Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study

PURPOSEThe clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions.METHODSThis retrospective multicenter analysis included 1.343 patients diagnosed with high-risk lesions using an image-guided core needle or vacuum-assisted biopsy (VAB). Only patients managed using an excisional biopsy or with at least one year of documented radiological follow-up were included. For each, the Breast Imaging Reporting and Data System (BI-RADS) category, number of samples, needle thickness, and lesion size were correlated with malignancy upgrade rates in different histologic subtypes. Pearson’s chi-squared test, the Fisher–Freeman–Halton test, and Fisher’s exact test were used for the statistical analyses.RESULTSThe overall upgrade rate was 20.6%, with the highest rates in the subtypes of intraductal papilloma (IP) with atypia (44.7%; 55/123), followed by atypical ductal hyperplasia (ADH) (38.4%; 144/375), lobular neoplasia (LN) (12.7%; 7/55), papilloma without atypia (9.4%; 58/611), flat epithelial atypia (FEA) (8.7%; 10/114), and radial scars (RSs) (4.6%; 3/65). There was a significant relationship between the upgrade rate and BI-RADS category, number of samples, and lesion size Lesion size was the most predictive factor for an upgrade in all subtypes.CONCLUSIONADH and atypical IP showed considerable upgrade rates to malignancy, requiring surgical excision. The LN, IP without atypia, pure FEA, and RS subtypes showed lower malignancy rates when the BI-RADS category was lower and in smaller lesions that had been adequately sampled using VAB. After being discussed in a multidisciplinary meeting, these cases could be managed with follow-up instead of excision

The effects of alternating magnetic field on the biomechanic parameters of streptozotocin-induced diabetic rat diaphragma muscles.

TEZ5604Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2005.Kaynakça (s. 100-103) var.xiv, 105 s. ; 29 cm.Diabetes mellitus is characterise with the disorders in carbohydrate protein and lipid metabolisms owing to the insufficient insulin secretion. Diabet is a disease with a high prevelance in society. In recent years, it has been known that the effects of magnetic field applications with modulation on various diseases have been examined. It is also known that diabet changes the contractile and electrical features of the skeletal muscle. On the other hand, the effects of the magnetic field on the diabetic diaphragm muscle aren't exactly known. For this reason, the effects which the magnetic field with chronic modulation (MMA) would provide on the morphological structures, biochemical parameters and on biomechanic and bioelectrical parameters of diaphragm muscle strips of the experimental diabetic rats which are induced through streptozotocin were examined....Diabetes mellitus, rölatif insülin sekresyonu yetersizligi nedeniyle karbonhidrat, protein ve lipit metabolizmasindaki bozukluklariyla karakterizedir. Diyabet prevelansi toplumda yüksek olan bir hastaliktir. Son yillarda modülasyonlu manyetik alan uygulamalarinin özellikle tedavi amaçli çesitli hastaliklar üzerinde etkilerinin arastirildigi bilinmektedir. Diyabetin iskelet kasinin kontraktil ve elektriksel özelliklerini degistirdigi de bilinmektedir. Diyafram kasi ise solunum fonksiyonu için eksen konumunda olan önemli bir iskelet kasidir. Manyetik alanin diyabetik diyafram kasi üzerine etkileri ise bilinmemektedir. Bundan dolayi, bu çalismada STZ ile olusturulan deneysel diyabetli siçanlarin diyafram kasi striplerinin biyomekanik ve biyoelektriksel parametrelerinde, biyokimyasal degerler ve morfolojik yapilarinda kronik modülasyonlu manyetik alanin (MMA) olusturacagi etkiler incelendi....Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje No: SBE2002D16

AC manyetik alanın sıçanlarda biyomekanik ve hematolojik parametrelere etkisinin araştırılması

TEZ1840Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 1995.Kaynakça (s. 41-45) var.45 s. : rnk. res. ; 30 cm.

