\u27Picking and Choosing\u27: Marianne Moore\u27s Strategic Revision of the Romantic Sublime

While many Modernist writers made conscious attempts to position themselves against an existing Romantic literary tradition, careful examinations reveal important overlaps and connections in theme, imagery and purpose. While Marianne Moore\u27s work is perhaps farther away from a Romantic aesthetic than that of many of her contemporaries, a close examination of the body of her work reveals an engagement with many themes, motifs, and ideas that can be traced to her Romantic predecessors, a relationship that might best be described as \u27picking and choosing,\u27 to use her words. Many of her poems involve an appropriation and interrogation of the sublime, an aesthetic discourse that permeated Romantic poetry, and this engagement can be traced through three thematic areas: nature, gender and prophecy. However, in contrast to her Romantic predecessors, Moore\u27s treatment of the sublime is marked by a continual undercurrent of skepticism, particularly regarding the ability of the human mind to know for certain what lies beyond it. She repeatedly characterizes the transcendent impulse as an illusion, as in \u27An Octopus,\u27 when her speaker, who attempts to interact with the sublime landscape of Mt. Rainier, insists, \u27completing a circle, / you have been deceived into thinking that you have pro-- / gressed\u27 (BMM 83-84:23-24). In addition, her poetry undermines established ideological boundaries that have been inscribed in aesthetic discourse since antiquity, particularly regarding the distinction between the beautiful and the sublime, a separation that Moore understood as inextricably linked to gender difference, power, and domination. Taking the notion of the sublime to its logical conclusion in prophecy, the act of uttering the unknowable, her work challenges the idea of the poet as single, authoritative intermediary between the divine and the community of readers. In all of these thematic areas, Moore\u27s relationship to the authority implicit in the discourse of the sublime is fraught. The very notion of having access to an understanding outside the realm of the human brings forth a host of complications for a poet such as Moore, whose reluctance to state a fixed truth without simultaneously undermining it has been the subject of much critical attention

An Exploration of Costume Design For David Emerson Toney\u27s Frankenstein: Dawn of a Monster

This thesis details the Costume Design process for David Emerson Toney’s Frankenstein: Dawn of a Monster at Virginia Commonwealth University. Toney’s original adaptation interprets Mary Shelley’s genre-defying novel as biography, directly influenced by the tragic events of her young life. Costumes differentiate the two narratives, with Mary Shelly in gray scale, regency-inspired modern dress and the novel in period and color. This follows the design process from concept to production to execution

Professional Learning Communities in the Expanded Learning Field

This white paper uses twelve evaluation reports of the Professional Learning Community (PLC) initiatives, as well as interviews with PLC participants and facilitators, to better understand how the PLC model is used in the Expanded Learning field, to demonstrate the benefits to participating staff and expanded learning programs, and to share best practices for youth-serving organizations interested in using PLCs

The 1913 Campaign for Child Labor in Florida

So minutely prepared and well conducted was the campaign for a child labor law for Florida in 1913 that the advocates were surprised when the proposed bill was challenged by a solitary newspaper, The Florida Times Union. According to an official of the National Child Labor Committee, this strong objection on the part of the Jacksonville, Florida newspaper would have wrecked the legislation had it not been for the astute thinking on the part of the authors of the bill when the opposition first appeared

The clinical utility of gene testing for Alzheimer's disease

Alzheimer's disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) ε4 is a susceptibility gene for late-onset AD. The genes for phosphatidylinositol-binding clathrin assembly protein, clusterin and complement receptor 1 have recently been described by genome-wide association studies as potential risk factors for late-onset AD. Also, a genome association study using single neucleotide polymorphisms has identified an association of neuronal sortilin related receptor and late-onset AD. Gene testing, and also predictive gene testing, may be of benefit in suspected familial early-onset AD however it adds little to the diagnosis of late-onset AD and does not alter the treatment. We do not recommend APOE ε4 genotyping

Recommendation on how avoid Interference Issues in companion and organized avalanche rescue

Electronic avalanche rescue devices such as 457kHz transceivers and Recco are today the primary search tools in companion and organized rescue. The requirement for a long receive range in order to shorten rescue time asks for highly sensitive receivers. Such highly sensitive receivers are vulnerable to be influenced by interference from other electronic devices, but as well metal parts and passive electronics may detune the antennas or act as a unwanted reflector in the case of a Recco search. The percentage of users who carry a wide range of electronic devices such as mobile phones, helmet cameras, music players, heart rate monitors etc in the outdoors has considerably increased over time and therefore the negative influence on an efficient search effort has in several cases lead to loss of valuable rescue time and greatly disturbed the rescuers on the accident site. The study includes a detailed analysis on the mechanisms of interference, a matrix of influence and potential consequences as well as a new, user group specific recommendation on how to avoid interference issues in companion and organized rescue

