Epidemiologic Survey of Kawasaki Disease in Jilin from 1999 Through 2008

The epidemiologic pictures of Kawasaki disease (KD) in Jilin Province of China is still not clear. We sent a questionnaire form and diagnostic guidelines for KD to the province's 32 hospitals above the county and city level with pediatric in-patients. All patients with KD diagnosed during January 1999 through December 2008 were recruited in this survey. The incidence of KD was 1.39 to 11.07 (5.26 ± 3.97) per 100,000 children under the age of 5 years between 1999 and 2008. The ratio of male to female was 1.96 to 1. Ages at onset ranged from 58 days to 14 years. Patients under 5 years of age accounted of 88.73%. The disease occurred throughout the year, but it occurred more frequently in May to July and November. The most common cardiac abnormality was coronary artery dilatation (49.5%). Age at onset and hypoalbuminemia (<30 g/l) were selected for multivariate logistic regression equation. In conclusion, incidences of KD increased in Jilin Province. Age and gender distribution shared similarities with previous reports, and the seasonal distribution was different. Age and lower serum albumin were the most important risk factors of coronary arterial lesions (CAL) in KD. In addition, patients treated with steroids also had a possible heightened risk of contracting CAL

Predictors of Paravalvular Regurgitation Following Implantation of the Fully Repositionable and Retrievable Lotus Transcatheter Aortic Valve (From the REPRISE II Trial Extended Cohort)

Paravalvular leak (PVL) following transcatheter aortic valve replacement (TAVR) is associated with worse long-term outcomes. The Lotus Valve incorporates an innovative adaptive seal designed to minimize PVL. This analysis evaluated the incidence and predictors of PVL following implantation of the Lotus transcatheter aortic valve. The REPRISE II study with Extended Cohort enrolled 250 high-surgical risk patients with severe symptomatic aortic stenosis. Aortic regurgitation was assessed by echocardiography pre-procedure, at discharge and 30 days by an independent core lab. Baseline and procedural predictors of mild or greater PVL at 30 days (or at discharge if 30-day data were not available) were determined using a multivariate regression model (N=229). Among 229 patients, 197 (86%) had no/trace PVL, 30 had mild, and 2 had moderate PVL; no patient had severe PVL. Significant predictors of mild/moderate PVL included device:annulus area ratio (odds ratio [OR]: 0.87 (95% CI: 0.83-0.92); P&lt;0.001), LVOT calcium volume (OR:2.85;(1.44-5.63); P=0.003), and annulus area (OR:0.89(0.82-0.96); P=0.002). When the device:annulus area ratio was &lt;1, the rate of mild/moderate PVL was 53.1% (17/32). The rates of mild/moderate PVL with 0-5%, 5-10%, and &gt;10% annular oversizing by area were 17.5% (11/63), 2.9% (2/70), and 3.2% (2/63), respectively. Significant independent predictors of PVL included device:annulus area ratio and LVOT calcium volume. When the prosthetic valve was oversized by ≥5%, the rate of mild or greater PVL was only 3%. In conclusion, the overall rates of PVL with the Lotus Valve are low and predominantly related to device/annulus areas and calcium; these findings have implications for optimal device sizing

Prediction of paravalvular leakage after transcatheter aortic valve implantation

Significant paravalvular leakage (PVL) after transcatheter aortic valve implantation (TAVI) is related to patient mortality. Predicting the development of PVL has focused on computed tomography (CT) derived variables but literature targeting CoreValve devices is limited, controversial, and did not make use of standardized echocardiographic methods. The study included 164 consecutive patients with severe aortic stenosis that underwent TAVI with a Medtronic CoreValve system©, with available pre-TAVI CT and pre-discharge transthoracic echocardiography. The predictive value for significant PVL of the CT-derived Agatston score, aortic annulus size and eccentricity, and “cover index” was assessed, according to both echocardiographic Valve Academic Research Consortium (VARC) criteria and angiographic Sellers criteria. Univariate predictors for more than mild PVL were the maximal diameter of the aortic annulus size (for both angiographic and echocardiographic assessment of PVL), cover index (for echocardiographic assessment of PVL only), and Agatston score (for both angiographic and echocardiographic assessment of PVL). The aortic annulus eccentricity index was not predicting PVL. At multivariate analysis, Agatston score was the only independent predictor for both angiographic and echocardiographic assessment of PVL. Agatston score is the only independent predictor of PVL regardless of the used imaging technique for the definition of PVL

Synthesis and spectral characterization of copper(II), nickel(II), cobalt(II), oxovanadium(IV) and ruthenium(II) complexes of some conjugated 2-hydroxyacetophenones

317-320A few metal complexes of the type ML2nB [where M=Cu(II), Ni(II), Co(II) and VO(II); L=2-hydroxy-ω- (2' -furylacryloyl)-acetophenone(HFA); B=H2O; n=0,2] and Ru(II) complexes of 2-hydroxy-ω-(4-Xcinnamoyl) acetophenones (HXCA) [where X=H, CI, Me or OMe] have been prepared and characterized by elemental analysis, IR; electronic, and ESR spectra and magnetic susceptibility studies. The ligands coordinate through carbonyl and enolic oxygens. From the ESR spectra it is observed that copper(II) and vanadyl(IV) complexes are monomers

Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of quinoline-8- sulphinic acid

400-402Quinoline-8-sulphinic acid (QNSOOH) acts as an ambidentate ligand coordinating through different modes with various transition metal(II) ions. Copper(II) forms a dimer, CU2(QNSOO)2CI2.4H2O,with sulphinato-N, S at pH1 and a monomer, Cu(QNSOO)2.2H2O, with sulphinato-N, O at pH 3. NickeI(II) forms a high spin octahedral sulphinato-N, S complex, while cobaIt(II) forms a low spin octahedral sulphinato-N, S complex. Zinc(II) forms sulphinato-N, O complex and cadmium(II) due to the ‘proximity effect’ forms only sulphinato-O, O complex. All these sulphinato complexes are characterisea with the help of elemental analysis, magnetic moment, conductivity measurement, molecular weight determination, IR and electronic spectra

Synthesis and characterization of copper(II), nickel(II), cobalt(II), zinc(II) and cadmium(II) complexes of 5,6-diphenyl-3-(2 -hydroxyphenyl)-1, 2, 4-triazine

152-153A few complexes of the type ML2.nB, [where M =Cu(II), Ni(U), Co(ll), Zn(II), Cd(II); L =5,6-diphenyl-3-(2'- hydroxyphenyl)-1, 2, 4-triazine (DPTH); B= H2O; n = 0, 2] have been synthesized and characterized on the basis of elemental analysis, magnetic susceptibility, thermal studies and IR and electronic spectra. It is observed from the IR studies that the nitrogen in 2-position of DPTH is coordinated to the metal ion in all the cases

Synthesis, spectral and electrochemical studies of ruthenium(II)/(III) complexes of alicyclic β-ketamines

426-429A series of ruthenium(II)/(III) complexes of alicyclic β-ketamines derived from 2-formylcyclohexanone and 4-X-substituted anilines, HFCA-X (where H is an ionisable enolichydrogen and X = H, Cl, Br, OMe and NO2) , have been prepared and characterized by spectroscopic techniques. The IR spectral data suggest the coordination of enolic oxygen and imino nitrogen to ruthenium. Ruthenium(I I) complexes are diamagnetic (low spin d6, S = 0) and in solutions show intense MLCT transition. Their redox behaviours have been studied by cyclic voltammetry. The solid state low temperature ESR spectra of Ru(III) complexes show a low spin symmetry