The Effects of Magnetic Field on the Electrophysiological Parameters of Soleus Muscle in Streptozotocin-Induced Diabetic Rats

Giriş: Streptozotosin (STZ) ile deneysel diyabet oluşturulan sıçanlar elektromanyetik alana maruz bırakıldıktan sonra soleus kas preparatlarından dinlenim zar potansiyeli ve kas aksiyon potansiyelinin ölçülerek incelenmesi. Materyal ve Metod: Bu çalışmada 40 adet Wistar türü erkek sıçan kullanıldı. Sıçanlar dört gruba bölündü; Grup I (Kontrol), Grup II (Manyetik alan kontrolü), Grup III (Diyabetik), Grup IV (diyabet uygulanmış manyetik alan grubu). Diyabet tek doz halinde (45 mg/kg ) ketamin ve ksilazin kombinasyon anestezisi altında citrat tamponu içerisine karıştırılmış STZ olarak jügüler venden verildi. Konvensiyonel mikroeletrod tekniği ile dinlenim zar potansiyeli, aksiyon potansiyeli, depolarizasyon ve repolarizasyon süresi, kas aksiyon potansiyeli integrali kayıtlandı. Tartışma: Manyetik alan hücre membranında dinlenim zar potansiyelinin uyarılabilirliğini arttırdı. Bu da hücre membranlarının daha fazla depolarize edilmiş olduğunu göstermektedir. Bu depolarizasyon durumunun artması K ve/veya Cl iyon kanallarının iletkenliğindeki değişimlerden kaynaklanabileceği varsayılmaktadır. Sonuçlar: Dinlenim zar potansiyeli, Grup I, III ve IV arasında anlamlı bir azalma bulunmuştur (p<0.05). Kas Aksiyon Potansiyelleri diğer gruplarla karşılaştırıldığında sonuçlar anlamlı bulundu. Depolarizasyon süresini karşılaştırdığımızda Grup I, III ve IV ararsında anlamlı bir artış gözlendi. Bunun yanında yarı repolarizasyon süresi, kas aksiyon potansiyeli integrali, depolarizasyon ve repolarizasyon sürelerinin anlamlı bir şekilde düştüğü görüldü.Purpose: To investigate the effects of magnetic field (MF) on the resting membrane potential and action potential parameters of the Soleus muscle preparations in streptozotocin (STZ) induced diabetic rats. Material and Methods: Forty male wistar rats were used in this study. The rats were divided into four groups; Group I (control), Group II (control with magnetic field), group III (diabetic), group IV (diabetic with magnetic field). The diabetes was induced by a single intravenous injection of STZ (45 mg/kg) in citrate buffer to the jugular vein under the ketamine and xylazine anesthetic combination. Resting membrane potential (RMP), muscle action potential (MAP), depolarization and half-repolarization time, MAP integral, depolarization and repolarization rates were recorded by means of the conventional microelectrode technique. Results: When group III and IV compared to group I, a significant decrease was found in the RMP (<0.05). When control group compared to the other groups, MAP values found to be significant. When the depolarization time was compared there was a significant increase difference between group I and group III and group IV. Furthermore, halfrepolarization time, MAP integral, depolarization and repolarization rates showed significant decrease results as occurred in MAP. Conclusion: MF increased the excitability of the cell membrane in RMP, which revealed that cell membrane had been more depolarized. It was assumed that this increase in depolarization may have been due to the changes in the conductivity of K+ and/or Cl- ion channels

Nitrik Oksit Sentaz NOS İnhibitörlerinin Sıçanlarda Çok Düşük Frekanslı Manyetik Alanın İndüklediği Analjezi Üzerine Etkileri

