Does dual-energy abdominal computed tomography increase the radiation dose to patients : a prospective observational study

Purpose: The aim of our study was to compare single-energy (SECT) and dual-energy (DECT) abdominal computed tomography (CT) examinations in matched patient cohorts regarding the differences in effective radiation dose (ERD) and image quality performed in a third-generation dual-source computed tomography (DSCT) scanner. Material and methods: Our study included 100 patients, who were divided randomly into 2 groups. The patients included in Group A were scanned by SECT, and Group B members were scanned by DECT. Volume CT dose index (CTDIvol), dose length product (DLP), and ERD for venous phase acquisition were recorded in each patient and were normalised for 40 cm. Analyses were performed by using statistical software (SPSS version 20.0 for windows), and Bonferroni correction for multiple comparisons was applied for p-values and confidence intervals. Results: Average ERD based on DLP values normalised for 40 cm acquisition were obtained for both Group A and Group B. The mean ERD for Group A was 11.89 mSv, and for group B it was 6.87 mSv. There was a significant difference in these values between Group A and Group B as shown by a p-value of < 0.001. On subjective and objective analysis, there was no statistically significant difference in image quality between the 2 groups. Conclusions: The protocols in third-generation DSCT using dual-energy mode resulted in significant reductions in the effective radiation dose (by approximately 58%) compared to SECT in routine abdominal examination in matched cohorts. Therefore, the quantitative imaging potential of DECT can be utilised in needed patients with decreased radiation dose in third-generation DSCT

Gender Mainstreaming and Impact of Self-Help Groups: A Study on Social Entrepreneurship through Fish Aggregating Devices in Mannancheri of Alappuzha, Kerala

A research study for assessing the impact of fisher folk Self Help Groups in gender mainstreaming was undertaken on social entrepreneurship venture on fish aggregating devices at Mannancheri gramapanchayath, located at Alappuzha district of Kerala. The analysis included specific aspects such as performance assessment of the SHGs, gender analysis and empowerment analysis which were carried out based on socio-economic surveys and personal interviews using pre-tested and structured data gathering protocols with standardized scales and indices involving the members of the SHGs. The male and female counterparts of the families were separately interviewed to assess the gender mainstreaming aspects in terms of equity and equality to access to resources, participation profile, decision making aspects, gender need analysis etc. Though majority of activities are male dominated, the female counterparts of the households also have definite role in decision making, purchase of accessories etc. A success case study was elucidated and documented as a documentary which can be used as a case model for promoting group action for mobilizing SHGs on a sustainable basis

Ligand-based virtual screening interface between PyMOL and LiSiCA

Ligand-based virtual screening of large small-molecule databases is an important step in the early stages of drug development. It is based on the similarity principle and is used to reduce the chemical space of large databases to a manageable size where chosen ligands can be experimentally tested. Ligand-based virtual screening can also be used to identify bioactive molecules with different basic scaffolds compared to already known bioactive molecules, thus having the potential to increase the structural variability of compounds. Here, we present an interface between the popular molecular graphics system PyMOL and the ligand-based virtual screening software LiSiCA available at http://insilab.org/lisica-plugin and demonstrate how this interface can be used in the early stages of drug discovery process