Isolated Gallbladder Rupture Due to Blunt Abdominal Trauma

Traumatic injury to the extrahepatic biliary system is rare and usually diagnosed at laparotomy when it is associated with other visceral injuries. Isolated gallbladder rupture due to blunt abdominal trauma is even rarer. The clinical presentation of gallbladder injury is variable, resulting in a delay in diagnosis and treatment. Awareness to the possibilty of trauma to the extrahepatic biliary system enables early surgical intervention and eliminates the high morbidity associated with delated diagnosis

Optimization of Adaptation - A Multi-objective Approach for Optimizing Changes to Design Parameters

Dynamic optimization problems require constant tracking of the optimum. A solution for such a problem has to be adjustable in order to remain optimal as the optimum changes. The manner of changing design parameters to predefined values is dealt with in the field of control. Common control approaches do not consider the optimality of the design, in terms of the objective function, while adjusting to the new solution. This study highlights the issue of the optimality of adaptation, and defines a new optimization problem – ”Optimization of Adaptation”. It is a multiobjective problem that considers the cost of the adaptation and the optimality while the adaptation takes place. An evolutionary algorithm is proposed in order to solve this problem, and it is demonstrated, first, with an academic example, and then with a real life application of a robotic arm control

Effects of temperature and glycerol and methanol-feeding profiles on the production of recombinant galactose oxidase in Pichia pastoris

Optimization of protein production from methanol-induced Pichia pastoris cultures is necessary to ensure high productivity rates and high yields of recombinant proteins. We investigated the effects of temperature and different linear or exponential methanol-feeding rates on the production of recombinant Fusarium graminearum galactose oxidase (EC 1.1.3.9) in a P. pastoris Mut+ strain, under regulation of the AOX1 promoter. We found that low exponential methanol feeding led to 1.5-fold higher volumetric productivity compared to high exponential feeding rates. The duration of glycerol feeding did not affect the subsequent product yield, but longer glycerol feeding led to higher initial biomass concentration, which would reduce the oxygen demand and generate less heat during induction. A linear and a low exponential feeding profile led to productivities in the same range, but the latter was characterized by intense fluctuations in the titers of galactose oxidase and total protein. An exponential feeding profile that has been adapted to the apparent biomass concentration results in more stable cultures, but the concentration of recombinant protein is in the same range as when constant methanol feeding is employed. (c) 2014 The Authors Biotechnology Progress published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers Biotechnol. Prog., 30:728-735, 201

The Epsilon Calculus and Herbrand Complexity

Hilbert's epsilon-calculus is based on an extension of the language of predicate logic by a term-forming operator $\epsilon_{x}$. Two fundamental results about the epsilon-calculus, the first and second epsilon theorem, play a role similar to that which the cut-elimination theorem plays in sequent calculus. In particular, Herbrand's Theorem is a consequence of the epsilon theorems. The paper investigates the epsilon theorems and the complexity of the elimination procedure underlying their proof, as well as the length of Herbrand disjunctions of existential theorems obtained by this elimination procedure.Comment: 23 p

The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in <i>Streptomyces</i>

The filamentous bacterium Streptomyces lividans depends on the radical copper oxidase GlxA for the formation of reproductive aerial structures and, in liquid environments, for the formation of pellets. Incorporation of copper into the active site is essential for the formation of a cross-linked tyrosyl-cysteine cofactor, which is needed for enzymatic activity. In this study, we show a crucial link between GlxA maturation and a group of copper-related proteins including the chaperone Sco and a novel DyP-type peroxidase hereinafter called DtpA. Under copper-limiting conditions, the sco and dtpA deletion mutants are blocked in aerial growth and pellet formation, similarly to a glxA mutant. Western blot analysis showed that GlxA maturation is perturbed in the sco and dtpA mutants, but both maturation and morphology can by rescued by increasing the bioavailability of copper. DtpA acts as a peroxidase in the presence of GlxA and is a substrate for the twin-arginine translocation (Tat) translocation pathway. In agreement, the maturation status of GlxA is also perturbed in tat mutants, which can be compensated for by the addition of copper, thereby partially restoring their morphological defects. Our data support a model wherein a copper-trafficking pathway and Tat-dependent secretion of DtpA link to the GlxA-dependent morphogenesis pathway. </jats:p

Introduction to Milestones in Interactive Theorem Proving

On March 8, 2018, Tobias Nipkow celebrated his sixtieth birthday. In anticipation of the occasion, in January 2016, two of his former students, Gerwin Klein and Jasmin Blanchette, and one of his former postdocs, Andrei Popescu, approached the editorial board of the Journal of Automated Reasoning with a proposal to publish a surprise Festschrift issue in his honor. The e-mail was sent to twenty-six members of the board, leaving out one, for reasons that will become clear in a moment. It is a sign of the love and respect that Tobias commands from his colleagues that within two days every recipient of the e-mail had responded favorably and enthusiastically to the proposal

On the computational content of Zorn's lemma

We give a computational interpretation to an abstract instance of Zorn's lemma formulated as a wellfoundedness principle in the language of arithmetic in all finite types. This is achieved through G\"odel's functional interpretation, and requires the introduction of a novel form of recursion over non-wellfounded partial orders whose existence in the model of total continuous functionals is proven using domain theoretic techniques. We show that a realizer for the functional interpretation of open induction over the lexicographic ordering on sequences follows as a simple application of our main results

An Evolutionary Approach to Active Robust Multiobjective Optimisation

An Active Robust Optimisation Problem (AROP) aims at finding robust adaptable solutions, i.e. solutions that actively gain robustness to environmental changes through adaptation. Existing AROP studies have considered only a single performance objective. This study extends the Active Robust Optimisation methodology to deal with problems with more than one objective. Once multiple objectives are considered, the optimal performance for every uncertain parameter setting is a set of configurations, offering different trade-offs between the objectives. To evaluate and compare solutions to this type of problems, we suggest a robustness indicator that uses a scalarising function combining the main aims of multi-objective optimisation: proximity, diversity and pertinence. The Active Robust Multi-objective Optimisation Problem is formulated in this study, and an evolutionary algorithm that uses the hypervolume measure as a scalarasing function is suggested in order to solve it. Proof-of-concept results are demonstrated using a simplified gearbox optimisation problem for an uncertain load demand

A Burgessian critique of nominalistic tendencies in contemporary mathematics and its historiography

We analyze the developments in mathematical rigor from the viewpoint of a Burgessian critique of nominalistic reconstructions. We apply such a critique to the reconstruction of infinitesimal analysis accomplished through the efforts of Cantor, Dedekind, and Weierstrass; to the reconstruction of Cauchy's foundational work associated with the work of Boyer and Grabiner; and to Bishop's constructivist reconstruction of classical analysis. We examine the effects of a nominalist disposition on historiography, teaching, and research.Comment: 57 pages; 3 figures. Corrected misprint