Concomitant Heart Surgery with Pulmonary Hamartoma Resection: A Case Report

Concomitant lesions of the heart and lung are rare, but when present, they pose a therapeutic challenge to surgeons. A combined procedure clears the need for a second major procedure, improving outcomes and providing economic benefits. However, cardiopulmonary bypass may adversely affect the natural history of pulmonary masses when malignancy is suspected. To avoid these suspects, off-pump techniques may be preferred in suitable patients. This article presents a case of simultaneous off-pump coronary artery bypass grafting and pulmonary hamartoma resection in a 53-year-old man who detected a lung mass during preoperative preparation

Hyperglycemia risk factors in leukemia: Case report

Asparaginaz lösemi tedavisinde kullanılan bir enzim olup, antilösemik etkisini dolaşımdaki asparajini azaltarak yapar. En önemli yan etkileri, anafilaksi, pankreatit, diyabet, koagülasyon bozuklukları ve trombozdur. Hiperglisemi L-asparaginazın (L-ASP) iyi bilinen nadir bir yan etkisidir. Çeşitli çalışmalarda insidansın, sadece L-ASP alanlarda %1-14, prednizon ile birlikte L-ASP alanlarda %2-11 ve sadece prednizon alanlarda %0.2 olduğu gösterilmiştir. Ayrıca yaş, obezite ve Down sendromu hiperglisemi riskini artıran faktörlerdendir. Biz burada tedavisi sırasında hiperglisemi gelişen bir vakayı sunarak, lösemide hiperglisemi risk faktörlerini gözden geçirdik.Asparaginase is an enzyme used in the treatment of leukemia. Its antileucemic effect is believed to result from the depletion of circulating asparagine. Major side effects are anaphylaxis, pancreatitis, diabetes, coagulation abnormalities, and thrombosis. Hyperglycemia is a well known but a rare side effect of L-asparaginase (L-ASP). The reported incidences vary widely from 1% to 14% in recipients of L-ASP alone, 2 to 11% in recipients of both L-ASP and prednisone, and only about 0.2% in those receiving prednisone alone. Age, obesity and Down syndrome were contributing factors to the increased risk of hyperglycemia. We evaluate hyperglycemia risk factors in leukemia by presenting a case who develops hyperglycemia during the treatment

Primary bone hemangioma

[No abstract available

Prevention of Retrosternal Pericardial Adhesions After Cardiac Surgery With Mitomycin C

Tanyeli, Omer/0000-0001-6275-7744WOS: 000334820200012PubMed: 24252449Background Cross Mark Retrosternal pericardial adhesions may cause significant injuries to the heart and great vessels in cases that require reoperation. Fibroblast proliferation is one of the mechanisms for adhesion formation. Inhibition of fibroblast proliferation is important in reduction of retrosternal adhesions. Mitomycin C (MMC) is able to reduce fibroblast proliferation. We aimed to determine the effect of MMC on prevention of retrosternal pericardial adhesions after primary cardiac operations. Methods Thirty Sprague-Dawley female rats were used in the study. The rats were divided into two groups. First group was control (n = 10) and second group was MMC study group (n = 20). Xiphoid cartilage resection and retrosternal abrasion via subxiphoidal incision was performed. In the study group, MMC (1 mg/kg) was topically applied to the retrosternal space. After 15 days, rats were taken into reoperation and adhesion was graded. Tissue and blood samples were taken before termination procedure. Standard staining procedures and fibroblast growth factor receptor 3 antibody staining, were applied immunohistochemically to tissue samples. Results The average adhesion scores of the control (n = 10) and study (n = 20) (MMC; 1 mg/kg) groups were 2.50 +/- 1.27 and 0.70 +/- 0.86, respectively. The adhesion score of the study group was lower than the control group (p 0.05). Conclusion MMC was found to be effective in the prevention of retrosternal pericardial adhesions without any delay in normal tissue regeneration.Scientific Research Projects Coordinator's Office of our university [1007/0710]This study was funded by the Scientific Research Projects Coordinator's Office of our university (Project No: 1007/0710)

Prevalence of GB virus C / hepatitis G virus infection in pediatric patients receiving multiple transfusions in Southern Turkey

