Emotional Strategies as Catalysts for Cooperation in Signed Networks

The evolution of unconditional cooperation is one of the fundamental problems in science. A new solution is proposed to solve this puzzle. We treat this issue with an evolutionary model in which agents play the Prisoner's Dilemma on signed networks. The topology is allowed to co-evolve with relational signs as well as with agent strategies. We introduce a strategy that is conditional on the emotional content embedded in network signs. We show that this strategy acts as a catalyst and creates favorable conditions for the spread of unconditional cooperation. In line with the literature, we found evidence that the evolution of cooperation most likely occurs in networks with relatively high chances of rewiring and with low likelihood of strategy adoption. While a low likelihood of rewiring enhances cooperation, a very high likelihood seems to limit its diffusion. Furthermore, unlike in non-signed networks, cooperation becomes more prevalent in denser topologies.Comment: 24 pages, Accepted for publication in Advances in Complex System

Freezing and Slow Evolution in a Constrained Opinion Dynamics Model

We study opinion formation in a population that consists of leftists, centrists, and rightist. In an interaction between neighboring agents, a centrist and a leftist can become both centrists or leftists (and similarly for a centrist and a rightist). In contrast, leftists and rightists do not affect each other. The initial density of centrists rho_0 controls the evolution. With probability rho_0 the system reaches a centrist consensus, while with probability 1-rho_0 a frozen population of leftists and rightists results. In one dimension, we determine this frozen state and the opinion dynamics by mapping the system onto a spin-1 Ising model with zero-temperature Glauber kinetics. In the frozen state, the length distribution of single-opinion domains has an algebraic small-size tail x^{-2(1-psi)} and the average domain size grows as L^{2*psi}, where L is the system length. The approach to this frozen state is governed by a t^{-psi} long-time tail with psi-->2*rho_0/pi as rho_0-->0.Comment: 4 pages, 6 figures, 2-column revtex4 format, for submission to J. Phys. A. Revision contains lots of stylistic changes and 1 new result; the main conclusions are the sam

Neurophysiology

Contains reports on two research projects.Bell Telephone Laboratories, IncorporatedNational Institutes of HealthTeagle Foundation, IncorporatedUnited States Air Force, Aeronautical Systems Division (Contract AF33(616)-7783

Invariants from classical field theory

We introduce a method that generates invariant functions from perturbative classical field theories depending on external parameters. Applying our methods to several field theories such as abelian BF, Chern-Simons and 2-dimensional Yang-Mills theory, we obtain, respectively, the linking number for embedded submanifolds in compact varieties, the Gauss' and the second Milnor's invariant for links in S^3, and invariants under area-preserving diffeomorphisms for configurations of immersed planar curves.Comment: 20 pages, 1 figure, to appear in J. Math. Phy

Consistent reactive participation of group members and reduction of intergroup conflict

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68015/2/10.1177_002200275900300103.pd

Hereditary sensory and autonomic neuropathies: types II, III, and IV

The hereditary sensory and autonomic neuropathies (HSAN) encompass a number of inherited disorders that are associated with sensory dysfunction (depressed reflexes, altered pain and temperature perception) and varying degrees of autonomic dysfunction (gastroesophageal reflux, postural hypotention, excessive sweating). Subsequent to the numerical classification of four distinct forms of HSAN that was proposed by Dyck and Ohta, additional entities continue to be described, so that identification and classification are ongoing. As a group, the HSAN are rare diseases that affect both sexes. HSAN III is almost exclusive to individuals of Eastern European Jewish extraction, with incidence of 1 per 3600 live births. Several hundred cases with HSAN IV have been reported. The worldwide prevalence of HSAN type II is very low. This review focuses on the description of three of the disorders, HSAN II through IV, that are characterized by autosomal recessive inheritance and onset at birth. These three forms of HSAN have been the most intensively studied, especially familial dysautonomia (Riley-Day syndrome or HSAN III), which is often used as a prototype for comparison to the other HSAN. Each HSAN disorder is likely caused by different genetic errors that affect specific aspects of small fiber neurodevelopment, which result in variable phenotypic expression. As genetic tests are routinely used for diagnostic confirmation of HSAN III only, other means of differentiating between the disorders is necessary. Diagnosis is based on the clinical features, the degree of both sensory and autonomic dysfunction, and biochemical evaluations, with pathologic examinations serving to further confirm differences. Treatments for all these disorders are supportive

An analog retina model for detecting dim moving objects against a bright moving background

We are interested in applications that require the ability to track a dim target against a bright, moving background. Since the target signal will be less than or comparable to the variations in the background signal intensity, sophisticated techniques must be employed to detect the target. We present an analog retina model that adapts to the motion of the background in order to enhance targets that have a velocity difference with respect to the background. Computer simulation results and our preliminary concept of an analog 'Z' focal plane implementation are also presented

Renormalization Ambiguities in Chern-Simons Theory

We introduce a new family of gauge invariant regularizations of Chern-Simons theories which generate one-loop renormalizations of the coupling constant of the form $k\to k+2 s c_v$ where $s$ can take any arbitrary integer value. In the particular case $s=0$ we get an explicit example of a gauge invariant regularization which does not generate radiative corrections to the bare coupling constant. This ambiguity in the radiative corrections to $k$ is reminiscent of the Coste-L\"uscher results for the parity anomaly in (2+1) fermionic effective actions.Comment: 10 pages, harvmac, no changes, 1 Postscript figure (now included

Poly‐aneuploid cancer cells promote evolvability, generating lethal cancer

Cancer cells utilize the forces of natural selection to evolve evolvability allowing a constant supply of heritable variation that permits a cancer species to evolutionary track changing hazards and opportunities. Over time, the dynamic tumor ecosystem is exposed to extreme, catastrophic changes in the conditions of the tumor—natural (e.g., loss of blood supply) or imposed (therapeutic). While the nature of these catastrophes may be varied or unique, their common property may be to doom the current cancer phenotype unless it evolves rapidly. Poly‐aneuploid cancer cells (PACCs) may serve as efficient sources of heritable variation that allows cancer cells to evolve rapidly, speciate, evolutionarily track their environment, and most critically for patient outcome and survival, permit evolutionary rescue, therapy resistance, and metastasis. As a conditional evolutionary strategy, they permit the cancer cells to accelerate evolution under stress and slow down the generation of heritable variation when conditions are more favorable or when the cancer cells are closer to an evolutionary optimum. We hypothesize that they play a critical and outsized role in lethality by their increased capacity for invasion and motility, for enduring novel and stressful environments, and for generating heritable variation that can be dispensed to their 2N+ aneuploid progeny that make up the bulk of cancer cells within a tumor, providing population rescue in response to therapeutic stress. Targeting PACCs is essential to cancer therapy and patient cure—without the eradication of the resilient PACCs, cancer will recur in treated patients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156440/2/eva12929_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156440/1/eva12929.pd