Association of sleep quality with body fat mass and metabolic factors in Iranian adults in 2020

Background: Poor sleep quality is increasingly recognized as a risk factor for poor health outcomes such as obesity, diabetes and cardiovascular diseases. This study aimed to investigate the association between sleep quality, obesity and glycemic and lipid profiles in Iranian adults in 2020.Methods: 353 adults aged 18-60 years from community centers in Tehran municipality took apart in this cross-sectional study by convenience sampling. Information on anthropometric measurements, physical activity and dietary intake were collected. Sleep quality was assessed through Pittsburgh Sleep Quality Index. Body composition was measured through BIA method. Auto analyzer was used to measure fasting blood sugar (FBS)and lipid profile and ELISA method was used to measure Insulin.Results: The mean age was 42.92±11.34 and 39.16±14.18 for women and men, respectively. Each one score increase in total sleep quality, was related to 0.1 cm increase in waist circumference and 0.3 % increase in body fat percent (P <0.05). BMI had a positive correlation with subscales of “sleep disturbances” and “use of sleep medication” (P <0.001). Physical activity had a significant negative correlation with subscales of “subjective sleep quality” and “sleep latency”. FBS and triglyceride had positive correlation with “sleep latency” and “Subjective sleep quality”, respectively (P <0.05).Conclusion: Some determinants of sleep quality are associated with obesity, disorders of glucose and triglyceride metabolism and low level of physical activity.Keywords: Sleep quality; PSQI questionnaire; Body fat mass; Fasting Blood Sugar; Lipid profil

Effects of probiotic supplementation with weight reducing intervention on anthropometric measures, body composition, eating behavior, and related hormone levels in patients with food addiction and weight regain after bariatric surgery: a study protocol for a randomized clinical trial

Abstract Background One of the unfortunate events after bariatric surgery is the weight regain, which occurs in some patients. Food addiction is an eating disorder related to the brain-intestinal axis and can be effective in weight regain after bariatric surgery. In addition, the gut microbiome plays a vital role in eating behaviors, including food addiction. So, this study will aim to evaluate the effects of probiotic supplementation with a weight-reducing diet and cognitive behavioral therapy on anthropometric measures, body composition, eating behavior, and related hormone levels, leptin, oxytocin, and serotonin, in patients with food addiction and weight regain after bariatric surgery. Methods We will carry out a triple-blinded randomized clinical trial for 12 weeks to evaluate the effect of probiotic supplementation with a weight-reducing diet and cognitive behavioral therapy on anthropometric measures, body composition, eating behavior, and related hormone levels including leptin, oxytocin, and serotonin, in patients with food addiction and weight regain after bariatric surgery. Discussion Based on the available evidence, probiotic supplementation by modifying the intestinal microbiome can improve food addiction and subsequent weight loss. Trial Registration Iranian Registry of Clinical Trials IRCT20220406054437N1 Registered on 2022–06-01

Additional file 1 of Effects of probiotic supplementation with weight reducing intervention on anthropometric measures, body composition, eating behavior, and related hormone levels in patients with food addiction and weight regain after bariatric surgery: a study protocol for a randomized clinical trial

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Fish oil and olive oil can modify insulin resistance and plasma desacyl-ghrelin in rats

Background: Evidence exists for reciprocal effects of insulin and desacyl-ghrelin (DAG) concentration, but the association between different fatty acid saturation in high fat diet (HFD) and these hormones remain to be established. To evaluate the impact of different sources of dietary fat and the level of fatty acid saturation on plasma insulin and DAG levels and also the association of DAG with insulin action this study was carried out. Methods: Male weaning Wistar rats were randomly divided into four groups of HFDs, high fat butter (HF-B), high fat soy (HF-S), high fat olive (HF-O), high fat fish (HF-F), and a group of standard diet (SD). Blood samples were collected after 8 weeks and after they were fasted for 24 h. Body weight, food intake, plasma glucose, insulin, DAG and insulin resistance (HOMA-IR) were measured. Results: Plasma insulin levels at fed and fasted status, were significantly higher in rats on HF-B compared to those on SD, HF-F and HF-O diets (P<0.05). Insulin concentration in rats on HF-S was also higher than those on SD, HF-F and HF-O diets (P<0.05), in the feeding status. Insulin resistance was significantly higher in rats on HF-B, compared to those on SD, HF-F and HF-O (P<0.05). Rats that were fed with HF-B diet had lower fasting plasma DAG levels than the SD, HF-F and HF-O groups (P<0.05); furthermore, the HF-F group had significantly higher DAG level than the HF-S groups (P<0.05). Conclusions: Fish and olive oils may hence contribute to lower insulin level and HOMA-IR by increasing DAG concentration and may have more health benefits than other fat sources in diets