The aim of this study was to determine the prevalence of GB virus C (GBV-C) infection in pediatric patients receiving multiple blood transfusions in Turkey where HBV and HCV infections are common. Sera of a total of 148 children, of whom 85 had cancer and 63 hemoglobinopathies, were tested for GBV-C RNA and HCV RNA by RT-PCR and for antibodies to HBV and HCV. Demographic and clinical information as well as laboratory results were recorded for the patients (81 boys, 67 girls, aged 1-19 years). HBsAg positivity was found in 23 (15.5%) patients, HBV DNA positivity in 12 (8.1%), HCV RNA positivity in 9 (6.7%), and GBV-C RNA positivity in 4 (2.7%). There was no significant difference in the GBV-C RNA positivity between patients with cancer (3.2%) and patients with hemoglobinopathies (2.4%) (p > 0.05). GBV-C RNA was found in 4 (3.1%) out of 127 patients who had received transfusions, but it was not found in any of 21 patients who had not received transfusions. However, there was no relationship between GBV-C RNA positivity and the number of transfusions. Two of the patients with GBV-C RNA had high levels of ALT (ALT > 40 IU). In these two patients, neither HBV DNA nor HCV RNA were detected by PCR, and serological tests were also negative for these agents. We concluded that pediatric patients who had multiple transfusions in Turkey are at risk of being infected with GBV-C, in addition to HBV and HCV. Investigation of GBV-C RNA in patients with high ALT levels in the absence of other viral markers may be useful.The aim of this study was to determine the prevalence of GB virus C (GBV-C) infection in pediatric patients receiving multiple blood transfusions in Turkey where HBV and HCV infections are common. Sera of a total of 148 children, of whom 85 had cancer and 63 hemoglobinopathies, were tested for GBV-C RNA and HCV RNA by RT-PCR and for antibodies to HBV and HCV. Demographic and clinical information as well as laboratory results were recorded for the patients (81 boys, 67 girls, aged 1-19 years). HBsAg positivity was found in 23 (15.5%) patients, HBV DNA positivity in 12 (8.1%), HCV RNA positivity in 9 (6.7%), and GBV-C RNA positivity in 4 (2.7%). There was no significant difference in the GBV-C RNA positivity between patients with cancer (3.2%) and patients with hemoglobinopathies (2.4%) (p > 0.05). GBV-C RNA was found in 4 (3.1%) out of 127 patients who had received transfusions, but it was not found in any of 21 patients who had not received transfusions. However, there was no relationship between GBV-C RNA positivity and the number of transfusions. Two of the patients with GBV-C RNA had high levels of ALT (ALT > 40 IU). In these two patients, neither HBV DNA nor HCV RNA were detected by PCR, and serological tests were also negative for these agents. We concluded that pediatric patients who had multiple transfusions in Turkey are at risk of being infected with GBV-C, in addition to HBV and HCV. Investigation of GBV-C RNA in patients with high ALT levels in the absence of other viral markers may be useful

Serum Copper, Zinc and Magnesium Levels in Children with Various Malignant Disorders

Amaç: Bakır, çinko, magnezyum dahil olmak üzere birçok iz elementlerin küçük miktarları dahi birçok biyolojik organların temel bileşenleri olarak rol oynamaktadır. Bu elementlerin serum konsantrasyonları bazı malign durumlarda değişiklik gösterirler. Bu çalışmanın amacı, çeşitli malign hastalığı olan çocukların serumlarındaki bakır, çinko ve magnezyum düzeylerini araştırmaktır. Materyal ve Metod: Çeşitli malign hastalıklara sahip 82 çocuğun ve kontrol grubunu oluşturan yaş olarak denk 21 sağlıklı çocuğun bakır, çinko ve magnezyum düzeyleri atomik absorpsiyon spektrofotometre kullanılarak ölçüldü. Bulgular: Akut lenfoblastik lösemili hastalarda ki (ALL) serum Cu, Zn ve Mg konsantrasyonları (pPurpose: The minute amounts of several trace elements including copper, zinc and magnesium play some roles as essential constituents of various biological organs. The serum concentrations these elements are modified in some malignancies. The aim of this study is to investigate the copper, zinc and magnesium levels in the serum of children with various malignant disorders. Material and Methods: The serum levels of copper, zinc and magnesium were measured in 82 children with various malignant disorders and in 21 age-matched healty controls using an atomic absorbtion spectrophotometer. Results: The serum Cu, Zn and Mg concentrations were significantly higher than matched control values among patients with acute lymphoblastic leukemia (ALL) (

