Background: Poor sleep quality is increasingly recognized as a risk factor for poor health outcomes such as obesity, diabetes and cardiovascular diseases. This study aimed to investigate the association between sleep quality, obesity and glycemic and lipid profiles in Iranian adults in 2020.Methods: 353 adults aged 18-60 years from community centers in Tehran municipality took apart in this cross-sectional study by convenience sampling. Information on anthropometric measurements, physical activity and dietary intake were collected. Sleep quality was assessed through Pittsburgh Sleep Quality Index. Body composition was measured through BIA method. Auto analyzer was used to measure fasting blood sugar (FBS)and lipid profile and ELISA method was used to measure Insulin.Results: The mean age was 42.92±11.34 and 39.16±14.18 for women and men, respectively. Each one score increase in total sleep quality, was related to 0.1 cm increase in waist circumference and 0.3 % increase in body fat percent (P <0.05). BMI had a positive correlation with subscales of “sleep disturbances” and “use of sleep medication” (P <0.001). Physical activity had a significant negative correlation with subscales of “subjective sleep quality” and “sleep latency”. FBS and triglyceride had positive correlation with “sleep latency” and “Subjective sleep quality”, respectively (P <0.05).Conclusion: Some determinants of sleep quality are associated with obesity, disorders of glucose and triglyceride metabolism and low level of physical activity.Keywords: Sleep quality; PSQI questionnaire; Body fat mass; Fasting Blood Sugar; Lipid profil