A qualitative interview study applying the COM-B model to explore how hospital-based trainers implement antimicrobial stewardship education and training in UK hospital-based care

BACKGROUND: Antimicrobial resistance (AMR) is a major global health threat caused by the inappropriate use of antimicrobials in healthcare and other settings. Antimicrobial stewardship (AMS) is a broad multi-component health services intervention that promotes and monitors the judicious use of antimicrobials to preserve their future effectiveness. A main component of AMS is education and training (E&T). However, there are often discrepancies in how such interventions are implemented and delivered in hospital-based care. The aim of this study was to explore the factors influencing the implementation of AMS E&T in UK hospitals. METHODS: Semi-structured interviews were carried out with AMS E&T trainers in UK hospitals. The interview schedule was developed using the Capability, Opportunity, Motivation = Behaviour (COM-B) model. Participants were identified via professional networks and social media. Interviews were analysed using inductive thematic analysis, followed by deductive analysis using the COM-B model as a framework. RESULTS: A total of 34 participants (26 antimicrobial pharmacists, 3 nurses, 1 advanced clinical practitioner, 2 infectious disease consultants, 1 microbiologist and 1 clinical scientist). responsible for designing, implementing and evaluating AMS E&T in UK hospitals (five from Northern Ireland, four from Wales, two from Scotland and 23 from England) took part in virtual interviews. Key themes were: (1) The organisational context, including system-level barriers to AMS included competing organisational targets (Reflective motivation and physical opportunity) and the impact of the COVID-19 pandemic on activity (Physical opportunity); (2) Healthcare professionals' roles and the wider multi-disciplinary team, such that AMS roles were defined and addressed poorly in E&T (Social opportunity); and (3) The individual perception of the need for AMS E&T in hospital-based care, manifest in a perceived lack of conviction of the wider threat of AMR and the resulting need for AMS E&T (Reflective motivation). CONCLUSION: This study has identified factors influencing implementation of AMS E&T in UK hospitals and further identified where implemented, AMS E&T did not address real-world challenges. Current AMS E&T needs to be optimised to elicit practice change, with recommendations including training and engaging the wider work-force and drawing upon theoretically-informed intervention development frameworks to inform AMS E&T to better target AMS behaviour change

Protection of White Leghorn chickens by recombinant fowlpox vector vaccine with an updated H5 insert against Mexican H5N2 avian influenza viruses

Despite decades of vaccination, surveillance, and biosecurity measures, H5N2 low pathogenicity avian influenza (LPAI) virus infections continue in Mexico and neighboring countries. One explanation for tenacity of H5N2 LPAI in Mexico is the antigenic divergence of circulating field viruses compared to licensed vaccines due to antigenic drift. Our phylogenetic analysis indicates that the H5N2 LPAI viruses circulating in Mexico and neighboring countries since 1994 have undergone antigenic drift away from vaccine seed strains. Here we evaluated the efficacy of a new recombinant fowlpox virus vector containing an updated H5 insert (rFPV-H5/2016), more relevant to the current strains circulating in Mexico. We tested the vaccine efficacy against a closely related subcluster 4 Mexican H5N2 LPAI (2010 H5/LP) virus and the historic H5N2 HPAI (1995 H5/HP) virus in White Leghorn chickens. The rFPV-H5/2016 vaccine provided hemagglutinin inhibition (HI) titers pre-challenge against viral antigens from both challenge viruses in almost 100% of the immunized birds, with no differences in number of birds seroconverting or HI titers among all tested doses (1.5, 2.0, and 3.1 log10 mean tissue culture infectious doses/bird). The vaccine conferred 100% clinical protection and a significant decrease in oral and cloacal virus shedding from 1995 H5/HP virus challenged birds when compared to the sham controls at all tested doses. Virus shedding titers from vaccinated 2010 H5/LP virus challenged birds significantly decreased compared to sham birds especially at earlier time points. Our results confirm the efficacy of the new rFPV-H5/2016 against antigenic drift of LPAI virus in Mexico and suggest that this vaccine would be a good candidate, likely as a primer in a prime-boostinfo:eu-repo/semantics/publishedVersio