638 research outputs found
Structural studies of the 26S proteasome and its interaction with Ubp6 by cryo-electron microscopy
Code of Best Practices in Fair Use for OnLine Video
Until the release of these best practices, anyone uploading a video ran the risk of becoming inadvertently entangled in an industry skirmish, as media companies struggle to keep their programs from circulating on the internet. This document is a code of best practices created by a collaborative team of media scholars and lawyers, to help creators, online providers, copyright holders, and others interested in the making of online video, interpret the copyright doctrine of fair use in online video. The code identifies, among other things, six kinds of unlicensed uses of copyrighted material that may be considered fair, under certain limitations
Code of Best Practices in Fair Use for OnLine Video
Until the release of these best practices, anyone uploading a video ran the risk of becoming inadvertently entangled in an industry skirmish, as media companies struggle to keep their programs from circulating on the internet. This document is a code of best practices created by a collaborative team of media scholars and lawyers, to help creators, online providers, copyright holders, and others interested in the making of online video, interpret the copyright doctrine of fair use in online video. The code identifies, among other things, six kinds of unlicensed uses of copyrighted material that may be considered fair, under certain limitations
An ideal solution? Optimising pretreatment methods for artificially mummified ancient Egyptian tissues
RATIONALE
Although the analysis of skeletal remains dominates the study of ancient dietary stable isotopes, mummified bodies also allow shortâterm diet to be studied through the analysis of soft tissues. The application of resins, waxes and oils during mummification can affect the results obtained. This study assesses a range of methods for removing such substances from mummified tissue.
METHODS
An experimental mummification model following ancient Egyptian methods was created using a modern pig leg. Subâsamples of skin, muscle and bone were removed and coated with a range of substances used in Egyptian mummification. Four methods were used to clean these samples before the measurement of the carbon and nitrogen stable isotope ratios of their gelatinised collagen content using a ThermoFinnigan Flash Elemental analyser coupled to a DeltaPlus XL isotope ratio mass spectrometer via a ConFlo III interface.
RESULTS
The results showed that embalming materials can significantly affect dietary stable isotope ratios, and that these substances are most effectively removed using a mixture of polar and nonâpolar solvents. Results indicate that bone samples demineralised with HCl and skin samples produce more accurate results than bone samples demineralised with EDTA or muscle samples.
CONCLUSIONS
The choice of tissue and the preparation methods used can have a significant effect on the accuracy of stable isotope data obtained from mummified tissue, particularly when embalming materials are also present. A mixture of solvents appears to be a more effective cleaning agent than a single solvent. Demineralisation with HCl is preferable for wellâpreserved bone as used in this study, but whether this is the case for more fragile, less wellâpreserved bone requires further study. Skin samples produce more consistent data than muscle, but visually distinguishing between these tissues is not simple on ancient mummies
Mixing-induced anisotropic correlations in molecular crystalline systems
We investigate the structure of mixed thin films composed of pentacene (PEN)
and diindenoperylene (DIP) using X-ray reflectivity and grazing incidence X-ray
diffraction. For equimolar mixtures we observe vanishing in-plane order
coexisting with an excellent out-of-plane order, a yet unreported disordering
behavior in binary mixtures of organic semiconductors, which are crystalline in
their pure form. One approach to rationalize our findings is to introduce an
anisotropic interaction parameter in the framework of a mean field model. By
comparing the structural properties with those of other mixed systems, we
discuss the effects of sterical compatibility and chemical composition on the
mixing behavior, which adds to the general understanding of interactions in
molecular mixtures.Comment: 5 pages, 5 figures, accepted by Phys. Rev. Let
Analytical in vitro approach for studying cyto- and genotoxic effects of particulate airborne material
In the field of inhalation toxicology, progress in the development of in vitro methods and efficient exposure strategies now offers the implementation of cellular-based systems. These can be used to analyze the hazardous potency of airborne substances like gases, particles, and complex mixtures (combustion products). In addition, the regulatory authorities require the integration of such approaches to reduce or replace animal experiments. Although the animal experiment currently still has to provide the last proof of the toxicological potency and classification of a certain compound, in vitro testing is gaining more and more importance in toxicological considerations. This paper gives a brief characterization of the CULTEXÂź Radial Flow System exposure device, which allows the exposure of cultivated cells as well as bacteria under reproducible and stable conditions for studying cellular and genotoxic effects after the exposure at the airâliquid or airâagar interface, respectively. A commercial bronchial epithelial cell line (16HBE14o-) as well as Salmonella typhimurium tester strains were exposed to smoke of different research and commercial available cigarettes. A dose-dependent reduction of cell viability was found in the case of 16HBE14o- cells; S. typhimurium responded with a dose-dependent induction of revertants. The promising results recommend the integration of cellular studies in the field of inhalation toxicology and their regulatory acceptance by advancing appropriate validation studies
Electron capture on iron group nuclei
We present Gamow-Teller strength distributions from shell model Monte Carlo
studies of fp-shell nuclei that may play an important role in the pre-collapse
evolution of supernovae. We then use these strength distributions to calculate
the electron-capture cross sections and rates in the zero-momentum transfer
limit. We also discuss the thermal behavior of the cross sections. We find
large differences in these cross sections and rates when compared to the naive
single-particle estimates. These differences need to be taken into account for
improved modeling of the early stages of type II supernova evolution
Gamow-Teller strength distributions in fp-shell nuclei
We use the shell model Monte Carlo method to calculate complete 0f1p-shell
response functions for Gamow-Teller (GT) operators and obtain the corresponding
strength distributions using a Maximum Entropy technique. The approach is
validated against direct diagonalization for 48Ti. Calculated GT strength
distributions agree well with data from (n,p) and (p,n) reactions for nuclei
with A=48-64. We also calculate the temperature evolution of the GT+
distributions for representative nuclei and find that the GT+ distributions
broaden and the centroids shift to lower energies with increasing temperature
Localization of tenascin in human skin wounds
A total of 56 surgically treated human skin wounds with a wound age between 8h and 7 months were investigated. Tenascin was visualized by immunohistochemistry and appeared first in the wound area pericellularly around fibroblastic cells approximately 2 days after wounding. A network-like interstitial positive staining pattern was first detectable in 3-day-old skin wounds. In all wounds with an age of 5 days or more, intensive reactivity for tenascin could be observed in the lesional area (dermal-epidermal junction, wound edge, areas of bleeding). In wounds with an age of more than approximately 1.5 months no positive staining occurred in the scar tissue. In conclusion, for forensic purposes, positive staining for tenascin restricted to the pericellular area of fibroblastic cells indicates a wound age of at least 2 days. Network-like structures appear after approximately 3 days or more. Since tenascin seems to be regularly detectable in skin wounds older than 5 days, the lack of a positive reaction in a sufficient number of specimens indicates a wound age of less than 5 days. The lack of a positive reaction in the granulation tissue of wounds with advanced wound age indicates a survival time of more than about 1.5 months, but a positive staining in older wounds cannot be excluded
Electron fraction constraints based on Nuclear Statistical Equilibrium with beta equilibrium
The electron-to-nucleon ratio or electron fraction is a key parameter in many
astrophysical studies. Its value is determined by weak-interaction rates that
are based on theoretical calculations subject to several nuclear physics
uncertainties. Consequently, it is important to have a model independent way of
constraining the electron fraction value in different astrophysical
environments. Here we show that nuclear statistical equilibrium combined with
beta equilibrium can provide such a constraint. We test the validity of this
approximation in presupernova models and give lower limits for the electron
fraction in type Ia supernova and accretion-induced collapse.Comment: 10 pages, 9 figures, Astronomy and Astrophysic
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