A triclinic polymorph of 3-nitro­anilinium chloride

The asymmetric unit of the title compound, C6H7N2O2 +·Cl−, contains two independent ion pairs. A monoclinic form of the title compound with only one ion pair in the asymmetric unit has been reported previously [Ploug-Sørensen & Andersen (1986). Acta Cryst. C42, 1813–1815]. In the crystal of the title compound, the components are linked into layers parallel to (001) by inter­molecular N—H⋯Cl hydrogen bonds, with alternating hydro­philic and hydro­phobic regions

Creatininium hydrogen maleate

In the title compound, C4H8N3O+·C4H3O4 −, the cations and anions are linked through N—H⋯O hydrogen bonds making a ionic pair with an R 2 2(8) ring motif. These ionic pairs are further connected through another N—H⋯O hydrogen bond, leading to an R 6 6(16) ring motif around the inversion centres of the unit cell. These approximately planar aggregates are further connected through weak van der Waals inter­actions in the unit cell. The anions have a characteristic intra­molecular O—H⋯O hydrogen bond with a self-associated ring S(7) motif

The combinational effect of cardiac and biochemical markers in diabetic patients with cardiovascular disease

Background: Clinicopathological correlations, as well as several angiographic studies, suggest that diabetic patients have more extensive atherosclerotic disease, affecting the coronary arteries in particular. We sought to examine the combinational effect of cardiac and biochemical markers in diabetic patients with cardiovascular disease.\ud Method: The study population constituted 50 healthy subjects, 50 cardiovascular subjects with diabetes and 50 cardiovascular subjects without diabetes. The population was subjected to biochemical and cardiac marker analysis and the results were verified.\ud Results and discussion: Studies suggest that glycated hemoglobin values in the abnormal range can identify persons at increased risk for coronary heart disease, stroke, and death before the diagnosis of diabetes, indicating that glycated hemoglobin is a useful marker of cardiovascular risk and death from any cause.\u

1,5-Dimethyl-3-oxo-2-phenyl-2,3-di­hy­dro-1H-pyrazol-4-aminium 2-hydroxy­benzoate

In the title salt, C11H14N3O+·C7H5O3 −, the phenyl ring of the cation is oriented at an angle of 67.0 (1)° with respect to the five-membered pyrazolone ring. The carboxyl­ate plane of the anion is twisted out from the plane of the aromatic ring at an angle of 13.7 (3)°. In the crystal, the cations form hydrogen-bonded dimers with an R 2 2(10) ring motif. The salicylate anion has an intra­molecular O—H⋯O hydrogen bond

The role of statin drugs in combating cardiovascular diseases –A review

Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease. Increased cholesterol levels have been associated with cardiovascular diseases (CVD), and statins are therefore used in the prevention of these diseases. Studies have found that the ability of a particular statin to lower or reduce LDL is proportional to the amount it can increase HDL levels. This review article will focus on the effective role of statin in cardiovascular disease and comparison was made between various classes of statin drugs

Nicotinamide–2,2,2-trifluoro­ethanol (2/1)

The nicotinamide (NA) mol­ecules of the title compound, 2C6H6N2O·C2H3F3O, form centrosymmetric R 2 2(8) hydrogen-bonded dimers via N—H⋯O contacts. The asymmetric unit contains two mol­ecules of NA and one trifluoroethanol molecule disordered over two sites of equal occupancy. The packing consists of alternating layers of nicotinamide dimers and disordered 2,2,2-trifluoro­ethanol mol­ecules stacking in the c-axis direction. Intra­molecular C—H⋯O and inter­molecular N—H⋯N, O—H⋯N, C—H⋯N, C—H⋯O and C—H⋯F inter­actions are present

(E)-3-Phenyl-3-(3-phenyl-1H-1-pyrazol­yl)-2-propenal

In the title compound C18H14N2O, the pendant rings make dihedral angles of 66.1 (1)° and 13.9 (1) with the central ring. In the crystal, two mol­ecules form a cyclic centrosymmetric R 2 2(22) dimer through pairs of C—H⋯O bonds. These dimers are further connected into zigzag chains extending along the b axis through C—H⋯π and C—H⋯O inter­actions

Ethyl (1R,1′S,2′S,7a’R)-2-oxo-1′-[(3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetra­methyl­tetra­hydro-3aH-bis­[1,3]dioxolo[4,5-b:4′,5′-d]pyran-5-yl]-1′,2′,5′,6′,7′,7a’-hexa­hydro-2H-spiro­[acenaphthyl­ene-1,3′-pyrrolizine]-2′-carboxyl­ate

In the title compound, C32H37NO8, the central pyran ring adopts a twist-boat conformation and the 1,3-dioxoane rings adopt envelope conformations. The acenaphthyl­enone unit and two C atoms of a pyrrolidine ring are disordered over two sets of sites [occupancy ratio 0.669 (7):0.331 (7)]. The major fraction of the disordered pyrrolidine ring exhibits an envelope conformation while the minor component is essentially planar [maximum deviation = 0.037 (12) Å]. The other pyrrolidine ring also adopts an envelope conformation. The dihedral angle between the mean planes of the two wings of the pyrrolidine ring is 30.6 (2)°. Both the major and minor components of the acenaphthyl­enone unit are essentially planar, the maximum deviations being 0.025 (10) and 0.047 (19) Å, respectively; the dihedral angle between the mean planes of the two components is 1.72 (3)°. The crystal packing features C—H⋯O inter­actions

2-Amino-6-(2,4-dichloro­phen­yl)-4-oxo-3,5-diphenyl­cyclo­hex-2-enecarbonitrile

In the title compound, C25H18Cl2N2O, the cyclo­hexene ring has a sofa conformation. All the substituents in the cyclo­hexene ring, except the cyano group (which is axial) occupy equatorial positions. The crystal structure is stabilized through N—H⋯O hydrogen bonds, forming a chain extending along the b axis and through C—H⋯N and C—H⋯Cl inter­actions. It is remarkable that only one of the amino H atoms is involved in hydrogen bonding

Designing a new vanillin Schiff base (Z)-4-((2-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one: Synthesis, characterization, crystal structure and biological studies

1110-1116Novel Schiff base containing antipyrine and o-vanillin has been synthesized and characterized by various physicochemical techniques such as FTIR, UV-Vis, CHN, 1Hand 13C NMR spectral studies. The thermal behavior of the title compound has been examined with Thermogravimetric-Differential thermal analysis (TG-DTA). The structural properties have been further examined by single crystal X-ray diffraction studies. The X-ray diffraction data shows that the compound contains four molecules in the asymmetric unit. Antifungal activity of the compound has been carried out for four different fungi Aspergillus niger, Aspergillus flavus, Aspergillus terrus and Fusarium Sp at three different concentrations, whereas the compound shows significant activity against the fungi Aspergillus niger