PENGARUH PEMBELAJARAN KOLABORATIF BERBASIS LESSON STUDY LEARNING COMMUNITY (LSLC) TERHADAP HASIL BELAJAR SISWA PADA POKOK BAHASAN PELUANG

The purpose of this study was to determine whether or not there was an influence between Lesson Study Learning Community (LSLC) collaborative learning on student learning outcomes on opportunity topics in SMP Negeri 8 Jember.This research is an experimental study, using the form of True Experiment Design with Randomized Pre-test and Post-test Control Group Design research designs. The study population was all eighth grade students. The 3 class samples from 7 classes are homogeneous, the sample is divided into experimental class 1, experimental class 2, and control class. Data collection is done by documentation, tests and observations. Based on the results of F test data analysis on the Post-test value obtained Ftabel <Fhitung is 3.08 <11,673, then H0 is rejected. The results of the Post Hoc test showed that the experimental class 1 had a significant difference compared to the experimental class 2 and the control class. In the experimental class 1 students discussed to solve the problem, the interaction between students in the experimental class 1 happened well compared to the experimental class 2 and the control class, so that collaboration and student learning outcomes increased. Then it can be concluded that collaborative learning based on Lesson Study Learning Community (LSLC) influences student learning outcomes. Student learning outcomes in the experimental class 1 increased by 6.67%, this is higher than the experimental class 2 of 3.19 and the control class of 3.56.   Keywords: Collaborative Learning,  LSLC, Learning Outcome

Transverse Electronic Transport through DNA Nucleotides with Functionalized Graphene Electrodes

Graphene nanogaps and nanopores show potential for the purpose of electrical DNA sequencing, in particular because single-base resolution appears to be readily achievable. Here, we evaluated from first principles the advantages of a nanogap setup with functionalized graphene edges. To this end, we employed density functional theory and the non-equilibrium Green's function method to investigate the transverse conductance properties of the four nucleotides occurring in DNA when located between the opposing functionalized graphene electrodes. In particular, we determined the electrical tunneling current variation as a function of the applied bias and the associated differential conductance at a voltage which appears suitable to distinguish between the four nucleotides. Intriguingly, we observe for one of the nucleotides a negative differential resistance effect.Comment: 19 pages, 7 figure

REMOVAL OF BASIC BLUE 3 AND REACTIVE ORANGE 16 BY ADSORPTION ONTO QUARTENIZED SUGAR CANE BAGASSE

Abstract The effectiveness of using sugar cane bagasse, an agricultural by-product, as a sorbent to remove basic and reactive dyes from aqueous solution was studied. The quartenized sugar cane bagasse (QSB) is capable in removing both Basic Blue 3 (BB3) and Reactive Orange 16 (RO16). The sorption of dye solutions was strongly affected by pH, where the optimum pH is 6-8. The kinetics of the dye sorption processes fitted a pseudo-second order kinetic model. Results indicated that the adsorption isotherms fitted well into both the Langmuir and Freundlich isotherms. The removal of BB3 was favourable at higher temperature, indicating that the sorption process was endothermic. On the other hand, sorption of RO16 on QSB was more favourable at low temperature. Keywords: Sugar cane bagasse; quartenization; sorption; reactive dyes; basic dyes Abstrak Keberkesanan menggunakan sisa tebu, produk sampingan pertanian, sebagai penjerap untuk menyingkirkan pewarna basik dan reaktif daripada larutan telah dikaji. Sisa tebu yang diquarternasi (QSB) adalah berupaya untuk menyingkirkan keduadua pewarna Basik Biru 3 (BB3) dan Reaktif Oren 16 (RO16). Penjerapan pewarna adalah dipengaruhi oleh pH, di mana pH optimum ialah 6-8. Kinetik proses erapan pewarna didapati mengikut model kinetik tertib pseudo-kedua. Keputusan eksperimen menunjukkan bahawa isoterma penjerapan mematuhi kedua-dua isoterma Langmuir dan Freundlich. Penyingkiran BB3 adalah lebih baik pada suhu tinggi, menunjukkan proses erapan adalah endotermik. Manakala erapan RO16 ke atas QSB adalah lebih digemari pada suhu rendah

Don’t make me angry, you wouldn’t like me when I’m angry: volitional choices to act or inhibit are modulated by subliminal perception of emotional faces

Volitional action and self-control—feelings of acting according to one’s own intentions and in being control of one’s own actions—are fundamental aspects of human conscious experience. However, it is unknown whether high-level cognitive control mechanisms are affected by socially salient but nonconscious emotional cues. In this study, we manipulated free choice decisions to act or withhold an action by subliminally presenting emotional faces: In a novel version of the Go/NoGo paradigm, participants made speeded button-press responses to Go targets, withheld responses to NoGo targets, and made spontaneous, free choices to execute or withhold the response for Choice targets. Before each target, we presented emotional faces, backwards masked to render them nonconscious. In Intentional trials, subliminal angry faces made participants more likely to voluntarily withhold the action, whereas fearful and happy faces had no effects. In a second experiment, the faces were made supraliminal, which eliminated the effects of angry faces on volitional choices. A third experiment measured neural correlates of the effects of subliminal angry faces on intentional choice using EEG. After replicating the behavioural results found in Experiment 1, we identified a frontal-midline theta component—associated with cognitive control processes—which is present for volitional decisions, and is modulated by subliminal angry faces. This suggests a mechanism whereby subliminally presented “threat” stimuli affect conscious control processes. In summary, nonconscious perception of angry faces increases choices to inhibit, and subliminal influences on volitional action are deep seated and ecologically embedded

Crowdsourced mapping of unexplored target space of kinase inhibitors

Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexplored compound-kinase interactions for novel and potent activities. Here, we carry out a crowdsourced benchmarking of predictive algorithms for kinase inhibitor potencies across multiple kinase families tested on unpublished bioactivity data. We find the top-performing predictions are based on various models, including kernel learning, gradient boosting and deep learning, and their ensemble leads to a predictive accuracy exceeding that of single-dose kinase activity assays. We design experiments based on the model predictions and identify unexpected activities even for under-studied kinases, thereby accelerating experimental mapping efforts. The open-source prediction algorithms together with the bioactivities between 95 compounds and 295 kinases provide a resource for benchmarking prediction algorithms and for extending the druggable kinome. The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts