On the application of massive mimo systems to machine type communications

This paper evaluates the feasibility of applying massive multiple-input multiple-output (MIMO) to tackle the uplink mixed-service communication problem. Under the assumption of an available physical narrowband shared channel, devised to exclusively consume data traffic from machine type communications (MTC) devices, the capacity (i.e., number of connected devices) of MTC networks and, in turn, that of the whole system, can be increased by clustering such devices and letting each cluster share the same time-frequency physical resource blocks. Following this research line, we study the possibility of employing sub-optimal linear detectors to the problem and present a simple and practical channel estimator that works without the previous knowledge of the large-scale channel coefficients. Our simulation results suggest that the proposed channel estimator performs asymptotically, as well as the MMSE estimator, with respect to the number of antennas and the uplink transmission power. Furthermore, the results also indicate that, as the number of antennas is made progressively larger, the performance of the sub-optimal linear detection methods approaches the perfect interference-cancellation bound. The findings presented in this paper shed light on and motivate for new and exciting research lines toward a better understanding of the use of massive MIMO in MTC networks

Tuberculous meningitis in HIV-infected patients in Brazil: clinical and laboratory characteristics and factors associated with mortality

Tuberculous meningitis (TBM) is a growing problem in HIV-infected patients in developing countries, where there is scarce data about this co-infection. Our objectives were to analyze the main features and outcomes of HIV-infected patients with TBM. Methods This was a retrospective study of HIV-infected Brazilian patients admitted consecutively for TBM. All patients had Mycobacterium tuberculosis isolated from the cerebrospinal fluid (CSF). Presenting clinical and laboratory features were studied. Multivariate analysis was used to identify variables associated with death during hospitalization and at 9 months after diagnosis. Survival was estimated using the Kaplan–Meier method. Results We included 108 cases (median age 36 years, 72% male). Only 15% had fever, headache, and meningeal signs simultaneously. Forty-eight percent had extrameningeal tuberculosis. The median CD4+ cell count was 65 cells/μl. Among 90 cases, 7% had primary resistance to isoniazid and 9% presented multidrug-resistant strains. The overall mortality during hospitalization was 29% and at 9 months was 41%. Tachycardia and prior highly active antiretroviral therapy (HAART) were associated with 9-month mortality. The 9-month survival rate was 22% (95% confidence interval 12–43%). Conclusions Clinical and laboratory manifestations were unspecific. Disseminated tuberculosis and severe immunosuppression were common. Mortality was high and the 9-month survival rate was low. Tachycardia and prior HAART were associated with death within 9 months of diagnosis147e586e59

\u3cem\u3eStylosanthes\u3c/em\u3e cv. Campo Grande in Diets of Beef Cattle: Intake and Digestibility of Nutrients and Ruminal Fermentation

Recent studies have shown that it is possible to obtain well-fermented silages from tropical legumes (Heinritz et al., 2012). Souza et al. (2014) concluded that Stylosanthes cv. Campo Grande silage (StS); (Stylosantes capitata + S. macrocephala), when included in the proportion of 50% dietary dry matter (DM), could replace corn silage in diets of feedlot beef cattle without altering intake and performance. However, there is a lack of information about increasing proportion of StS that should be included in diets for beef cattle. Thus, the objective of this study was to evaluate the intake and digestibility of nutrients, and ruminal fermentation of beef cattle fed diets with Stylosanthes and concentrate in different levels

Attenuated PGC-1 alpha Isoforms following Endurance Exercise with Blood Flow Restriction

Introduction: Exercise performed with blood flow restriction simultaneously enhances the acute responses to both myogenic and mitochondrial pathways with roles in training adaptation. We investigated isoform-specific gene expression of the peroxisome proliferator-activated receptor gamma (PPARG) coactivator 1 and selected target genes and proteins regulating skeletal muscle training adaptation. Methods: 9 healthy, untrained males participated in a randomized, counter-balanced, cross-over design in which each subject completed a bout of low-intensity endurance exercise performed with blood flow restriction (15 min cycling at 40% of VO2peak, BFR-EE), endurance exercise (30 min cycling at 70% of VO2peak, EE) or resistance exercise (4 x 10 repetitions of leg press at 70% of 1-repetition maximum, RE) separated by at least one week recovery. A single resting muscle biopsy (vastus lateralis) was obtained two weeks before the first exercise trial (rest) and 3 h after each boat. Results: Total PGC-1α mRNA abundance, along with all four isoforms, increased above rest with EE only (P<0.05) being higher than BFR-EE (P<0.05). PGC-1α1, 2 and 4 were higher after EE compared to RE (P<0.05). EE also increased VEGF, Hif-1α and MuRF-1 mRNA abundance above rest (P<0.05) while COXIV mRNA expression increased with EE compared to BFR-EE (P<0.05). Conclusion: The attenuated expression of all four PGC- 1α isoforms when endurance exercise is performed with blood flow restriction suggests this type of exercise provides an insufficient stimulus to activate the signaling pathways governing mitochondrial and angiogenesis responses observed with moderate- to high intensity endurance exercise