Amaç: Elektromanyetik alanın EMA farklı ağrı türlerini azalttığı bilinmektedir. Bununla birlikte, manyetik alanın analjezik etki mekanizması tam olarak anlaşılamamıştır. Bu çalışmanın amacı, nitrik oksit sentaz NOS inhibitörlerinin sıçanlarda çok düşük frekanslı EMA maruziyeti ile oluşan analjezi üzerine etkilerini araştırmaktır.Gereç ve Yöntem: Bu çalışmada 72 yetişkin erkek Wistar albino sıçan yaklaşık 230 ± 12 g ağırlığında kullanıldı. Sıçanlar, 22 ± 2 °C oda sıcaklığında, 12 saat aydınlık/karanlık siklusun sağlandığı ve ses yalıtımı olan ortamda tutuldu. Elektromanyetik alan 50 Hz , her gün dört defa 30 dakika süre ve 15 dakika aralıklar ile 15 gün boyunca uygulandı. Analjezik etki ölçümü tail-flick ve hot-plate testleri ile gerçekleştirildi. Analjezi testinden önce sıçanlara nitrik oksit donörü SNAP 30 mg/kg ve NOS inhibitörleri L-NAME 40 mg/kg ve 7-NI 25 mg/kg intraperitoneal olarak enjekte edildi. Verilerin istatistiksel analizinde varyans analizi iki yönlü ANOVA kullanılmış ve çoklu karşılaştırma Tukey testleri ile yapıldı. İstatistiksel olarak anlamlılık düzeyi

Delayed habituation in Behcet's disease

WOS: 000254671200006PubMed: 18310833Background: The autonomic nervous system in Behcet's patients may be affected due to various reasons. This entity may be detected with the measurement of the electrodermal activities, heart rate variability and pupillometric methods. Habituation is one of the implicit forms of learning and memory and the loss of habituation can reveal pathological changes in the synaptic regions. Aim: To determine whether there is a functional decrease in the synaptic effectiveness (habituation) of the pathways to sympathetic neurons that had been repeatedly activated in Behcet's. Materials and Methods: Twelve patients with Behcet's disease and 12 healthy controls were included in the study. Sympathetic skin potential (SSP) records were taken at normal room temperature in a quiet place within a Faraday cage. Sixteen square wave single shock impulses (duration: 1200 mu s, strength: 5 mA) were applied on each case. Results: After the 1(st) stimulus, the SSP amplitudes were lower in the patients compared to the controls (P 0.001, t value = 7.69). There was no significant differences among the SSP amplitudes after the 13(th) impulse in the patients (P>0.05). Whereas there was no significant differences among the SSP amplitudes after the 9(th) impulse in the controls (P>0.05). The habituation rate of the SSP after consecutive impulses was slowest in the patients compared to controls (P<0.001, t value = 12.39). Conclusions: There is a delayed habituation in Behcet's disease and that may due to pathologic changes with vasculitis through their peripheral nerves

Prognostic significance of blood group antigen expression of tumor tissue in lung cancer patients

WOS: 000179685900009PubMed: 12487558Aims and background: Many prognostic factors have been evaluated both for SCLC and NSCLC. The prognostic significance of blood group antigen expression of tumor tissues has been studied particularly in NSCLC, yielding divergent results. The aim of the present study was to investigate the prognostic value of the tumoral expression of blood group antigens ABH in lung cancer. Methods: The presence of blood group antigens was assessed immunohistochemically in paraffin-embedded tumor samples from 92 patients diagnosed between 1996 and 1997. Monoclonal antibodies were used to detect blood group antigens. Results: The median survival was longer in NSCLC patients whose tumors were positive for blood group antigen A (P = 0.009). Since the expression of blood group antigen A in tumor cells was limited to patients with type A or AB blood, survival analysis of these patients showed survival to be longer in non-small cell lung cancer patients with blood group antigen A-positive tumors (P = 0.0019). Conclusions: Expression of blood group antigen A in tumor cells is an important, favorable prognostic factor in patients with non-small cell lung cancer, which could be useful to stratify patients with blood group A or AB according to possible outcome, and to guide therapeutic decision-making. The expression of blood group antigens ABH should be evaluated in larger series of lung cancer patients (including small and non-small cell lung cancer) with all blood types