A case of rhabdomyosarcoma with widespread metastasis

Dokuz yaşında erkek hasta, bir ay içinde beş kilogram zayıflama ve kuru öksürük şikayetleri ile başvurdu. Olgunun fizik incelemesinde, akciğerde solunum sesleri azalmış, servikal, sol aksiller, sağ inguinal bölgede çok sayıda ve çeşitli boyutlarda lenfadenopati ve peniste kitle saptandı. Yapılan tetkiklerde mediastende, akciğerde (parankiminde ve plevrada), batında (yaygın olarak ve perineye kadar uzanan) değişik boyutlarda, en büyüklerinin çapı 5 cm'e ulaşan lobule konturlu düşük dansiteli yumuşak doku kitleleri izlenmekteydi. Olgudan alman biyopsi sonucunda embrional rhabdomyosarkom tanısı kondu. Tedavi olarak Vinkristin, İfosfamid ve Etoposid uygulandı. Olgu ikinci ayında yapılan değerlendirmede remisyona girdiği tespit edildi. Halen 14. ayda ve tedavisi devam etmektedir.A 9 year-old-boy was admitted to hospital with complaints of cough and weight loss. Physical examination revealed findings of decreased respiration and multiple lymphadenopathy in cervical, left axiller and right inguinal regions. He had a tumor mass on his penis. Computed tomography showed that in the lung (paranchima and pleura), mediastinal and abdominal soft tissue masses were present having diameters between 1 and 5 cm. Biopsy specimen revealed embryonal rhabdomyosarcoma. He was administered Vincristine, Ifosphamide and Etoposide treatment. He is currently alive and healthy at his 14th month of follow-up

G-CSF-mobilized haploidentical peripheral blood stem cell transplantation in children with poor prognostic nonmalignant disorders

Haploidentical hematopoletic stem cell transplantation (HSCT) is currently one of the alternative curative treatment options for some nonmalignant but also for malignant diseases. However, concerns regarding its safety cause delays in time and a successful outcome. Between 2000 and 2005, twenty-one children with poor prognostic nonmalignant disorders, 13 boys and 8 girls, with a median age of 12 months, underwent 28 haploidentical peripheral HSCT. Immunomagnetic bead depletion device (CliniMACS) was used for indirect T-cell depletion. Indications for transplant were severe combined immunodeficiency (n = 16), osteopetrosis (n = 2), MDS (n = 1), amegakaryocytic thrombocytopenia (n = 1), and aplastic anemia (n = 1). Five patients (24%) had lung infection at the time of transplantation. The patients received a median of 25.67 x 10(6) G-CSF-mobilized peripheral CD34(+) progenitor cells and a median of 4.19 x 10(4) T-lymphocytes per kilogram of body weight with a T-cell depletion rate of median 4.59 logs. The rate of total engraftment was 66.6%. Median times for leukocyte and platelet engraftment were 14 and 16 days, respectively. The 6-year projected survival was 32% for all patients and 29.76% for patients with severe combined immunodeficiency (SCID). The rates of transplant-related mortality, graft failure, and severe GvHD were 14.2, 33.4%, and 8.3%, respectively. Infection was the main cause of death. The poor outcome may be explained with the poor prognostic factors of our patients such as the type of SCID in most cases (T-B-SCID), the median age over 6 months and the presence of lung infection in some children at the time of transplantation

Prevention of Retrosternal Pericardial Adhesions After Cardiac Surgery With Mitomycin C

Tanyeli, Omer/0000-0001-6275-7744WOS: 000334820200012PubMed: 24252449Background Cross Mark Retrosternal pericardial adhesions may cause significant injuries to the heart and great vessels in cases that require reoperation. Fibroblast proliferation is one of the mechanisms for adhesion formation. Inhibition of fibroblast proliferation is important in reduction of retrosternal adhesions. Mitomycin C (MMC) is able to reduce fibroblast proliferation. We aimed to determine the effect of MMC on prevention of retrosternal pericardial adhesions after primary cardiac operations. Methods Thirty Sprague-Dawley female rats were used in the study. The rats were divided into two groups. First group was control (n = 10) and second group was MMC study group (n = 20). Xiphoid cartilage resection and retrosternal abrasion via subxiphoidal incision was performed. In the study group, MMC (1 mg/kg) was topically applied to the retrosternal space. After 15 days, rats were taken into reoperation and adhesion was graded. Tissue and blood samples were taken before termination procedure. Standard staining procedures and fibroblast growth factor receptor 3 antibody staining, were applied immunohistochemically to tissue samples. Results The average adhesion scores of the control (n = 10) and study (n = 20) (MMC; 1 mg/kg) groups were 2.50 +/- 1.27 and 0.70 +/- 0.86, respectively. The adhesion score of the study group was lower than the control group (p 0.05). Conclusion MMC was found to be effective in the prevention of retrosternal pericardial adhesions without any delay in normal tissue regeneration.Scientific Research Projects Coordinator's Office of our university [1007/0710]This study was funded by the Scientific Research Projects Coordinator's Office of our university (Project No: 1007/0710)

Risk factors for paediatric patients with relapsed/refractory NHL who underwent hematopoietic stem cell transplantation: Results of the Turkish paediatric bone marrow transplantation study group

WOS: 000384818800392