49 research outputs found
Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC).
International audienceBACKGROUND AND OBJECTIVES: High-dose chemotherapy with allogeneic stem cell transplantation (SCT) has proven to be a successful treatment for low-grade lymphoma (LGL), but is associated with considerable transplant-related mortality (TRM). In an effort to reduce toxic mortality while maintaining the graft-versus-leukemia effect, allogeneic SCT has been combined with a reduced-intensity conditioning (RIC) regimen. The aim of this study was to determine the outcome of patients with LGL treated with RIC allogeneic SCT. DESIGN AND METHODS: This retrospective multicenter study included 73 patients with relapsed or refractory LGL allografted after a RIC regimen between 1998 and 2005 whose data were recorded in a French registry. RESULTS: Patients received a median of three lines of therapy prior to RIC allogeneic SCT. The most widely used conditioning regimens were fludarabine + busulfan + antithymocyte globulin (n=43) and fludarabine + total body irradiation (n=21). Prior to allografting, patients were in complete response (CR; n=21), partial response (PR; n=33) or had chemoresistant disease (n=19). The median follow-up was 37 months (range, 16 to 77 months). In patients in CR, PR and chemoresistant disease, the 3-year overall survival rates were 66%, 64% and 32%, respectively, while the 3-year event-free survival rates were 66%, 52% and 32%, respectively. The 3-year cumulative incidences of TRM were 32%, 28% and 63%, respectively. The incidence of relapse was 9.6%. INTERPRETATION AND CONCLUSIONS: Although associated with significant TRM, RIC allogeneic SCT in advanced chemosensitive disease leads to long-term survival
Le Midi italien, terre de mission du PCI aprĂšs la Seconde Guerre mondiale
LâĂ©conomie et la sociĂ©tĂ© du Midi italien aprĂšs la Seconde Guerre mondiale diffĂšrent peu de celles qui lâavaient caractĂ©risĂ© aprĂšs lâUnitĂ© et qui avaient dĂ©fini les termes de ce quâon appelle la question mĂ©ridionale. Tous les chiffres qui concourent Ă la mesure de lâindice de dĂ©veloppement humain dĂ©montrent lâarriĂ©ration des rĂ©gions mĂ©ridionales : analphabĂ©tisme largement persistant, monde rural prĂ©pondĂ©rant, Ă©conomie agricole sous-dĂ©veloppĂ©e, une ville-monstre, Naples et sa pĂ©riphĂ©rie, quelqu..
Lâaction de la Fondation Ford en Europe et la promotion des sciences sociales : le rapport de Robert Taylor Cole de 1966
National audienc
Piero Calamandrei et la Constitution de 1948Â : Calamandrei le juriste contre Piero lâintellectuel
Piero Calamandrei was a well-known legal-adviser and an intellectual engagé. He founded and directed a political and cultural monthly magazine, still alive, Il Ponte, which was committed in the Fifties in the rank of the non-communist, non Marxist and neutralist Left wing. He was also a most competent member of the Committee of 75 in charge of writing the Constitution. This paper studies how Calamandrei stood for a presidential system, inspired of the American Constitution, while most of his political friends, from the Socialist and the Communist Parties supported a traditional parliamentary Constitution. If the intellectual was more and more attracted by the Radicals, the constitutional lawyer remained linked to a very classical and orthodox conception of liberalism
La monarchie italienne est-elle encore légitime en 1943-1944 ? La question institutionnelle dans le « Regno del Sud »
Attal FrĂ©dĂ©ric. La monarchie italienne est-elle encore lĂ©gitime en 1943-1944 ? La question institutionnelle dans le « Regno del Sud ». In: Revue dâhistoire moderne et contemporaine, tome 45 N°1, Janvier-mars 1998. Pouvoirs et sociĂ©tĂ©s en Italie XVIe-XXe siĂšcles. pp. 227-253
Arturo Carlo Jemolo : itinĂ©raire dâun historien catholique libĂ©ral au xxe siĂšcle
Peut-on dĂ©finir avec exactitude la position idĂ©ologique et politique dâArturo Carlo Jemolo dans lâItalie du xxe siĂšcle, et notamment celle qui concerne sa vision de lâĂglise et du Saint-SiĂšge ? Catholique, il nâa jamais appartenu Ă un parti politique se rĂ©clamant du christianisme, ni mĂȘme votĂ© pour lui ; libĂ©ral, il appelle Ă voter pour le Front dĂ©mocratique populaire en 1948 â alliance formĂ©e autour des Partis communiste et socialiste italiens â, alors quâaucun idĂ©ologue libĂ©ral ne trouve vĂ©..
La diplomazia culturale statunitense e il Mezzogiorno negli anni Cinquanta
International audienc
Giuseppe Prezzolini, propagandiste conscient du fascisme
Le parcours politique, durant le ventennio, du fondateur de La Voce et, de ce fait, figure importante du monde intellectuel italien aprĂšs-guerre, est dâautant plus intĂ©ressant que lâhomme sâest toujours dĂ©fendu dâavoir Ă©tĂ© fasciste. La lecture de son journal intime rĂ©vĂšle son habituelle prudence, le souci de se tenir au-dessus de la mĂȘlĂ©e et de nombreuses hĂ©sitations. Pas une ligne sur lâassassinat de Matteotti en 1924, sur la mort de Gobetti, Ă lâenterrement duquel il est pourtant lâun des r..