Particle production and equilibrium properties within a new hadron transport approach for heavy-ion collisions

The microscopic description of heavy-ion reactions at low beam energies is achieved within hadronic transport approaches. In this article a new approach SMASH (Simulating Many Accelerated Strongly-interacting Hadrons) is introduced and applied to study the production of non-strange particles in heavy-ion reactions at $E_{\rm kin}=0.4-2A$ GeV. First, the model is described including details about the collision criterion, the initial conditions and the resonance formation and decays. To validate the approach, equilibrium properties such as detailed balance are presented and the results are compared to experimental data for elementary cross sections. Finally results for pion and proton production in C+C and Au+Au collisions is confronted with HADES and FOPI data. Predictions for particle production in $\pi+A$ collisions are made.Comment: 30 pages, 30 figures, replaced with published version; only minor change

Gauge Independence of IR singularities in Non-Commutative QFT - and Interpolating Gauges

IR divergences of a non-commutative U(1) Maxwell theory are discussed at the one-loop level using an interpolating gauge to show that quadratic IR divergences are independent not only from a covariant gauge fixing but also independent from an axial gauge fixing.Comment: 11 pages, 2 figures, v1 minor correction

A Generalization of Slavnov-Extended Non-Commutative Gauge Theories

We consider a non-commutative U(1) gauge theory in 4 dimensions with a modified Slavnov term which looks similar to the 3-dimensional BF model. In choosing a space-like axial gauge fixing we find a new vector supersymmetry which is used to show that the model is free of UV/IR mixing problems, just as in the previously discussed model in arXiv:hep-th/0604154. Finally, we present generalizations of our proposed model to higher dimensions.Comment: 25 pages, no figures; v2 minor correction

A New Approach to Non-Commutative U(N) Gauge Fields

Based on the recently introduced model of arXiv:0912.2634 for non-commutative U(1) gauge fields, a generalized version of that action for U(N) gauge fields is put forward. In this approach to non-commutative gauge field theories, UV/IR mixing effects are circumvented by introducing additional 'soft breaking' terms in the action which implement an IR damping mechanism. The techniques used are similar to those of the well-known Gribov-Zwanziger approach to QCD.Comment: 11 pages; v2 minor correction

On Non-Commutative U*(1) Gauge Models and Renormalizability

Based on our recent findings regarding (non-)renormalizability of non-commutative U*(1) gauge theories [arxiv:0908.0467, arxiv:0908.1743] we present the construction of a new type of model. By introducing a soft breaking term in such a way that only the bilinear part of the action is modified, no interaction between the gauge sector and auxiliary fields occurs. Demanding in addition that the latter form BRST doublet structures, this leads to a minimally altered non-commutative U*(1) gauge model featuring an IR damping behavior. Moreover, the new breaking term is shown to provide the necessary structure in order to absorb the inevitable quadratic IR divergences appearing at one-loop level in theories of this kind. In the present paper we compute Feynman rules, symmetries and results for the vacuum polarization together with the one-loop renormalization of the gauge boson propagator and the three-point functions.Comment: 20 pages, 4 figures; v2-v4: clarified several points, and minor correction

A Vector Supersymmetry in Noncommutative U(1) Gauge Theory with the Slavnov Term

We consider noncommutative U(1) gauge theory with the additional term, involving a scalar field lambda, introduced by Slavnov in order to cure the infrared problem. we show that this theory, with an appropriate space-like axial gauge-fixing, wxhibits a linear vector supersymmetry similar to the one present in the 2-dimensional BF model. This vector supersymmetry implies that all loop corrections are independent of the $\lambda AA$-vertex and thereby explains why Slavnov found a finite model for the same gauge-fixing.Comment: 18 pages, 3 figures; v2 Acknowledgments adde

Exome sequencing in dementia with Lewy bodies.

Dementia with Lewy bodies (DLB) is the second most common form of degenerative dementia. Siblings of affected individuals are at greater risk of developing DLB, but little is known about the underlying genetic basis of the disease. We set out to determine whether mutations in known highly penetrant neurodegenerative disease genes are found in patients with DLB. Whole-exome sequencing was performed on 91 neuropathologically confirmed cases of DLB, supplemented by independent APOE genotyping. Genetic variants were classified using established criteria, and additional neuropathological examination was performed for putative mutation carriers. Likely pathogenic variants previously described as causing monogenic forms of neurodegenerative disease were found in 4.4% of patients with DLB. The APOE ɛ4 allele increased the risk of disease (P=0.0001), conferred a shorter disease duration (P=0.043) and earlier age of death (P=0.0015). In conclusion, although known pathogenic mutations in neurodegenerative disease genes are uncommon in DLB, known genetic risk factors are present in >60% of cases. APOE ɛ4 not only modifies disease risk, but also modulates the rate of disease progression. The reduced penetrance of reported pathogenic alleles explains the lack of a family history in most patients, and the presence of variants previously described as causing frontotemporal dementia suggests a mechanistic overlap between DLB and other neurodegenerative diseases.This study was funded by the NHS National Institute of Health Research Biomedical Research Unit for Lewy body dementia at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Tissue for this study was provided by Newcastle Brain Tissue Resource, which is funded in part by a grant from the UK Medical Research Council and by Brains for Dementia Research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK. MJK is a Wellcome Trust Clinical Research Training Fellow. PFC is a Wellcome Trust Senior Fellow in Clinical Science and National Institute for Health Research Senior Investigator. He receives funding from the Medical Research Council and the National Institute for Health Research Biomedical Research Centre for Ageing and Age-Related Disease award to the Newcastle upon Tyne Foundation Hospitals National Health Service Trust. The funding sources had no role in study design, data collection/analysis, the writing of the paper or the decision of when or where to publish it. The views expressed here are the views of the authors and not necessarily those of the NHS, NIHR or the Department of Health.This is the final published version. It first appeared at http://www.nature.com/tp/journal/v6/n2/full/tp2015220a.html

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.

Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, it remains poorly understood how these mechanisms further evolved in higher organisms. Here we describe a modification in the autophagy pathway in vertebrates, which promotes its activity in response to oxidative stress. We have identified two oxidation-sensitive cysteine residues in a prototypic autophagy receptor SQSTM1/p62, which allow activation of pro-survival autophagy in stress conditions. The Drosophila p62 homologue, Ref(2)P, lacks these oxidation-sensitive cysteine residues and their introduction into the protein increases protein turnover and stress resistance of flies, whereas perturbation of p62 oxidation in humans may result in age-related pathology. We propose that the redox-sensitivity of p62 may have evolved in vertebrates as a mechanism that allows activation of autophagy in response to oxidative stress to maintain cellular homoeostasis and increase cell survival

Phase transitions, inhomogeneous horizons and second-order hydrodynamics

We use holography to study the spinodal instability of a four-dimensional, strongly-coupled gauge theory with a first-order thermal phase transition. We place the theory on a cylinder in a set of homogeneous, unstable initial states. The dual gravity configurations are black branes afflicted by a Gregory-Laflamme instability. We numerically evolve Einstein’s equations to follow the instability until the system settles down to a stationary, inhomogeneous black brane. The dual gauge theory states have constant temperature but non-constant energy density. We show that the time evolution of the instability and the final states are accurately described by second-order hydrodynamics. In the static limit, the latter reduces to a single, second-order, non-linear differential equation from which the inhomogeneous final states can be derived