibly future variants

Flow Characteristics of Drag-Reducing Surfactant Solutions

The objective of this study is to clarify the flow characteristics of drag-reducing flow and to elucidate the mechanism underlying this phenomenon. The surfactant and counter ion we used were Lipothoquad O/12 and sodium salicylate, respectively. The drag reduction rate (DR%) was measured by using a recirculating system with a diameter of 25.6 mm. We also measured the flow characteristics of the surfactant solutions with different concentrations and temperatures by using particle image velocimetry (PIV). From the experimental results, DR% at an average velocity of 2.0 m/s increased from 0 to 68% as the temperature increased from 10 to 40 °C at a constant concentration of surfactant (300 mg/L). From the velocity contour plot obtained from PIV, we found that the thickness of the lower-velocity region of the drag-reducing flow near the pipe wall was thick at 20 °C, whereas vortex motions seemed controlled at 30 °C. On the other hand, the lower-velocity region thickened as the concentration of the surfactant increased at 25°C. Even if the same level of drag-reducing effects occurred, the flow patterns were quite different depending on the concentration and temperature

Preparation and Rheology of Magnetorheological Fluid Using Six Kinds of Fumed Silica as Stabilizing Additives

In this study, magnetorheological fluid (MRF) was prepared with several kinds of hydrophobic fumed silica in order to improve MRF stability while maintaining desirable fluidity. We conducted steady flow measurements and oil separation tests under gravity and centrifugal conditions. The linkage of fumed silica particles was also observed morphologically by transmission electron microscopy. We found that the MRF sedimentation stability correlated with viscosity in the lower shear rate range. The oil separation ratio improved with the addition of the fumed silicas examined in this study. The surface characteristics of the silica particles affected the stabilization ability. The addition of hydrophobic fumed silica can desirably increase MRF magnetic properties

Preparation of Magnetorheological Fluid Using Stabilizing Additives

In this study, we examined three kinds of stabilizing additives to prepare stable MRF with good fluidity. We selected three stabilizing additives; a styrene isoprene block copolymer, a hydrophobic fumed silica, and an organogelator (CMOL SB03; PMDA-2C8/oleyl). We measured the rheological properties both for the dissolutions of the stabilizing additives in the base oil and MRFs prepared with the additives by using a rheometer; MCR302 (Anton Paar Corp.). From the experimental results, the viscosity of styrene isoprene block copolymer dissolution increased with concentration showing non-Newtonian properties. We selected a suitable concentration as 5wt% to satisfied good fluidity without forming gel. Since the viscosities of 7wt% fumed silica and 1wt% CMOL SB 03 dissolutions in the base oil consequently showed similar viscosity of the 5wt% copolymer, MRFs using such conditions were prepared. From the results of the stability test, the addition of the copolymer was effective to satisfy the stability of the MRF. We also found that the addition of such stabilizing additives were effective to increase the magnetic property of MRFs